Method and apparatus for analyzing acetone in breath
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-033/64
A61B-005/08
G01N-033/50
G01N-033/497
A61B-005/097
G01N-021/78
A61B-005/00
출원번호
US-0400911
(2013-05-15)
등록번호
US-9518991
(2016-12-13)
국제출원번호
PCT/US2013/000135
(2013-05-15)
국제공개번호
WO2013/172873
(2013-11-21)
발명자
/ 주소
Ahmad, Lubna M.
Satterfield, Brent
Martineau, Rhett
출원인 / 주소
Invoy Technologies, LLC
대리인 / 주소
Knobbe, Martens, Olson & Bear, LLP
인용정보
피인용 횟수 :
1인용 특허 :
6
초록▼
Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic tha
Methods and devices are provided for analyzing acetone in breath. One such method comprises disposing a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level. It also comprises pre-storing a liquid nitroprusside solution within the breath analysis device separately from the reactant. The method further comprises using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product and, after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level.
대표청구항▼
1. A method for sensing acetone in breath using a breath analysis device, the method comprising: providing a breath analysis device having a reactant in a reaction zone, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic
1. A method for sensing acetone in breath using a breath analysis device, the method comprising: providing a breath analysis device having a reactant in a reaction zone, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level;a liquid nitroprusside solution disposed within the breath analysis device separately from the reactant;using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the reactant to form a reaction product;after the reaction product has been formed, using the breath analysis device to cause the nitroprusside solution to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level; andusing the breath analysis device to detect the change in the optical characteristic to sense the acetone in the breath. 2. A method as recited in claim 1 wherein causing the nitroprusside solution to contact the reaction product has an optical characteristic that is at a second reference level, and further wherein causing the nitroprusside solution to react with the reaction product facilitates a change in the optical characteristic of the reaction zone relative to the second reference level. 3. A method as recited in claim 1, wherein the surface comprises a silica gel. 4. A method as recited in claim 1, wherein the surface comprises a plurality of silica gel beads. 5. The method as recited in claim 4, wherein the silica gel beads have a size distribution between 270 and 100 mesh. 6. A method as recited in claim 1, wherein the providing a breath analysis device having a reactant in the reaction zone step comprises providing a device in which the reactant is maintained in an alkaline environment. 7. A method as recited in claim 1, wherein the providing a breath analysis device having a reactant in the reaction zone step comprises providing a device in which the reactant is maintained in the absence of volatile acid. 8. A method as recited in claim 1, wherein the providing a breath analysis device having a reactant in the reaction zone step comprises providing a device in which the primary amine is quenched with a non-volatile acid. 9. A method as recited in claim 1, wherein the providing a breath analysis device having a reactant in the reaction zone step comprises providing a device in which the primary amine is quenched with sulfuric acid. 10. A method as recited in claim 1, wherein the liquid nitroprusside solution within the breath analysis device consists essentially of a non-alkaline solution. 11. A method as recited in claim 1, wherein the liquid nitroprusside solution does not include a substance with a base dissociation constant less than 6. 12. A method as recited in claim 1, comprising quenching the liquid nitroprusside solution so that the liquid nitroprusside solution has a pH of less than 8. 13. A method as recited in claim 1, comprising, quenching the liquid nitroprusside solution so that the liquid nitroprusside solution has a pH of less than 7. 14. A method as recited in claim 1 wherein the liquid nitroprusside solution is stored in the absence of ambient light. 15. A method for sensing acetone in breath using a breath analysis device, the method comprising: providing a breath analysis device comprising a reactant in a reaction zone within the breath analysis device, wherein the reactant comprises a primary amine disposed on a surface, and wherein the reaction zone has an optical characteristic that is at a reference level; anda liquid nitroprusside solution in the breath analysis device in a non-alkaline environment;using the breath analysis device to cause the breath to contact the reactant in the reaction zone so that the acetone in the breath reacts with the primary amine to form a reaction product;after the reaction product has been formed, using the breath analysis device to cause the nitroprusside to contact and react with the reaction product and to facilitate a change in the optical characteristic of the reaction zone relative to the reference level; andusing the breath analysis device to detect the change in the optical characteristic and to sense the acetone in the breath. 16. A method as recited in claim 15, comprising quenching the primary amine on the surface with a non-volatile acid so that the primary amine on the surface has a pH that is less than 8. 17. A method as recited in claim 15, comprising quenching the primary amine on the surface with a non-volatile acid so that the primary amine on the surface has a pH that is less than 7. 18. A method as recited in claim 16, wherein the non-volatile acid comprises sulfuric acid. 19. A method as recited in claim 15, comprising pre-storing the nitroprusside separately from the reactant prior to the causing of the nitroprusside to contact the primary amine reaction product step. 20. A method as recited in claim 19, wherein the pre-storing of the nitroprusside separately from the reactant comprises using a gas-tight barrier. 21. A method as recited in claim 15, wherein the nitroprusside solution is stored in the absence of a substance with a base dissociation constant less than 6. 22. A method as recited in claim 15, wherein the nitroprusside is quenched with a non-volatile acid. 23. A method as recited in claim 22, wherein the non-volatile acid comprises sulfuric acid. 24. A method as recited in claim 15, wherein the nitroprusside solution is quenched with a non-volatile acid so that the environment has a pH is below 8. 25. A method as recited in claim 15, wherein the nitroprusside is quenched with a non-volatile acid so that the environment has a pH is below 7. 26. A method as recited in claim 15, wherein: the surface upon which the primary amine is disposed comprises a first surface;the nitroprusside is disposed on a second surface other than the first surface;the first and second surfaces are intermingled prior to the causing of the nitroprusside to contact the reaction product; andthe causing of the nitroprusside to contact and react with the reaction product comprises dispensing a liquid developer solution to contact the first and second surfaces. 27. A method as recited in claim 15, wherein: the nitroprusside is coupled to the reactant prior to the causing of the nitroprusside to contact the primary amine product;the reactant and the nitroprusside are disposed in the non-alkaline environment; andthe causing of the nitroprusside to contact and react with the reaction product comprises dispensing a liquid developer solution to contact the nitroprusside and the reaction product.
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이 특허에 인용된 특허 (6)
Kundu Samar K. (Libertyville IL) George Richard W. (Libertyville IL) March Steven C. (Libertyville IL) Rutnarak Sangvorn (Long Grove IL), Breath component monitoring device.
Kundu Samar K. (Libertyville IL) George Richard W. (Libertyville IL) March Steven C. (Libertyville IL) Rutnarak Sangvorn (Long Grove IL), Method and device for ketone measurement.
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