Biocompatible polyelectrolyte complexes and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/60
A61L-015/44
A61L-015/24
A61L-015/42
출원번호
US-0602628
(2015-01-22)
등록번호
US-9352068
(2016-05-31)
발명자
/ 주소
Schlenoff, Joseph B.
출원인 / 주소
The Florida State University Research Foundation, Inc.
대리인 / 주소
Armstrong Teasdale LLP
인용정보
피인용 횟수 :
0인용 특허 :
2
초록▼
An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of clo
An article comprising a polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers.
대표청구항▼
1. A wound protection system comprising a sealed container containing an aqueous solution and a permanently deformable article, the permanently deformable article comprising polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyt
1. A wound protection system comprising a sealed container containing an aqueous solution and a permanently deformable article, the permanently deformable article comprising polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, the polyelectrolyte complex further comprising a plurality of closed-shell pores, wherein said plurality of closed-shell pores is encapsulated in the polyelectrolyte complex and further wherein said plurality of pores have at least one average transverse dimension between about 100 nanometers and about 1000 micrometers, said pores comprise water, and the majority of said pores are non-interconnecting. 2. The wound protection system of claim 1 wherein the pores comprise additional large and/or small molecules and/or particles. 3. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises healing agents. 4. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises antirejection agents. 5. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises antibacterial and/or antiviral agents. 6. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises growth factors. 7. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises coagulation agents. 8. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises anticoagulation agents. 9. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises anti-inflammation agents. 10. The wound protection system of claim 1 wherein the polyelectrolyte complex further comprises one or more additives selected from the group consisting of metal oxide particles, talc, silicon oxide, zirconium oxide, inorganic minerals, clay minerals, carbon powder, graphite, carbon fibers, carbon nanotubes, polymer fibers, cellulose fibers, metal particles, metal fibers, magnetic nanoparticles and combinations thereof. 11. The wound protection system of claim 1 wherein the pores comprise polyelectrolyte. 12. The wound protection system of claim 1 wherein the negatively charged polyelectrolyte polymer is selected from the group consisting of poly(styrenesulfonic acid) (PSS), poly(2-acrylamido-2-methyl-1-propane sulfonic acid) (PAMPS), sulfonated poly(ether ether ketone) (SPEEK), poly(ethylenesulfonic acid), poly(methacryloxyethylsulfonic acid), their salts, and copolymers thereof; polycarboxylates such as poly(acrylic acid) (PAA) and poly(methacrylic acid), polyphosphates, polyphosphonates, and combinations thereof. 13. The wound protection system of claim 1 wherein the positively charged polyelectrolyte polymer is selected from the group consisting of poly(diallyldimethylammonium chloride) (PDADMA), poly(vinylbenzyltrimethylammonium) (PVBTA), ionenes, poly(acryloxyethyltrimethyl ammonium chloride), poly(methacryloxy(2-hydroxy)propyltrimethyl ammonium chloride), and copolymers thereof; polyelectrolytes comprising a pyridinium group such as poly(N-methylvinylpyridinium) (PMVP), including poly(N-methyl-2-vinylpyridinium) (PM2VP), other poly(N-alkylvinylpyridines), and copolymers thereof, protonated polyamines such as poly(allylaminehydrochloride) (PAH) and polyethyleneimine (PEI); polysulfoniums, polyphosphoniums, and combinations thereof. 14. The wound protection system of claim 1 wherein at least one of the polyelectrolytes is selected from the group consisting of proteins, polypeptides, enzymes, DNA, RNA, alginic acid, glycosaminoglycans, proteoglycans, chitosan, chitosan sulfate, cellulose sulfate, polysaccharides, dextran sulfate, carrageenin, guar, sulfonated lignin, polyglycolic acid carboxymethylcellulose and salts thereof. 15. The wound protection system of claim 1 wherein the polyelectrolytes of the article further comprise hydrogen bonding repeat units. 16. The wound protection system of claim 1 wherein the interpenetrating network has an equilibrium shear modulus greater than 1 kPa at 25° C. when immersed in a solution of 0.15 M NaCl in water. 17. The wound protection system of claim 1 wherein the interpenetrating network has an equilibrium shear modulus between about 1 kPa at 25° C. and about 300 MPa when immersed in a solution of 0.15 M NaCl in water. 18. A method of treating a wound, the method comprising: activating an article comprising a polyelectrolyte complex comprising an interpenetrating network comprising at least one predominantly positively charged polyelectrolyte and at least one predominantly negatively charged polyelectrolyte, wherein the polyelectrolyte complex further comprises a plurality of closed-shell pores, said plurality of closed-shell pores is encapsulated in the polyelectrolyte complex, and the plurality of pores having at least one average transverse dimension between about 100 nanometers and about 1000 micrometers, and further wherein said activating comprises a process selected from the group consisting of heating said article, increasing an internal salt concentration within said article from a first salt concentration to a second salt concentration wherein the second salt concentration is higher than the first salt concentration, and changing an internal pH of said article; andapplying the activated article to the wound. 19. The method of claim 18 wherein the article is contained with a sealed container, the sealed container further comprising an aqueous solution. 20. The method of claim 19 wherein the aqueous solution further comprises at least one charged salt or charged organic molecule. 21. The method of claim 19 wherein said activating occurs prior to breaking the seal. 22. The method of claim 18 wherein activation is performed by heating the article. 23. The method of claim 22 wherein the heating is performed by microwave irradiation, by an exothermic chemical reaction or mixing, or by induction heating. 24. The method of claim 18 wherein activation is performed by adding a salt. 25. The method of claim 18 wherein the activation is performed by changing the pH. 26. The method of claim 18 further comprising wrapping the hydrated, activated article circumferentially around a damaged limb, vessel, nerve, or bone and sealing the network back on itself. 27. The method of claim 18 wherein the interpenetrating network has an equilibrium shear modulus greater than 1 kPa at 25° C. when immersed in a solution of 0.15 M NaCl in water. 28. The method of claim 18 wherein the interpenetrating network has an equilibrium shear modulus between about 1 kPa at 25° C. and about 300 MPa when immersed in a solution of 0.15 M NaCl in water. 29. A polyelectrolyte complex comprising an interpenetrating network of at least one predominantly positively charged polyelectrolyte polymer and at least one predominantly negatively charged polyelectrolyte polymer, wherein the polyelectrolyte complex has equilibrium shear modulus between about 1 kPa and about 300 MPa at 25° C. when immersed in a solution of 0.15 M NaCl in water and further wherein the polyelectrolyte complex further comprises a plurality of closed-shell pores, the plurality of pores having at least one average transverse dimension between about 100 nanometer and about 1000 micrometers. 30. The polyelectrolyte complex of claim 29 further comprising an additive selected from the group consisting of a healing agent, an antiviral agent, a growth factor, an anticoagulation agent, a coagulation agent, paclitaxel, and any combination thereof.
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