An applicator for providing HIFU therapy to a patient includes a HIFU transducer that is rotatably coupled to a frame. In one embodiment, the rotatable coupling is configured such that the HIFU transducer can be mechanically oriented to position a focal zone of the HIFU transducer at any desired loc
An applicator for providing HIFU therapy to a patient includes a HIFU transducer that is rotatably coupled to a frame. In one embodiment, the rotatable coupling is configured such that the HIFU transducer can be mechanically oriented to position a focal zone of the HIFU transducer at any desired location in a treatment volume radially outward from a longitudinal axis of the applicator while the HIFU transducer remains within a housing that is not more than a defined percentage (e.g., 50%) larger than the maximum diameter of the HIFU transducer. In one embodiment, the HIFU transducer is rotatably coupled to the frame with a ball and socket joint. In another embodiment, the HIFU transducer is rotatably coupled to the frame with an offset gimble assembly. A pair of linear actuators and drive shafts engage the HIFU transducer to orient HIFU transducer in a desired direction.
대표청구항▼
1. A HIFU applicator configured to deliver high intensity focused ultrasound (HIFU) signals to a treatment volume, comprising: a frame;a HIFU transducer movably coupled to the frame and configured to deliver HIFU treatment signals to a focal zone;a mechanism configured to mechanically orient the HIF
1. A HIFU applicator configured to deliver high intensity focused ultrasound (HIFU) signals to a treatment volume, comprising: a frame;a HIFU transducer movably coupled to the frame and configured to deliver HIFU treatment signals to a focal zone;a mechanism configured to mechanically orient the HIFU transducer with respect to the frame such that the focal zone of the HIFU transducer can be positioned radially outward from a longitudinal axis of the HIFU applicator, wherein the mechanism includes a plurality of movable drive shafts, each drive shaft being connected to a linkage that couples the HIFU transducer to the drive shaft, and wherein at least one of the linkages coupling the HIFU transducer to a drive shaft is not axially aligned with the longitudinal axis of the HIFU applicator; anda housing surrounding the HIFU transducer, wherein the HIFU transducer has a maximum diameter in a transverse plane defined across the HIFU transducer, and wherein the housing has an inner diameter that is not more than 50% larger than the maximum diameter of the HIFU transducer,wherein the mechanism configured to mechanically orient the HIFU transducer provides the HIFU transducer with a center of rotation that is located substantially at the transverse plane of the HIFU transducer, andwherein, when the HIFU transducer is oriented in a centered position in which the transverse plane of the HIFU transducer is perpendicular to the longitudinal axis of the HIFU applicator, the focal zone of the HIFU transducer is positioned within the treatment volume approximately inline with the longitudinal axis of the HIFU applicator. 2. The HIFU applicator of claim 1, further comprising a mechanism configured to selectively raise and lower the HIFU transducer to vertically position the focal zone of the HIFU transducer with respect to the frame. 3. The HIFU applicator of claim 1, wherein the mechanism configured to mechanically orient the HIFU transducer comprises a joint having rotatable ball and socket, wherein the ball is connected to one of the frame or the HIFU transducer and the socket is connected to the other of the frame or the HIFU transducer. 4. The HIFU applicator of claim 3, wherein the plurality of drive shafts engage the HIFU transducer via the linkages to selectively move the ball with respect to the socket. 5. The HIFU applicator of claim 3, wherein the ball and socket joint rotatably couples the HIFU transducer to the frame such that the HIFU transducer can be physically tilted to position the focal zone in a direction radially outward from the longitudinal axis of the HIFU applicator; and wherein the ball and socket joint provides the HIFU transducer with a center of rotation that is located with respect to the maximum diameter of the HIFU transducer such that the focal zone of the HIFU transducer can be radially oriented up to 4 cm away from the longitudinal axis of the HIFU applicator at a depth of at least 10 cm while the housing surrounding the HIFU transducer has an internal diameter that is not more than 10% larger than the maximum diameter of the HIFU transducer. 