Targeting of antigen presenting cells with immunonanotherapeutics
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-039/00
A61K-047/00
A61K-047/48
출원번호
US-0046827
(2013-10-04)
등록번호
US-9308280
(2016-04-12)
발명자
/ 주소
Shi, Jinjun
Alexis, Frank
Iannacone, Matteo
Moseman, Elliott Ashley
Basto, Pamela
Langer, Robert S.
Farokhzad, Omid C.
von Andrian, Ulrich H.
Tonti, Elena
출원인 / 주소
Massachusetts Institute of Technology
대리인 / 주소
Pabst Patent Group LLP
인용정보
피인용 횟수 :
8인용 특허 :
168
초록▼
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface.
The present invention provides compositions and systems for delivery of nanocarriers to cells of the immune system. The invention provides nanocarriers capable of stimulating an immune response in T cells and/or in B cells. The invention provides nanocarriers that comprise an immunofeature surface. The nanocarriers are capable of targeting antigen presenting cells when administered to a subject. The invention provides pharmaceutical compositions comprising inventive nanocarriers. The present invention provides methods of designing, manufacturing, and using inventive nanocarriers and pharmaceutical compositions thereof.
대표청구항▼
1. A composition comprising: (a) polymeric particles formed from the self-assembly of a mixture of amphiphilic (hydrophobic-hydrophilic) polymers and amphiphilic polymers having at least one moiety bound to the hydrophilic ends of the amphiphilic polymers;(b) a B cell or T cell antigen;(c) an immuno
1. A composition comprising: (a) polymeric particles formed from the self-assembly of a mixture of amphiphilic (hydrophobic-hydrophilic) polymers and amphiphilic polymers having at least one moiety bound to the hydrophilic ends of the amphiphilic polymers;(b) a B cell or T cell antigen;(c) an immunostimulatory agent to promote tolerance to the antigen; and(d) a pharmaceutically acceptable excipient. 2. The composition of claim 1, wherein the surface of the polymeric particle further comprises a targeting moiety. 3. The composition of claim 1, wherein the polymeric particles further comprise an immunomodulatory agent. 4. The composition of claim 3, wherein the immunostimulatory agent, or antigen is (i) on the surface of the polymeric particle; or (ii) encapsulated within the polymeric particle. 5. The composition of claim 1, wherein the diameter of the polymeric particles is greater than 100 nm. 6. The composition of claim 1, wherein the pharmaceutically acceptable excipient is selected from solvents, dispersion media, diluents, or other liquid vehicles, dispersion or suspension aids, surface active agents, isotonic agents, thickening or emulsifying agents, preservatives, solid binders, and lubricants. 7. The composition of claim 1, wherein the composition targets a subcapsular sinus macrophage. 8. The composition of claim 1, wherein the composition targets a dendritic cell. 9. The composition of claim 1, wherein the composition does not substantially activate complement. 10. The composition of claim 1, wherein a first surface of the polymeric particles comprises a plurality of B cell antigen in an amount effective to provide a humoral response to the B cell antigen. 11. The composition of claim 10, wherein the composition does not substantially activate complement. 12. The composition of claim 1, wherein the polymeric particle comprises biodegradable polymers. 13. The composition of claim 1, wherein the polymeric particle comprises a biocompatible polymer that is a conjugate of a water soluble, non-adhesive polymer and a biodegradable hydrophobic polymer. 14. The composition of claim 13, wherein the biocompatible polymer is polyethylene glycol-poly(lactic acid-co-glycolic acid) (PEG-PLGA). 15. The composition of claim 1, wherein the polymeric particle comprises a conjugate of a polymer and a moiety selected from the group consisting of antigens, immunostimulatory agents, and targeting moieties. 