[특허]Applicators for storing, sterilizing, and dispensing an adhesive

Adhezion Biomedical, LLC

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Applicators for storing, sterilizing, and dispensing an adhesive

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	B05C-017/005 B65D-035/36 B65D-051/22 A61B-017/00 A46B-011/00 A61M-035/00 A61F-013/40
출원번호	US-0726714 (2015-06-01)
등록번호	US-9533326 (2017-01-03)
발명자 / 주소	Ruiz, Sr., Rafael Zhang, Sheng Krauss, Martin
출원인 / 주소	Adhezion Biomedical, LLC
대리인 / 주소	Stradley Ronon Stevens & Young, LLP
인용정보	피인용 횟수 : 0 인용 특허 : 114

초록

Applicators for storing, sterilizing, and dispensing adhesives. The applicators comprise a porous tip, a body, and a container containing a polymerizable cyanoacrylate monomer adhesive. The applicators are sterilized by radiation, and following sterilization, the adhesive remains substantially unpolymerized for about twenty four months.

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1. An applicator for storing and dispensing an adhesive comprising: a) a container comprising walls defining a chamber, said walls comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, and a frangible seal covering a distal end of the chamber, said frangible seal having a side in communication with a stabilized cyanoacrylate monomer adhesive stored in the chamber;b) a body comprising a proximal end and a distal end, a flange comprising at least one hole, a channel in communication with the hole, said channel extending through the body, and having an opening at the distal end of the body, and a grip capable of constricting the channel when inward pressure is applied to the grip,wherein the proximal end of the flange is capable of penetrating the frangible seal when the body and the container are compressed together; andc) a porous tip in communication with the opening of the channel;wherein the applicator is activated by compressing the body and the container together whereupon the flange penetrates the frangible seal and allows the adhesive to flow into the hole, through the channel, and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 2. The applicator of claim 1, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 3. The applicator of claim 1, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 4. The applicator of claim 1, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 5. The applicator of claim 1, wherein the porous tip comprises a swab, sponge, foam, or a brush. 6. The applicator of claim 1, further comprising a tip overlay removably placed over top of the porous tip. 7. The applicator of claim 1, further comprising, a removable lock between the container and the body that prevents the body and the container from being compressed together and that, when removed, allows the body and the container to be compressed together. 8. An applicator for storing and dispensing an adhesive comprising: a) a flexible handle comprising a housing for a removable adhesive container, and a female end of a luer lock;b) a body comprising a male end of a luer lock capable of connecting to the female end of the luer lock, and a channel extending through the body and having an opening at an end;c) a porous tip in communication with the channel opening; andd) a removable adhesive container comprising a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, said container being capable of fitting within the housing, and further comprising a frangible seal covering an end of the container and having a side in communication with a stabilized cyanoacrylate monomer adhesive stored in the container;wherein the applicator is activated by compromising the frangible seal whereupon the adhesive may flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 9. The applicator of claim 8, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 10. The applicator of claim 8, wherein the container is a stick pack container. 11. The applicator of claim 8, wherein the frangible seal comprises aluminum foil laminated with a copolymer of acrylonitrile and methyl acrylate on the side in communication with the adhesive stored in the container. 12. The applicator of claim 8, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 13. The applicator of claim 8, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 14. The applicator of claim 8, wherein the porous tip comprises a swab, sponge, foam, or a brush. 15. The applicator of claim 8, further comprising a tip overlay removably placed over top of the porous tip. 16. An applicator for storing and dispensing an adhesive comprising: a) a container comprising walls and an opening, said walls comprising screw threads on the exterior, and a single layer of a copolymer of acrylonitrile and methyl acrylate or comprising multiple layers with the inner-most layer comprising a copolymer of acrylonitrile and methyl acrylate, a frangible seal covering the opening, said container containing a stabilized cyanoacrylate monomer adhesive;b) a body comprising a cavity, a channel in communication with the cavity, said channel extending through the body and having an opening at an end, a grip capable of constricting the channel when inward pressure is applied to the grip, at least one projection in the cavity, wherein the projection is capable of penetrating the frangible seal when the body and the container are compressed together, and screw threads on the inner walls of the cavity for engaging the screw threads on the exterior of the walls of the container; andc) a porous tip in communication with the opening of the channel; wherein the applicator is activated by screwing the body and the container together whereupon the projection penetrates the frangible seal and allows the adhesive to flow into and through the channel and out of the porous tip, and wherein at least the container is sterilized by radiation, and the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twelve months of shelf storage thereafter. 17. The applicator of claim 16, wherein the cyanoacrylate monomer comprises a monomer of 2-octyl cyanoacrylate, dodecyl cyanoacrylate, 2-ethylhexyl cyanoacrylate, butyl cyanoacrylate, methyl cyanoacrylate, 3-methoxybutyl cyanoacrylate, 2-butoxyethyl cyanoacrylate, 2-isopropoxyethyl cyanoacrylate, 1-methoxy-2-propyl cyanoacrylate, or a combination thereof. 18. The applicator of claim 16, wherein the frangible seal comprises aluminum foil laminated with a copolymer of acrylonitrile and methyl acrylate on the side in communication with the chamber. 19. The applicator of claim 16, wherein the radiation is gamma radiation, electron beam radiation, or x-ray radiation. 20. The applicator of claim 16, wherein the adhesive stored in the chamber of the container does not cure upon radiation exposure and for at least about twenty four months of shelf storage thereafter. 21. The applicator of claim 16, wherein the porous tip comprises a swab, sponge, foam, or a brush. 22. The applicator of claim 16, further comprising a tip overlay removably placed over top of the porous tip. 23. The applicator of claim 16, further comprising, a removable lock between the container and the body that prevents the body and the container from being screwed together and that, when removed, allows the body and the container to be screwed together.

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Applicators for storing, sterilizing, and dispensing an adhesive

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Applicators for storing, sterilizing, and dispensing an adhesive

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