[미국특허]
Devices and methods for controlling tremor
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/08
A61N-001/36
A61N-001/04
A61N-001/02
A61N-001/18
출원번호
US-0805385
(2015-07-21)
등록번호
US-9452287
(2016-09-27)
발명자
/ 주소
Rosenbluth, Kathryn H.
Delp, Scott Lee
Paderi, John
Rajasekhar, Vijaykumar [[Vijay]]
Altman, Tahel
출원인 / 주소
Cala Health, Inc.
대리인 / 주소
Shay Glenn LLP
인용정보
피인용 횟수 :
7인용 특허 :
134
초록▼
A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or c
A peripheral nerve stimulator can be used to stimulate a peripheral nerve to treat essential tremor, Parkinson tremor, and other forms of tremor. The peripheral nerve stimulator can be either a noninvasive surface stimulator or an implanted stimulator. Stimulation can be electrical, mechanical, or chemical. Stimulation can be delivered using either an open loop system or a closed loop system with feedback.
대표청구항▼
1. A wearable device for treating tremor in a patient, the device comprising: a decision unit;a first peripheral nerve effector, comprising at least one stimulation electrode configured to be positioned to modulate an afferent nerve pathway; andat least one biomechanical sensor configured to measure
1. A wearable device for treating tremor in a patient, the device comprising: a decision unit;a first peripheral nerve effector, comprising at least one stimulation electrode configured to be positioned to modulate an afferent nerve pathway; andat least one biomechanical sensor configured to measure movement of the patient's extremity to characterize one or more features of the tremor, the one or more features of the tremor selected from the group consisting of tremor frequency, tremor period, and tremor magnitude;wherein the decision unit comprises a processor and a memory for storing instructions that, when executed by the processor, cause the device to: measure the movement of the patient's extremity using the measurement unit to generate motion data;determine one or more of a tremor frequency, period and magnitude based on an analysis of the motion data;set one or more parameters of a first electrical stimulus based on one or more of the tremor frequency, period or magnitude; anddeliver the first electrical stimulus to a first afferent nerve through the first peripheral nerve effector to reduce tremor in the patient's extremity by reducing synchronicity in a brain network and modifying the patient's neural network dynamics. 2. The device of claim 1, further comprising a second peripheral nerve effector in communication with the decision unit, the second peripheral nerve effector comprising at least one electrode, wherein the memory for storing instructions that, when executed by the processor, further cause the decision unit to deliver a second electrical stimulus to a second afferent nerve in the patient's extremity through the second peripheral nerve effector. 3. The device of claim 1, wherein the first peripheral nerve effector comprises a plurality of electrodes arranged in linear array. 4. The device of claim 1, wherein the instructions, when executed by the processor, cause the decision unit to deliver a second electrical stimulus offset in time from the first electrical stimulus by a predetermined fraction or multiple of a period of the tremor. 5. The device of claim 1, wherein the analysis of the motion data comprises a frequency analysis of the spectral power of the movement data. 6. The device of claim 5, wherein the frequency analysis is restricted to between about 4 to 12 Hz. 7. The device of claim 1, wherein the memory for storing instructions that, when executed by the processor, further cause the decision unit to deliver the first electrical stimulus as a plurality of bursts of electrical stimulation having a variable temporal delay between the bursts of electrical stimulation. 8. The device of claim 1, wherein the electrode is adapted to deliver the first electrical stimulus through the patient's skin. 9. The device of claim 1, wherein the at least one biomechanical sensor is located in the decision unit. 10. The device of claim 1, wherein the first electrical stimulus has an amplitude less than about 10 mA and a frequency from about 10 to 5000 Hz. 11. The device of claim 1, wherein the first peripheral nerve effector comprises a plurality of electrodes and wherein the memory storing instructions that, when executed by the processor, further cause the decision unit to select a subset of the plurality of electrodes based on a position of first peripheral nerve effector on the patient's extremity, wherein the selection of the subset of the plurality of electrodes occurs each time the first peripheral nerve effector is positioned or repositioned on the extremity. 