Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/36
A61K-008/60
A61K-031/79
A61K-008/67
A61K-031/165
A61K-038/12
A61K-031/573
A61K-008/37
A61K-008/36
A61Q-017/04
A61K-008/04
A61K-008/73
A61K-009/00
A61K-031/00
A61K-031/4015
A61K-033/18
A61K-045/06
A61Q-019/00
출원번호
US-0604061
(2015-01-23)
등록번호
US-9345778
(2016-05-24)
발명자
/ 주소
Leshchiner, Adelya K.
Larsen, Nancy E.
Parent, Edward G.
출원인 / 주소
Luromed LLC
대리인 / 주소
Nutter McClennen & Fish LLP
인용정보
피인용 횟수 :
0인용 특허 :
20
초록▼
Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substance
Disclosed are compositions comprising crosslinked hyaluronic acid gels, preferably vinyl sulfone cross-linked hyaluronic acid known as hylan B gel, for use in topical cosmetic and dermatological formulations. The hylan B gel in these formulations provides prolonged delivery of incorporated substances to the surface of the skin, to provide a hydrated film on the surface of the skin, and to provide a substantive and compatible film on the skin.
대표청구항▼
1. A topical composition comprising: hylan B in a non-equilibrium form; and a low molecular weight substance deliverable topically, wherein hylan B is loaded by swelling with the substance, alone or in combination with a therapeutic agent, thereby the substance, alone or in combination with the ther
1. A topical composition comprising: hylan B in a non-equilibrium form; and a low molecular weight substance deliverable topically, wherein hylan B is loaded by swelling with the substance, alone or in combination with a therapeutic agent, thereby the substance, alone or in combination with the therapeutic agent, becomes entrapped within the hylan B gel matrix, and wherein the substance is selected from the group consisting of α, β, γ, or δ-hydroxy acid, an α-amino acid, a β-amino acid, a γ-amino acid, a δ-amino acid, glycerin, a vitamin, a vitamin derivative, a sugar, an essential oil, a water-soluble oil, a fragrance, a natural polymer, a synthetic polymer, a cross-linked natural polymer, a cross-linked synthetic polymer, a peptide, a protein, a polysaccharide or a nucleic acid. 2. The composition according to claim 1, wherein the substance is a polymer selected from the group consisting of a natural polymer, a synthetic polymer, a cross-linked natural polymer and a cross-linked synthetic polymer. 3. The composition according to claim 1, wherein the polymer is low molecular weight hyaluronic acid (HA). 4. The composition according to claim 1, wherein the therapeutic agent is an anti-inflammatory agent, an antiseptic agent, an anti-infective agent, a mucous membrane agent, a cleansing agent, a preservative, an astringent, an antihistamine, an analgesic, an anesthetic, an acne medication, an antifungal agent, an anti-pruritic agent, a hormone, a growth factor, a moisturizing agent, a sunscreen, a hyperpigmentation agent, an antioxidant or a nutritional agent. 5. The composition of claim 1, wherein hylan B is homogenized. 6. The composition of claim 5, wherein the composition is a gel slurry. 7. The composition of claim 4, wherein the antiseptic agent is povidone iodine. 8. A topical composition, comprising: 1) hylan B in a non-equilibrium form; 2) low molecular weight HA and 3) a therapeutic agent deliverable topically, wherein the therapeutic agent is selected from the group consisting of an anti-inflammatory agent, an antiseptic agent, an anti-infective agent, a mucous membrane agent, a cleansing agent, a preservative, an astringent, an antihistamine, an analgesic, an anesthetic, an acne medication, an antifungal agent, an anti-pruritic agent, a hormone, a growth factor, a moisturizing agent, a sunscreen, a hyperpigmentation agent, an antioxidant or a nutritional agent. 9. The composition of claim 8, wherein the composition is a gel slurry. 10. The composition of claim 8, wherein the antiseptic agent is povidone iodine. 11. The composition of claim 10, wherein the composition is formulated in the form of liquid drops for treatment of infections of the ear, nose or throat.
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이 특허에 인용된 특허 (20)
Leshchiner Edward (Cresskill NJ) Balazs Endre A. (Fort Lee NJ) Larsen Nancy E. (Highland Mills NY) Leshchiner Adelva (Cresskill NJ), Biocompatible viscoelastic gel slurries, their preparation and use.
Leshchiner Edward (Cresskill NJ) Balazs Endre A. (Fort Lee NJ) Larsen Nancy E. (Highland Mills NY) Leshchiner Adelya (Cresskill NJ), Biocompatible viscoelastic gel slurries, their preparation and use.
Leshchiner Edward (Cresskill NJ) Balazs Endre A. (Fort Lee NJ) Larsen Nancy E. (Highland Mills NY) Leshchiner Adelya (Cresskill NJ), Biocompatible viscoelastic gel slurries, their preparation and use.
Leshchiner, Adelya K.; Larsen, Nancy E.; Parent, Edward G., Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications.
Leshchiner, Adelya K.; Larsen, Nancy E.; Parent, Edward G., Composition using cross-linked hyaluronic acid for topical cosmetic and therapeutic applications.
Leshchiner, Adelya K.; Larsen, Nancy E.; Parent, Edward G., Cross-linked gels of hyaluronic acid with hydrophobic polymers and processes for making them.
Samour Carlos ; Krauser Scott F., Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery.
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