6. The HIFU applicator of claim 1, wherein the mechanism configured to mechanically orient the HIFU transducer comprises a single sided offset gimble assembly that couples the HIFU transducer to the frame and allows the focal zone of the HIFU transducer to be positioned radially outward from the longitudinal axis of the HIFU applicator, wherein the single sided offset gimble assembly includes an offset gimble pivoting mount arm that is rotatably affixed by a pivot link to an offset gimble swing arm, and the offset gimble swing arm is rotatably affixed by a pivot link to the HIFU transducer. 7. The HIFU applicator of claim 6, wherein the plurality of drive shafts engage the HIFU transducer via the linkages to move the HIFU transducer relative to the frame within constraints of the single sided offset gimble assembly and orient the HIFU transducer at an angular position relative to the longitudinal axis of the HIFU applicator. 8. The HIFU applicator of claim 7, wherein the linkages are drive linkages that dynamically adjust the combined effective length of the respective drive shaft and the drive linkage to linearize the relationship between a translation distance of the drive shaft and the angular position of the HIFU transducer. 9. The HIFU applicator of claim 1, wherein the HIFU transducer has a central aperture and the applicator includes an imaging transducer positioned within the central aperture. 10. The HIFU applicator of claim 9, wherein the mechanism configured to mechanically orient the HIFU transducer is configured to physically move the HIFU transducer relative to the imaging transducer in order to change the radial position of the focal zone in the treatment volume. 11. The HIFU applicator of claim 1, wherein the mechanism configured to mechanically orient the HIFU transducer with respect to the frame is configured such that the focal zone of the HIFU transducer can be positioned at least 1.0 cm radially outward from the longitudinal axis of the applicator. 12. The HIFU applicator of claim 1, wherein the mechanism configured to mechanically orient the HIFU transducer with respect to the frame is configured such that the focal zone of the HIFU transducer can be positioned at least 2.0 cm radially outward from the longitudinal axis of the applicator. 13. The HIFU applicator of claim 1, wherein the inner diameter of the housing is not more than 30% larger than the maximum diameter of the HIFU transducer. 14. The HIFU applicator of claim 1, wherein the inner diameter of the housing is not more than 15% larger than the maximum diameter of the HIFU transducer. 15. The HIFU applicator of claim 1, wherein the inner diameter of the housing is not more than 10% larger than the maximum diameter of the HIFU transducer. 16. The HIFU applicator of claim 1, wherein the mechanism for mechanically orienting the HIFU transducer is configured such that the focal zone of the HIFU transducer can be positioned over an angle that is at least 5 degrees radially outward from the longitudinal axis of the applicator. 17. The HIFU applicator of claim 1, wherein the mechanism for mechanically orienting the HIFU transducer is configured such that the focal zone of the HIFU transducer can be positioned over an angle that is at least 10 degrees radially outward from the longitudinal axis of the applicator. 18. The HIFU applicator of claim 1, wherein the mechanism for mechanically orienting the HIFU transducer is configured such that the focal zone of the HIFU transducer can be positioned over an angle that is at least 15 degrees radially outward from the longitudinal axis of the applicator. 19. The HIFU applicator of claim 1, wherein the frame includes a main tube that is configured to translate vertically toward and away from the treatment volume and the housing surrounding the HIFU transducer includes fluid, wherein a volume of the fluid within the housing changes as the main tube vertically translates, and wherein the HIFU applicator further comprises a fluid volume compensation system that is configured to mechanically maintain a constant fluid volume for the HIFU applicator, the fluid volume compensation system including one or more cylinders, each cylinder having a hydraulic piston disposed therein that is coupled to the main tube in an inverse relationship such that as the main tube translates downward, the hydraulic pistons translate upward, providing portions of the one or more cylinders that fill with fluid and adjust for most if not all of the fluid volume change in the housing resulting from translation of the main tube. 20. The HIFU applicator of claim 19, further comprising one or more actuators that are coupled to corresponding drive shafts of the hydraulic pistons, wherein the one or more actuators are configured to adjust the position of the hydraulic pistons within their respective cylinders to maintain a constant combined fluid volume in the housing and the fluid-filled portions of the one or more cylinders. 