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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0152428 (2014-01-10) |
| 등록번호 | US-9533151 (2017-01-03) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 392 |
Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period t
Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device by applying an electrical signal characterized by having a number of pulses per microburst, an interpulse interval, a microburst duration, and an interburst period to a portion of a cranial nerve of said patient, wherein at least one of the number of pulses per microburst, the interpulse interval, the microburst duration, or the interburst period is selected to enhance cranial nerve evoked potentials.
1. A method of treating congestive heart failure using an implantable medical device, the method comprising: applying a first electrical signal during a first stimulation period and applying a second electrical signal during a second stimulation period to a cranial nerve, wherein:the first electrica
1. A method of treating congestive heart failure using an implantable medical device, the method comprising: applying a first electrical signal during a first stimulation period and applying a second electrical signal during a second stimulation period to a cranial nerve, wherein:the first electrical signal comprises: a pulse frequency;a first pulse width; anda first pulse amplitude; andthe second electrical signal comprises: a plurality of microbursts applied at a microburst frequency, wherein at least one microburst comprises a plurality of microburst pulses applied during a first microburst duration, wherein each microburst pulse comprises: a second pulse width;a pulse shape; anda second pulse amplitude;wherein the first pulse width is different than the second pulse width and the first pulse amplitude is different than the second pulse amplitude and wherein a microburst has a microburst characteristic where the microburst characteristic includes at least one of: a number of electrical pulses being between 2 to 25 and a microburst duration of 10 milliseconds to 1 second. 2. The method of claim 1, wherein the first stimulation period and the second stimulation period are each a period of time. 3. The method of claim 1, wherein the first stimulation period comprises a predetermined number of pulses. 4. The method of claim 1, wherein the second stimulation period comprises a predetermined number of microbursts. 5. The method of claim 1, wherein the first stimulation period and the second stimulation period overlap. 6. The method of claim 1, wherein at least one of the first stimulation period and the second stimulation period is triggered based on a triggering event. 7. The method of claim 1, wherein each microburst comprises between 2 and 15 microburst pulses and the first microburst duration is from 10 milliseconds to 80 milliseconds. 8. The method of claim 1, wherein the cranial nerve is selected from: a vagus nerve;a trigeminal nerve; anda glossopharyngeal nerve. 9. An implantable medical device for treating congestive heart failure, the comprising: a controller, wherein the controller comprises a processor and a memory;a power supply; anda stimulation unit, wherein the stimulation unit being configured to apply a first electrical signal during a first stimulation period and a second electrical signal during a second stimulation period to a cranial nerve, wherein:the first electrical signal comprises: a first pulse frequency;a first pulse width;a first pulse shape; anda first pulse amplitude; andthe second electrical signal comprises: a plurality of microbursts applied at a first microburst frequency, wherein at least one microburst comprises a plurality of microburst pulses applied during a firstmicroburst duration, wherein each microburst pulse comprises:a second pulse width;a second pulse shape; anda second pulse amplitude;wherein the first pulse frequency is different than the first microburst frequency;wherein the first pulse width is different than the second pulse width;wherein the first pulse shape is different than the second pulse shape; andwherein the first pulse amplitude is different than the second pulse amplitude; andwherein a microburst has a microburst characteristic where the microburst characteristic includes at least one of: a number of electrical pulses being between 2 to 25 and a microburst duration of 10 milliseconds to 1 second. 10. The implantable medical device of claim 9, wherein the first stimulation period and the second stimulation period are each a period of time. 11. The implantable medical device of claim 9, wherein the first stimulation period comprises a predetermined number of pulses. 12. The implantable medical device of claim 9, wherein the second stimulation period comprises a predetermined number of microbursts. 13. The implantable medical device of claim 9, wherein the first stimulation period and the second stimulation period overlap. 14. The implantable medical device of claim 9, further comprising a detection unit, wherein at least one of the first stimulation period and the second stimulation period is triggered based on the detection unit detecting a triggering event. 15. The implantable medical device of claim 9, wherein each microburst comprises between 2 and 15 microburst pulses and the first microburst duration is from 10 milliseconds to 80 milliseconds. 16. The implantable medical device of claim 9, wherein the cranial nerve is selected from: a vagus nerve;a trigeminal nerve; anda glossopharyngeal nerve.
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