16. The composition of claim 1, wherein the polymeric particle comprises polymers having the formula X-L1-Y-L2-Z, wherein X is a biodegradable hydrophobic polymer,Y is a water soluble, non-adhesive polymer,Z is selected from the group consisting of targeting moieties, immunomodulatory agents, immunostimulatory agents, and therapeutic or diagnostic agents, andL1 and L2 are bonds or linking molecules. 17. The composition of claim 1, wherein the polymeric particle comprises a molecule having the formula T-L1-X-L2-Y-L3-Z, wherein T is a T cell antigen,X is a biodegradable hydrophobic polymer,Y is a water soluble, non-adhesive polymer,Z is selected from the group consisting of targeting moieties, immunomodulatory agents, immunostimulatory agents, and therapeutic or diagnostic agents, andL1, L2, and L3 are bonds or linking molecules. 18. The composition of claim 12 wherein the biodegradable polymer is selected from the group consisting of polylactic acid (PLA), poly(glycolic acid) (PGA), and poly(lactic acid/glycolic acid) (PLGA). 19. The composition of claim 13, wherein the water soluble, non-adhesive polymer is selected from the group consisting of polyethylene glycol (PEG), polyethylene oxide (PEO), and copolymers thereof. 20. The composition of claim 1, wherein the polymeric particles are selected from the group consisting of microparticles and nanoparticles. 21. The composition of claim 1, wherein the immunostimulatory agent is an immunosuppressant or induces regulatory T cells. 22. The composition of claim 20, wherein the immunosuppressant is selected from the group consisting of cyclosporin, a steroid, methotrexate, and agent that interferes with T cell activation. 23. The composition of claim 20, wherein the immunostimulatory agent that induces regulatory T cells is selected from the group consisting of TGF-β, rapamycin or retinoic acid.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (168)
Gerster John F. (Woodbury MN) Crooks Stephen L. (Mahtomedi MN) Lindstrom Kyle J. (Houlton WI), 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines.
Schmitz,Juergen; Dzionek,Andrzej; Buck,David William, Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby.
Arimilli Murty N. ; Cundy Kenneth C. ; Dougherty Joseph P. ; Kim Choung U. ; Oliyai Reza ; Stella Valentino J., Antiviral phosphonomethoxy nucleotide analogs having increased oral bioavailability.
Hubbard Vance M. (Bedford) Brunson Welton K. (Bedford) Saied V. C. (Wichita Falls TX), Apparatus and method for raising a skin wheal and anesthetizing skin.
Mikos Antonios G. (Houston TX) Sarakinos Georgios (Boston MA) Vacanti Joseph P. (Winchester MA) Langer Robert S. (Newton MA) Cima Linda G. (Lexington MA), Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures.
Barrera Denise (Oakdale MN) Langer Robert S. (Newton MA) Lansbury ; Jr. Peter T. (Brookline MA) Vacanti Joseph P. (Winchester MA), Biodegradable polymers for cell transplantation.
Vacanti Joseph P. ; Vacanti Charles A. ; Langer Robert S., Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous struct.
D\Amore Patricia (Brookline MA) Leong Kam W. (Cambridge MA) Langer Robert S. (Somerville MA), Bioerodible articles useful as implants and prostheses having predictable degradation rates.
Skwierczynski Raymond D. ; Phares Kenneth R. ; Miller Richard L. ; Li Zheng Jane ; Jozwiakowski Michael J. ; Busch Terri F., Formulations and methods for treatment of mucosal associated conditions with an immune response modifier.
Dalton,James T.; Miller,Duane D.; Steiner,Mitchell S.; Veverka,Karen A., Halogenated selective androgen receptor modulators and methods of use thereof.
Swain Philip A. ; Schad Victoria C. ; Greenstein Julia L. ; Exley Mark A. ; Fox Barbara S. ; Powers Stephen P. ; Gefter Malcolm L., Hapten-carrier conjugates for use in drug-abuse therapy and methods for preparation of same.
Kedl,Ross M.; Griesgraber,George W.; Zarraga,Isidro Angelo E.; Wightman,Paul D., Immunostimulatory compositions and methods of stimulating an immune response.