21. The HIFU applicator of claim 1, wherein the housing surrounding the HIFU transducer is cylindrical. 22. A HIFU applicator configured to deliver high intensity focused ultrasound (HIFU) signals to a treatment volume, comprising: a frame;a HIFU transducer movably coupled to the frame and configured to deliver HIFU treatment signals to a focal zone, wherein the HIFU transducer has a transverse axis defined transversely across the HIFU transducer; anda mechanism configured to mechanically orient the HIFU transducer with respect to the frame such that the focal zone of the HIFU transducer can be positioned radially outward from a longitudinal axis of the HIFU applicator,wherein the mechanism provides the HIFU transducer with a center of rotation that is located away from an inner surface of the HIFU transducer within a volume surrounded by the HIFU transducer, andwherein, when the HIFU transducer is oriented in a centered position in which the transverse axis of the HIFU transducer is perpendicular to the longitudinal axis of the HIFU applicator, the focal zone of the HIFU transducer is positioned within the treatment volume approximately inline with the longitudinal axis of the HIFU applicator. 23. A HIFU applicator configured to deliver high intensity focused ultrasound (HIFU) signals to a treatment volume, comprising: a frame;a HIFU transducer movably coupled to the frame and configured to deliver HIFU treatment signals to a focal zone; anda mechanism configured to mechanically orient the HIFU transducer with respect to the frame such that the focal zone of the HIFU transducer can be positioned radially outward from a longitudinal axis of the HIFU applicator,wherein the mechanism provides the HIFU transducer with a center of rotation that is located substantially at a plane defined transversely across the HIFU transducer at a maximum diameter of the HIFU transducer, andwherein, when the HIFU transducer is oriented in a centered position in which the plane defined transversely across the HIFU transducer is perpendicular to the longitudinal axis of the HIFU applicator, the HIFU transducer is positioned to deliver the HIFU treatment signals to the focal zone approximately inline with the longitudinal axis of the HIFU applicator. 24. A HIFU applicator configured to deliver high intensity focused ultrasound (HIFU) signals to a treatment volume, comprising: a frame;a HIFU transducer movably coupled to the frame and configured to deliver HIFU treatment signals to a focal zone;a mechanism configured to mechanically orient the HIFU transducer with respect to the frame such that the focal zone of the HIFU transducer can be positioned radially outward from a longitudinal axis of the HIFU applicator, wherein the mechanism includes a plurality of movable drive shafts, each drive shaft being connected to a linkage that couples the HIFU transducer to the drive shaft, and wherein at least one of the linkages coupling the HIFU transducer to a drive shaft is not axially aligned with the longitudinal axis of the HIFU applicator; anda housing surrounding the HIFU transducer, wherein the housing has an inner diameter that is not more than 50% larger than a maximum diameter of the HIFU transducer,wherein the mechanism configured to mechanically orient the HIFU transducer comprises a single sided offset gimble assembly that couples the HIFU transducer to the frame and allows the focal zone of the HIFU transducer to be positioned radially outward from the longitudinal axis of the HIFU applicator, wherein the single sided offset gimble assembly includes an offset gimble pivoting mount arm that is rotatably affixed by a pivot link to an offset gimble swing arm, and the offset gimble swing arm is rotatably affixed by a pivot link to the HIFU transducer. 25. The HIFU applicator of claim 24, wherein the plurality of drive shafts engage the HIFU transducer via the linkages to move the HIFU transducer relative to the frame within constraints of the single sided offset gimble assembly and orient the HIFU transducer at an angular position relative to the longitudinal axis of the HIFU applicator. 26. The HIFU applicator of claim 25, wherein the linkages are drive linkages that dynamically adjust the combined effective length of the respective drive shaft and the drive linkage to linearize the relationship between a translation distance of the drive shaft and the angular position of the HIFU transducer.
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