[미국특허]
Fascia fibrous compositions and methods for their use and manufacture
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/35
D01C-003/00
출원번호
US-0204346
(2014-03-11)
등록번호
US-9446077
(2016-09-20)
발명자
/ 주소
Southard, Matthew
Samaniego, Adrian C.
Stevens, Peter J.
출원인 / 주소
AlloSource
대리인 / 주소
Kilpatrick Townsend & Stockton LLP
인용정보
피인용 횟수 :
1인용 특허 :
65
초록▼
Embodiments of the present invention encompass fascia, fat, and dermis fibrous compositions, and methods for their manufacture and use. In a first aspect, embodiments of the present invention encompass methods for obtaining a fascia fiber for use in producing a biotextile. Exemplary methods may incl
Embodiments of the present invention encompass fascia, fat, and dermis fibrous compositions, and methods for their manufacture and use. In a first aspect, embodiments of the present invention encompass methods for obtaining a fascia fiber for use in producing a biotextile. Exemplary methods may include treating a cadaveric fascia tissue with acetone, and obtaining the fascia fibers from the treated fascia tissue. In some cases, methods may include processing the fascia fibers to produce the fibrous fascia biotextile.
대표청구항▼
1. A method of producing a fibrous fascia biotextile composition, the method comprising: obtaining a deceased donor fascia tissue;treating the deceased donor fascia tissue with acetone;obtaining intact fascia fibers from the treated deceased donor fascia tissue, wherein the intact fascia fibers have
1. A method of producing a fibrous fascia biotextile composition, the method comprising: obtaining a deceased donor fascia tissue;treating the deceased donor fascia tissue with acetone;obtaining intact fascia fibers from the treated deceased donor fascia tissue, wherein the intact fascia fibers have a diameter from 5 to 200 microns and a length greater than 20 cm; andprocessing the intact fascia fibers to produce the fibrous fascia biotextile using a textile or threadmaking process. 2. The method of claim 1, wherein the method further comprises washing and clearing the deceased donor fascia tissue of biological fluids. 3. The method of claim 1, wherein the method further comprises exposing the deceased donor fascia tissue to a basic solution and an organic dehydrating solution before treating the deceased donor fascia tissue with acetone. 4. The method of claim 1, wherein the deceased donor fascia tissue comprises adipose oil and the method further comprises removing substantially all of the adipose oil. 5. The method of claim 1, wherein processing the intact fascia fibers comprises weaving, bundling, spinning, or carding. 6. The method of claim 1, wherein the fibrous fascia biotextile comprises sheets, bundles, or other three dimensional fibrous structures. 7. The method of claim 1, wherein the fibrous fascia biotextile comprises movable fiber configurations. 8. The method of claim 1, wherein the method further comprises adding a biological component selected from the group consisting of a stem cell composition, a polymer based support, a polymer based skeleton, and a bone construct to the fibrous fascia biotextile. 9. The method of claim 1, wherein the fibrous fascia biotextile comprises sutures, mats, felts, or pads for use in surgery. 10. The method of claim 1, wherein the fibrous fascia biotextile comprises gauzes, meshes, implants for use in facial ligament or tendon reconstruction, ligament/tendon bundles, fabric wraps, or fabric clamps. 11. The method of claim 1, further comprising washing the deceased donor fascia tissue with hexane after treating the deceased donor fascia tissue with acetone. 12. The method of claim 1, wherein treating the deceased donor fascia tissue with acetone comprises a plurality of washings with acetone. 13. The method of claim 1, wherein treating the deceased donor fascia tissue with acetone comprises treating the deceased donor tissue with a single organic solvent consisting of acetone. 14. The method of claim 13, further comprising washing the deceased donor fascia tissue with hexane after treating the deceased donor fascia tissue with acetone. 15. The method of claim 1, wherein the intact fascia fibers are non-denatured. 16. The method of claim 1, wherein processing the intact fascia fibers to produce the fibrous fascia biotextile comprises using the textile process. 17. The method of claim 1, wherein processing the intact fascia fibers to produce the fibrous fascia biotextile comprises using the threadmaking process. 18. The method of claim 1, wherein processing the intact fascia fibers comprises weaving. 19. The method of claim 1, wherein processing the intact fascia fibers comprises bundling. 20. The method of claim 1, wherein processing the intact fascia fibers comprises spinning. 21. The method of claim 1, wherein processing the intact fascia fibers comprises carding. 22. The method of claim 1, wherein the fibrous fascia biotextile comprises sheets. 23. The method of claim 1, wherein the fibrous fascia biotextile comprises bundles. 24. The method of claim 1, wherein the fibrous fascia biotextile comprises three dimensional fibrous structures. 25. The method of claim 1, wherein the method further comprises adding a stem cell composition to the fibrous fascia biotextile. 26. The method of claim 1, wherein the method further comprises adding a polymer based support to the fibrous fascia biotextile. 27. The method of claim 1, wherein the method further comprises adding a polymer based skeleton to the fibrous fascia biotextile. 28. The method of claim 1, wherein the method further comprises adding a bone construct to the fibrous fascia biotextile. 29. The method of claim 1, wherein the fibrous fascia biotextile comprises gauzes. 30. The method of claim 1, wherein the fibrous fascia biotextile comprises meshes. 31. The method of claim 1, wherein the fibrous fascia biotextile comprises implants for use in facial ligament or tendon reconstruction. 32. The method of claim 1, wherein the fibrous fascia biotextile comprises ligament bundles. 33. The method of claim 1, wherein the fibrous fascia biotextile comprises tendon bundles. 34. The method of claim 1, wherein the fibrous fascia biotextile comprises fabric wraps. 35. The method of claim 1, wherein the fibrous fascia biotextile comprises fabric clamps.
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