12. The device of claim 1, wherein the analysis of the motion data is done on a predetermined length of time of the motion data. 13. The device of claim 1, wherein the memory for storing instructions that, when executed by the processor, further cause the decision unit to set parameters of the first electrical stimulus based on the determined tremor magnitude. 14. The device of claim 1, wherein the decision unit is configured to wirelessly provide power to, or communicate with, the first peripheral nerve effector. 15. A method of reducing tremor in a patient, the method comprising: measuring one or more characteristics of the tremor using one or more biomechanical sensors worn on one of the patient's extremities;positioning a first peripheral nerve effector on the patient's skin to stimulate a first afferent nerve;delivering a first electrical nerve stimulation signal from an effector to the first afferent nerve through the first peripheral nerve effector;modifying the patient's neural network dynamics by reducing synchronicity in a brain network with the first electrical nerve stimulation signal to the first afferent nerve; andreducing the tremor amplitude. 16. The method of claim 15, further comprising dephasing the synchronicity of a neural network in the patient's brain. 17. The method of claim 15, further comprising: sensing motion of the patient's extremity using the one or more biomechanical sensors to generate motion data; anddetermining tremor information from the motion data. 18. The method of claim 17, wherein the step of delivering the first electrical nerve stimulation signal is based in part on the tremor information. 19. The method of claim 17, wherein the tremor information comprises tremor frequency, phase, and amplitude. 20. The method of claim 15, wherein the step of delivering the first electrical nerve stimulation signal comprises delivering a plurality of bursts of stimulation having a variable temporal delay between the bursts of stimulation. 21. The method of claim 15, further comprising: placing a second peripheral nerve effector at a second location relative to a second afferent nerve; anddelivering a second stimulus to the second afferent nerve through the second peripheral nerve effector. 22. The method of claim 21, further comprising determining a period of the patient's tremor, wherein the step of delivering the second electrical nerve stimulation signal comprises offsetting delivery of the second electrical nerve stimulation signal from the delivery of the first electrical nerve stimulation signal by a predetermined fraction or multiple of a period of the tremor. 23. The method of claim 21, wherein the first afferent nerve and the second afferent nerve are adjacent nerves. 24. The method of claim 21, wherein the first afferent nerve is the median nerve and the second afferent nerve is the ulnar or radial nerve. 25. The method of claim 15, wherein the first afferent nerve carries proprioceptive information from the patient's extremity. 26. The method of claim 15, wherein the step of determining the duration of effect comprises analyzing multiple stimuli applications applied over a predetermined period of time. 27. The method of claim 15, further comprising determining an activity profile for the patient, the activity profile including data regarding caffeine and alcohol consumption.
Kim, Youn-ho; Song, Jong-keun; Kim, Dong-wook; Shin, Kun-soo; Yeo, Hyung-sok; Bae, Sang-kon; Jang, Woo-young; Kim, Ji-hoon, Apparatus and method of processing plurality of biologic signals.
Rossi, Lorenzo; Marceglia, Sara Renata Francesca; Mrakic-Sposta, Simona; Bertolasi, Laura, Apparatus for the controlled prescription and administration of transcranial direct current stimulation treatments in humans.
Asada, Yuji, Body motion balance detection device, body motion balance detection program, body motion balance detection method, and body motion balance diagnosis method.
Simon, Bruce J.; Errico, Joseph P.; Raffle, John T., Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient.
Baru Fassio, Marcelo Daniel; Hoffer, Joaquin Andres; Calderon, Enric; Jenne, Gary Bernhard; Calderon, Albert, Fully implantable nerve signal sensing and stimulation device and method for treating foot drop and other neurological disorders.
Whitehurst, Todd K.; McGivern, James P.; Mann, Carla M., Fully implantable neurostimulator for autonomic nerve fiber stimulation as a therapy for urinary and bowel dysfunction.
Prochazka Arthur (Edmonton CAX) Wieler Marguerite (Edmonton CAX) Kenwell Zoltan R. (Edmonton CAX) Gauthier Michel J. A. (Edmonton CAX), Garment for applying controlled electrical stimulation to restore motor function.
Silberstone Leon M. (LaJolla CA) Halleck Michael E. (Longmont CO), High frequency high intensity transcutaneous electrical nerve stimulator and method of treatment.
