Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may b
Disclosed are hemodialysis and similar dialysis systems including fluid flow circuits. Hemodialysis systems may include a blood flow path, and a dialysate flow path including balancing, mixing, and/or directing circuits. Preparation of dialysate may be decoupled from patient dialysis. Circuits may be defined within one or more cassettes. The fluid circuit and/or the various fluid flow paths may be isolated from electrical components. Fluid circuits and electrical components may be contained in a housing comprising a first section separated from a second section by a thermally insulating barrier. The first section may house a heater and heat-sterilizable components including liquid flowpaths, pumps or valves, while the second section houses electronic components for controlling the hemodialysis system. The insulating barrier may be configured to inhibit the second section from being exposed to sterilizing temperatures produced in the first section.
대표청구항▼
1. A hemodialysis system comprising: a housing comprising a first section separated from a second section by a thermally insulating barrier;the first section housing a heater and heat-sterilizable components including liquid flowpaths, pumps or valves;the second section housing electronic components
1. A hemodialysis system comprising: a housing comprising a first section separated from a second section by a thermally insulating barrier;the first section housing a heater and heat-sterilizable components including liquid flowpaths, pumps or valves;the second section housing electronic components for controlling the hemodialysis system, whereinthe insulating barrier is configured to inhibit the second section from being exposed to sterilizing temperatures produced in the first section. 2. The hemodialysis system of claim 1, wherein the first section is closed to the external environment when the liquid flowpaths, pumps or valves are undergoing heat sterilization. 3. The hemodialysis system of claim 1, wherein the second section is open to the external environment when the liquid flowpaths, pumps or valves are undergoing heat sterilization. 4. The hemodialysis system of claim 1, wherein the second section includes a manifold, and the first section includes a plurality of control fluid lines for controlling a plurality of pumps or valves in the first section. 5. The hemodialysis system of claim 4, wherein the manifold is a pneumatic manifold, and the control fluid lines are configured to carry air under positive or negative pressure. 6. The hemodialysis system of claim 5, wherein the control fluid lines are connected on one end to the pumps or valves, and are connected on an opposing end to a tube-support housing, the tube support housing configured to reversibly connect the plurality of control fluid lines to a mating receptacle fluidically connected across the insulating barrier with the pneumatic manifold. 7. The hemodialysis system of claim 1, wherein the heater is configured to heat liquid in the liquid flowpaths, pumps or valves to a temperature of at least about 80 degrees C., while the temperature in the first section is prevented from exceeding about 60 degrees C. 8. The hemodialysis system of claim 3, wherein the second section includes a fan or grid to circulate air between the second section and the external environment. 9. The hemodialysis system of claim 1, wherein the second section includes an electronic controller, a power supply, or a pneumatic manifold. 10. The hemodialysis system of claim 1, wherein the first section includes a liquid pumping cassette, one or more temperature sensors, one or more conductivity sensors, or a blood leak sensor. 11. The hemodialysis system of claim 10, wherein the first section includes the liquid pumping cassette, and wherein the liquid pumping cassette comprises a plurality of membrane-based pumps, membrane-based valves, liquid flow paths, liquid inlets, liquid outlets, and control fluid ports. 12. The hemodialysis system of claim 11, further comprising a sensor manifold, the sensor manifold comprising a plurality of liquid conduits, each liquid conduit including a temperature or conductivity sensor, wherein the liquid conduits are configured to fluidically connect with a plurality of liquid flow paths in the pumping cassette. 13. The hemodialysis system of claim 12, wherein one or more liquid conduits of the sensor manifold comprises an air trap. 14. The hemodialysis system of claim 1, wherein the insulating barrier comprises an insulating wall comprising insulation. 15. The hemodialysis system of claim 14, wherein the insulation comprises molded foam insulation, spray insulation, or an insulation cut from sheets. 16. The hemodialysis system of claim 1, wherein the first section is encased in or completely surrounded by insulation, which forms the insulating barrier.
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