Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits sec
Fluid transfer interfaces for transferring fluid into or out of vessels, namely flexible polymeric bags. The fluid transfer interfaces have a body for use in connection with a vessel, or combined therewith, one or more apertures extending through the body, and one or more fluid transfer conduits secured to the body by way of a cast seal and extending continuously and axially through the one or more apertures. Also disclosed is a vessel closure having one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure by a cast seal.
대표청구항▼
1. A fluid transfer interface for use with a vessel comprising: a body, wherein one or more apertures extend through the body,one or more fluid transfer conduits secured to the body, and a cast seal within an interior of the body and surrounding the fluid transfer conduits, the fluid transfer condui
1. A fluid transfer interface for use with a vessel comprising: a body, wherein one or more apertures extend through the body,one or more fluid transfer conduits secured to the body, and a cast seal within an interior of the body and surrounding the fluid transfer conduits, the fluid transfer conduits extending continuously and axially through the one or more apertures, the cast seal being cured after the one or more fluid transfer conduits are inserted through the one or more apertures,wherein when the fluid transfer interface is affixed to a vessel with an interior and exterior, the cast seal and body forms a closed aseptic seal between the interior of the vessel and the exterior of the vessel,wherein the fluid transfer interface further comprises a fluid control device connected to the one or more fluid transfer conduits, and wherein the cast seal comprises silicone. 2. The interface of claim 1 wherein the vessel is a flexible container. 3. The interface of claim 2 wherein the flexible container is a polymeric bag. 4. The interface of claim 1 wherein the silicone is selected from the group consisting of dimethyl silicone, methyl phenyl silicone, and diphenyl silicone. 5. The interface of claim 1 wherein the cast seal comprises perfluoropolyether. 6. The interface of claim 1 wherein the body is threadedly connected to a vessel. 7. The interface of claim 1 wherein the body is mechanically connected to a vessel. 8. The interface of claim 7 wherein the mechanical connection is a clamp connection. 9. The interface of claim 1 wherein the body is welded to a vessel. 10. The interface of claim 1 wherein the body is bonded with a vessel. 11. The interface of claim 1 wherein the body is a singular unit with a vessel. 12. The interface of claim 1 wherein the interface is pre-sterilized. 13. The interface of claim 1 wherein the fluid control device is selected from the group consisting of a pinch valve, check valve, clamp, and plug. 14. The interface of claim 1 further comprising a sensor extending through one of the apertures in the body. 15. The interface of claim 1 wherein the fluid control device is a deformable sleeve. 16. The interface of claim 15 wherein the deformable sleeve comprises a sleeve adhesively attached to and surrounding a portion of the flexible tubing, wherein the sleeve and adhesive are formed of materials having plasticity such that pressure applied to the sleeve causes the sleeve and adhesive to deform about and seal the flexible tubing and upon continued application of pressure to the sleeve, the sleeve, adhesive, and flexible tubing are cut and the sleeve retains a deformed shape substantially sealing the tubing. 17. The interface of claim 1 wherein the one or more fluid transfer conduits comprises a thermoset. 18. The interface of claim 17 wherein the thermoset comprises silicone. 19. The interface of claim 18 wherein the silicone is selected from the group consisting of dimethyl silicone, methyl phenyl silicone, and diphenyl silicone. 20. The interface of claim 1 wherein the one or more fluid transfer conduits comprises a thermoplastic. 21. The interface of claim 20 wherein the thermoplastic is selected from the group consisting of C-Flex®, block copolymers of styrene-ethylene-butylene-styrene, PureWeld, PVC, polyolefins, or polyethylene. 22. The interface of claim 1 wherein the one or more fluid transfer conduits extend from the interior of a bioreactor vessel through the interface to the exterior of a bioreactor vessel. 23. The interface of claim 1 wherein one or more anchors secure the one or more fluid transfer conduits to the body. 24. A vessel closure comprising one or more fluid transfer conduits extending through the closure, the fluid transfer conduits affixed to the closure, and a cast seal within an interior of the closure and surrounding the fluid transfer conduits, the cast seal being cured after the one or more fluid transfer conduits are inserted through the closure, wherein when the closure is affixed to a vessel with an interior and exterior, the cast seal and closure form a closed aseptic seal between the interior of the vessel and the exterior of the vessel,wherein the fluid transfer interface further comprises a fluid control device connected to the one or more fluid transfer conduits, andwherein the cast seal comprises silicone. 25. A combination of a fluid transfer interface and two vessels comprising: a body connected to a first vessel having an interior and exterior, wherein one or more apertures extend through the body,one or more fluid transfer conduits secured to the body and extending continuously and axially through the one or more apertures, a cast seal within an interior of the body connected to the first vessel and surrounding the fluid transfer conduits, the cast seal being cured after the one or more fluid transfer conduits are inserted through the one or more apertures, and at least a second vessel connected to the one or more fluid transfer conduits, wherein when the fluid transfer interface is affixed to the first vessel, the cast seal and body form a closed aseptic seal between the interior of the first vessel and the exterior of the vessel,wherein the fluid transfer interface further comprises a fluid control device connected to the one or more fluid transfer conduits, andwherein the cast seal comprises silicone. 26. The combination of claim 25 wherein the combination is pre-sterilized. 27. The fluid transfer interface of claim 1, wherein there are at least two fluid transfer conduits wherein at least one fluid transfer conduit is a thermoplastic and at least one fluid transfer conduit is a thermoset. 28. The interface of claim 23 wherein the cast seal is bonded to the one or more anchors. 29. The interface of claim 28 wherein the cast seal is adhesively attached to the body. 30. The interface of claim 23 wherein the one or more anchors engage an interior and an exterior of the body. 31. The interface of claim 1 wherein the one or more fluid conduits are surrounded by and adhesively secured to a sleeve at the location the one or more fluid conduits extend through the one or more apertures in the body.
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