System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/36
A61N-001/02
A61N-001/372
A61N-001/378
G06F-019/00
A61N-001/05
출원번호
US-0507989
(2014-10-07)
등록번호
US-9339651
(2016-05-17)
발명자
/ 주소
Meadows, Paul M.
Lima, Marcelo G.
Craig, Stanley R.
Zaidi, Faisal N.
Elias, Monir M.
출원인 / 주소
IMTHERA MEDICAL, INC.
대리인 / 주소
Morgan, Lewis & Bockius LLP
인용정보
피인용 횟수 :
9인용 특허 :
109
초록▼
A system for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle o
A system for controlling a position of a patient's tongue includes attaching at least one electrode to the patient's Hypoglossal nerve and applying an electric signal through the electrode to at least one targeted motor efferent located within the Hypoglossal nerve to stimulate at least one muscle of the tongue. The system may also include the use of more than one contact to target more than one motor efferent and stimulating more than one muscle. The stimulation load to maintain the position of the tongue may be shared by each muscle. The position of the patient's tongue may be controlled in order to prevent obstructive sleep apnea.
대표청구항▼
1. A system used for controlling a position of a patient's tongue, the system comprising: an electrode having a plurality of contacts, the plurality of contacts configured to be implanted proximate a Hypoglossal nerve, the electrode configured to apply one of at least one electric signal to one of a
1. A system used for controlling a position of a patient's tongue, the system comprising: an electrode having a plurality of contacts, the plurality of contacts configured to be implanted proximate a Hypoglossal nerve, the electrode configured to apply one of at least one electric signal to one of at least one targeted motor efferent groups located within a Hypoglossal nerve to stimulate at least one muscle of the tongue;an implantable pulse generator (IPG) coupled to the electrode, the IPG being programmable, independent of respiration cycle, to:assign each of the plurality of contacts to one of a plurality of functional groups,deliver at least two electric signals to the plurality of contacts in a pattern of electric frequencies;apply the at least two electric signals at a starting frequency,ramp the starting frequency downwards to a target frequency,maintain an amplitude of at least one electric signal of a first functional group of the plurality of functional groups at a target amplitude for a pre-determined amount of time and then replacing the at least one electric signal of the first functional group with at least one electric signal of a second functional group of the plurality of functional groups,ramp an amplitude of the at least one electric signal of the second functional group from an initial level up to the target amplitude, andramp the amplitude of the at least one electric signal of the second functional group from the target amplitude down to a rest amplitude. 2. The system of claim 1, wherein the IPG is programmable to assign the plurality of contacts to one of the plurality of functional groups. 3. The system of claim 2, wherein the IPG is programmable to sequence or interleave the plurality of functional groups. 4. The system of claim 2, wherein each functional group of the plurality of functional groups maintains an open airway in the patient and the first functional group includes at least one or more different muscles than the second functional group. 5. The system of claim 1, wherein the electrode includes six contacts. 6. The system of claim 1, wherein the contacts are each driven by their own independent current source. 7. The system of claim 1, wherein the electrode includes a cuff housing configured to wrap around a portion of the Hypoglossal nerve. 8. The system of claim 1, wherein the at least one electric signal is applied to the Hypoglossal nerve via an open loop system. 9. The system of claim 1, wherein the electrode is driven by multiple current sources. 10. A system for controlling a position of a patient's tongue, the system comprising: an electrode having a plurality of contacts, the plurality of contacts being configured to be implanted proximate a Hypoglossal nerve;an implantable pulse generator (IPG), the IPG being electronically coupled to the electrode;the IPG being programmed to deliver at least two electric signals to the plurality of contacts independent of respiration cycle;the IPG being programmed to apply the at least two electric signals at a starting frequency via the plurality of contacts to at least two targeted motor efferent groups located within the Hypoglossal nerve to stimulate at least two muscles of the tongue and then ramp the starting frequency downwards to a target frequency,wherein the IPG is further programmed to:assign each contact to one of a plurality of functional groups,keep an amplitude of at least one electric signal of a first functional group at a target amplitude for a pre-determined amount of time and then replacing the at least one electric signal of the first functional group with at least one electric signal of a second functional group of the plurality of functional groups,ramp an amplitude of the at least one electric signal of the second functional group from an initial level up to the target amplitude, andramp the amplitude of the at least one electric signal of the second functional group from the target amplitude down to a rest amplitude. 