[특허]Methods and compositions for treating viral diseases

Methods and compositions for treating viral diseases 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/553 A61K-031/517 A61K-031/404 C12Q-001/18
출원번호	US-0362993 (2012-12-06)
등록번호	US-9364484 (2016-06-14)
국제출원번호	PCT/US2012/068167 (2012-12-06)
국제공개번호	WO2013/086133 (2013-06-13)
발명자 / 주소	Einav, Shirit Barouch-Bentov, Rina Neveu, Gregory Zivav, Amotz
출원인 / 주소	The Board of Trustees of the Leland Stanford Junior University
대리인 / 주소	Roberts Foster LLP
인용정보	피인용 횟수 : 0 인용 특허 : 62

초록

The invention provides a method for treating viral infections and coinfections through the use of inhibitory agents that prevent a unique viral structural protein motifs from binding to host proteins from the clathrin adaptor proteins family and subsequently preventing viral replication.

대표청구항 ▼

1. A method of inhibiting infections by a Lentiviridae, HIV, HCV/HIV co-infection, Flaviviridae other than HCV, clathrin AP binding viruses other than Flaviviridae, or clathrin AP binding viruses other than HCV, the method comprising administering to a patient in need thereof an effective amount of sunitinib or a pharmaceutically acceptable salt of sunitinib. 2. The method of claim 1, wherein sunitinib or pharmaceutically acceptable salt of sunitinib inhibits binding of a protein from said virus comprising a YXXΦ or dileucine motif to a host μ subunit of clathrin adaptor protein (AP) complexes, and wherein said μ subunit is selected from the group consisting of μ subunits of clathrin AP1, AP2, AP3 and AP4 complexes. 3. The method of claim 2, wherein said μ subunit is selected from the group consisting of AP2M1, AP1M1, AP3M1 and AP4M1. 4. The method of claim 1, wherein sunitinib or pharmaceutically acceptable salt of sunitinib inhibits AAK1 or GAK. 5. The method of claim 1, wherein the method further comprises administering to the patient an effective amount of erlotinib, PKC-412, or pharmaceutically acceptable salts or combinations thereof. 6. The method of claim 1, wherein sunitinib or pharmaceutically acceptable salt of sunitinib inhibits infection by a Flaviviridae other than HCV in the patient. 7. The method of claim 6, wherein the Flaviviridae other than HCV comprises a Dengue virus. 8. The method of claim 1, wherein the viral load in the patient is reduced by at least about 10% compared to the viral load in the patient prior to administration of sunitinib or pharmaceutically acceptable salt of sunitinib.

이 특허에 인용된 특허 (62)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Methods and compositions for treating viral diseases 원문보기

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Methods and compositions for treating viral diseases 원문보기

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