초록 ▼

Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag

Delivering a blood processing solution to blood in a blood bag includes coupling a first tube to a vented spike at one end and to a Y-shaped tube connector at a second end. An in-line microbiotic barrier filter is coupled to the first tube between its ends. A second tube is coupled to a transfer bag at one end and to the Y-shaped tube connector at its other end. A third tube is coupled to the output of the Y-shaped tube connector and sealed at its distal end. The blood bag includes a fourth tube that is sealed at a distal end. The third tube is welded to the fourth tube using a sterile tubing welder, wherein a functionally-closed, sterile flow path through which the blood processing solution can flow into the blood bag is maintained.

대표청구항 ▼

1. A functionally-closed, sterile Y-type tube set comprising: a vented spike coupled to a first end of a first tube;a Y-shaped tube connector having a first and a second input and an output, wherein a second end of the first tube is coupled to the first input of the Y-shaped tube connector;an in-lin

1. A functionally-closed, sterile Y-type tube set comprising: a vented spike coupled to a first end of a first tube;a Y-shaped tube connector having a first and a second input and an output, wherein a second end of the first tube is coupled to the first input of the Y-shaped tube connector;an in-line microbiotic barrier filter coupled between the first and second ends of the first tube, wherein a flow path extends from the first end to the second end of the first tube that passes through the microbiotic barrier filter;a transfer bag coupled to a first end of a second tube, wherein a second end of the second tube is coupled to the second input of the Y-shaped tube connector; anda third tube coupled to the output of the Y-shaped tube connector, wherein a second end of the third tube is sealed. 2. The functionally-closed, sterile Y-type tube set of claim 1, wherein the inline microbiotic filter is a 0.2 micron IV filter. 3. The Y-type tube set of claim 1, wherein the transfer bag is empty. 4. The Y-type tube set of claim 1, wherein the transfer bag includes a wash solution. 5. A method for delivering a blood processing solution to a blood component present in a blood bag, the method comprising: obtaining a functionally-closed sterile tube set comprising i) Y-type tube connector, (ii) a first tube providing a flow path extending from a vented spike at a first end of the first tube through an inline microbiotic filter to a second end of the first tube, the second end coupled to a first input of the Y-type tube connector, (iii) a transfer bag coupled to a second input of the Y-type tube connector, and (iv) a sealed output tube coupled to an output of the Y-type tube connector;welding the sealed output tube to a sealed input tubing of a blood bag using a sterile tubing welder, wherein a functionally-closed, sterile flow path is maintained through which a blood processing solution can flow into the blood bag; andinserting the vented spike into avid containing the blood processing solution to deliver the blood processing solution through the inline microbiotic filter and into a blood component in the blood bag. 6. The method of claim 5, further comprising storing the treated blood component greater than 24 hours for use thereafter. 7. The method of claim 5, wherein the in-line microbiotic barrier filter is a 0.2 micron IV filter. 8. The method of claim 5, further comprising increasing the intracellular content of ATP and 2,3-DPG of the blood component as a result of delivering the blood processing solution to the blood component. 9. The method of claim 5, wherein blood component comprises a red blood cell concentrate, the method further comprising increasing the intracellular content of adenosine triphosphate and 2,3-diphosphoglycerate of the red blood cell concentrate as a result of delivering the blood processing solution to the red blood cell concentrate. 10. The method of claim 5, further comprising processing the blood and blood processing solution together using a functionally-closed, sterile cell processor. 11. The method of claim 5, further comprising processing the blood and blood processing solution together using a functionally-closed, sterile centrifuge. 12. A blood processing system, comprising: a Y-shaped tube connector having a first input, a second input, and an output;a first tube comprising an in-line filter, the first tube coupled to the first input;a transfer bag coupled to the second input; andan output tube coupled to the output of the Y-shaped tube connector, the output tube having a sealed end;a vented spike configured to be coupled to the first tube; anda container comprising a blood processing composition, the container configured to be pierced by the vented spike. 13. The blood processing system of claim 12, wherein the transfer bag is empty. 14. The blood processing system of claim 12, wherein the transfer bag includes a wash solution configured to wash a blood product. 15. The blood processing system of claim 12, wherein the blood processing composition comprises inosine, pyruvate, adenine, and a phosphate mixture. 16. The blood processing system of claim 15, wherein the blood processing composition comprises between about 2 to 30 g/L inosine, between about 5 to 15 g/L pyruvate, between about 0.2 to 2 g/L adenine, and between about 10 to 30 g/L phosphate. 17. The blood processing system of claim 15, wherein the blood processing system is packaged in a single container. 18. The blood processing system of claim 17, wherein the container includes instructions for use of the blood processing system. 19. The blood processing system of claim 12, wherein the in-line filter is a 0.2 micron filter. 20. The blood processing system of claim 12, wherein the transfer bag is coupled to second input through a tube.