11. The system of claim 10, wherein the IPG is programmable to assign the plurality of contacts to one of the plurality of functional groups. 12. The system of claim 11, wherein each functional group of the plurality of functional groups maintains an open airway in the patient and the first functional group includes at least one or more different muscles than the second functional group. 13. The system of claim 10, wherein the electrode includes six contacts. 14. The system of claim 10, wherein the electrode is driven by multiple current sources. 15. A method for controlling a position of a patient's tongue, the method comprising: programming an implantable pulse generator (IPG), the IPG being electronically coupled to an electrode having a plurality of contacts, the plurality of contacts being implanted proximate a Hypoglossal nerve, to: assign each of the plurality of contacts to one of a plurality of functional groups,deliver at least two electric signals to the plurality of contacts independent of respiration cycle;apply the at least two electric signals at a starting frequency via the plurality of contacts to at least two targeted motor efferent groups located within the Hypoglossal nerve to stimulate at least two muscles of the tongue,ramp the starting frequency downwards to a target frequency,keep an amplitude of at least one electric signal of a first functional group of the plurality of functional groups at a target amplitude for a pre-determined amount of time and then replacing the at least one electric signal of the first functional group with at least one electric signal of a second functional group of the plurality of functional groups,ramp an amplitude of the at least one electric signal of the second functional group from an initial level up to the target amplitude, andramp the amplitude of the at least one electric signal of the second functional group from the target amplitude down to a rest amplitude. 16. The method of claim 15, wherein the IPG is programmable to assign the plurality of contacts to one of the plurality of functional groups. 17. The method of claim 16, wherein each functional group of the plurality of functional groups maintains an open airway in the patient and the first functional group includes at least one or more different muscles than the second functional group.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (109)
Bonnet, Jean-Luc, Active implantable medical device for treating sleep apnea syndrome by electrostimulation.
Kallok Michael J. (New Brighton MN) Markowitz H. Toby (Roseville MN), Airway feedback measurement system responsive to detected inspiration and obstructive apnea event.
Hrdlicka, Gregory Anthony; Grabinger, Scott; Stein, Marc; Mueller, Dave; Wesselink, Wilbert, Control of externally induced current in an implantable pulse generator.
Naples Gregory G. (Brecksville OH) Sweeney James D. (Cleveland Heights OH) Mortimer J. Thomas (Cleveland Heights OH), Implantable cuff, method of manufacture, and method of installation.
Gleason Curtis A. (Palo Alto CA) Stoller Marshall L. (San Francisco CA) Lue Tom F. (Millbrae CA) Schmidt Richard A. (San Rafael CA) Tanagho Emil A. (San Rafael CA), Implantable nerve stimulation device.
Durand, Dominique; Sahin, Mesut; Haxhiu, Musa A., Method and apparatus for closed-loop stimulation of the hypoglossal nerve in human patients to treat obstructive sleep apnea.
Testerman Roy L. (New Hope MN) Erickson Donald J. (Plymouth MN) Bierbaum Ralph W. (Coon Rapids MN), Method and apparatus for detecting and treating obstructive sleep apnea.
David M. Rapoport ; Robert G. Norman, Method and apparatus for optimizing the continuous positive airway pressure for treating obstructive sleep apnea.
Rapoport, David M.; Norman, Robert G.; Gruenke, Roger A., Method and apparatus for optimizing the continuous positive airway pressure for treating obstructive sleep apnea.
Testerman Roy L. (New Hope MN) Erickson Donald J. (Plymouth MN), Method and apparatus for providing a respiratory effort waveform for the treatment of obstructive sleep apnea.
Hansen, Gary L.; Bordewick, Steven S.; Bloom, Nicole Denise, Method and combination for treating sleep apnea using a cantilever mask attachment device.
Cho, Yong Kyun; Jensen, Donald N.; Mongeon, Luc R., Method for providing a therapy to a patient involving modifying the therapy after detecting an onset of sleep in the patient, and implantable medical device embodying same.
Hemming Michael Todd ; Peck Bradley C. ; Blow Brian A. ; Morrison Scott M. ; Schuelke Robert John, Microprocessor capture detection circuit and method.
Bolea, Stephen L.; Hoegh, Thomas B.; Persson, Bruce J.; Atkinson, Robert E.; Mazar, Scott T., Obstructive sleep apnea treatment devices, systems and methods.
Mondadori, Cesare; Sorensen, Stephen; Hitchcock, Janice M., Use of R(+) -α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piper idinemethanol for the treatment of sleep disorders.
Meadows, Paul M.; Lima, Marcelo G.; Craig, Stanley R.; Zaidi, Faisal N.; Elias, Monir M., System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.