Loeb, Gerald E.; Richmond, Francis J. R.; Mann, Carla M.; Faltys, Michael A.; Whitehurst, Todd K.; McGivern, James P., Implantable stimulator system and method for treatment of incontinence and pain.
Possover, Marc, Laparoscopic transpelveo-abdominal implantation of multiple channel electrodes to the endopelvic portions of the pudendus and sciatic nerves.
Gozani, Shai N.; Neverov, Marie; Fendrock, Charles; Williams, Michael, Method and apparatus for determining optimal neuromuscular detection sites, novel diagnostic biosensor array formed in accordance with the same, and novel method for testing a patient using the novel diagnostic biosensor array.
Boveja, Birinder R.; Widhany, Angely, Method and apparatus for electrical stimulation adjunct (add-on) treatment of urinary incontinence and urological disorders using an external stimulator.
DiLorenzo, Daniel John, Method and apparatus for neuromodulation and physiologic modulation for the treatment of metabolic and neuropsychiatric disease.
Silverstone Leon M., Method and apparatus for treating chronic pain syndromes, tremor, dementia and related disorders and for inducing electroanesthesia using high frequency, high intensity transcutaneous electrical nerv.
Perry Robert E. (32 Abbott St. South Weymouth MA 02190) Perry Linda (38 Hemlock Rd. West Roxbury MA 02132), Method and device for managing freezing gait disorders.
Boveja,Birinder R.; Widhany,Angely, Method and system for providing pulsed electrical stimulation to sacral plexus of a patient to provide therapy for urinary incontinence and urological disorders.
Alwan, Majd; Felder, Robin A.; Kell, Steven W.; Dalal, Siddharth, Method and system for the derivation of human gait characteristics and detecting falls passively from floor vibrations.
Lue Tom (Millbrae CA) Tanagho Emil A. (San Rafael CA) Schmidt Richard (San Francisco CA) Gleason Curtis A. (Palo Alto CA), Method for stimulating pelvic floor muscles for regulating pelvic viscera.
Hudson, John L.; Kiss, István Z.; Rusin, Craig G.; Kori, Hiroshi, Method, system and computer program product for controlling complex rhythmic systems.
Spinelli; Michele, Malaguti; Sylvia, Gerber; Martin T., Giardiello; Gianluca, Method, system and device for treating disorders of the pelvic floor by means of electrical stimulation of the pudendal and associated nerves, and the optional delivery of drugs in association therewith.
Stephen A. Michelson ; Jeffrey S. Mannheimer ; Robert Leon ; Osvaldo D. Romero ; Jerald A. Selevan, Miniature wireless transcutaneous electrical neuro or muscular-stimulation unit.
Simon, Bruce J.; Errico, Joseph P.; Raffle, John T., Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence.
Goetz, Steven M.; Houchins, Andrew H.; Keacher, Jeffrey T.; King, Gary W.; Heruth, Kenneth T.; Testerman, Roy L.; Lee, Michael T.; Torgerson, Nathan A.; Nolan, Joseph J., Shifting between electrode combinations in electrical stimulation device.
Tanagho Emil A. (San Rafael CA) Schmidt Richard A. (San Francisco CA) Gleason Curtis A. (Palo Alto CA) Lue Tom F. (Millbrae CA), System for controlling bladder evacuation.
Gliner,Bradford Evan, Systems and methods for enhancing or optimizing neural stimulation therapy for treating symptoms of Parkinson's disease and/or other movement disorders.
Grill, Warren M.; Gustafson, Kenneth J.; Creasey, Graham H., Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selective physiologic responses.
Molnar, Gregory F.; Gill, Steven S.; Miesel, Keith A.; Lent, Mark S.; Denison, Timothy J.; Panken, Eric J.; Wahlstrand, Carl D.; Werder, Jonathan C., Therapy control based on a patient movement state.
Van Den Eerenbeemd, Jacobus Maria Antonius; Brokken, Dirk; Hoogenstraaten, Willem Franciscus Johannes; Reusens, Roel, Wearable device and system for a tamper free electric stimulation of a body.
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