Lilley Stephen J. (Sawston GBX) Taylor Hugh F. (Sawston GBX) Theobald David R. (Huntingdon GBX) Carlson Craig J. (Andover MA) Rosen David I. (Arlington MA) Johnson Thomas R. (Milford NH), Medical injection system and method, gas spring thereof and launching device using gas spring.
Tice Thomas R. ; Gilley Richard M. ; Eldridge John H. ; Staas Jay K., Method for delivering bioactive agents into and through the mucosally-associated lymphoid tissues and controlling their.
Bengs, Holger; Grande, Jürgen; Schuth, Silke; Böhm, Gitte; Schneller, Arnold; Brunner, Anette, Method for preparing smooth-surface spherical microparticles completely or partially made of at least one water-insoluble linear polysaccharide and microparticles produced according to this method.
Deming, Timothy J.; Yu, Miaoer; Curtin, Scott A.; Hwang, Jungyeon; Wyrsta, Michael D.; Nowak, Andrew; Seidel, Scott W., Methods and compositions for controlled polypeptide synthesis.
Jacobson Stephen C. ; Ramsey J. Michael, Microfabricated device and method for multiplexed electrokinetic focusing of fluid streams and a transport cytometry method using same.
Horoszewicz Julius S. (Williamsville NY), Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients.
Domb Abraham J. (Efrat ILX) Gref Ruxandra (Nancy FRX) Minamitake Yoshiharu (Ota JPX) Peracchia Maria T. (Parma ITX) Langer Robert S. (Newton MA), Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
Domb Abraham J.,ILX ; Gref Ruxandra,FRX ; Minamitake Yoshiharu,JPX ; Peracchia Maria Teresa,ITX ; Langer Robert S., Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A.; Garimella, Viswanadham; Li, Zhi, Nanoparticles having oligonucleotides attached thereto and uses therefor.
McKinnon ; Jr. Charles N. (Laguna Niguel CA) Peterson Steven F. (West Linn OR) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection device.
Peterson Steven F. (West Linn OR) McKinnon ; Jr. Charles N. (Laguna Niguel CA) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection methods and device.
Bischofberger Norbert W. ; Jones Robert J. ; Arimilli Murty N. ; Lin Kuei-Ying ; Louie Michael S. ; McGee Lawrence R. ; Prisbe Ernest J. ; Lee William A. ; Cundy Kenneth C., Nucleotide analogs.
Santus Giancarlo (Milan ITX) Bottoni Giuseppe (Bergamo ITX) Sala Giovanni (Verona ITX), Pharmaceutical controlled-release composition with bioadhesive properties.
Fessi Curt (Paris FRX) Devissaguet Jean-Philippe (Neuilly S/Seine FRX) Puisieux Francis (Maisons Alfort MO FRX) Thies Curt (St. Louis MO), Process for the preparation of dispersible colloidal systems of a substance in the form of nanoparticles.
Cech Thomas R. (Boulder CO) Zaug Arthur J. (Louisville CO) Been Michael D. (Boulder CO), RNA ribozyme polymerases, dephosphorylases, restriction endoribo-nucleases and methods.
Hirosue Sachiko ; Mueller Bernhard G.,CHX ; Langer Robert S. ; Mulligan Richard C., Sub-100nm biodegradable polymer spheres capable of transporting and releasing nucleic acids.
Larry Gold ; Michael Willis ; Tad Koch ; Steven Ringquist ; Kirk Jensen ; Brent Atkinson, Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands.
Gold Larry ; Willis Michael ; Koch Tad ; Ringquist Steven ; Jensen Kirk ; Atkinson Brent, Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex.
Gold Larry ; Willis Michael ; Koch Tad ; Ringquist Steven ; Jensen Kirk ; Atkinson Brent, Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex.
Kunz Lawrence L. ; Klein Richard A. ; Reno John M. ; Grainger David J.,GBX ; Metcalfe James C.,GBX ; Weissberg Peter L.,GBX ; Anderson Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.