Compositions for inhibition of insect sensing
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A01N-043/653
A01N-043/78
A01N-043/90
A01N-043/82
A01N-027/00
A01N-029/02
A01N-033/22
A01N-053/00
출원번호
US-0115553
(2012-04-25)
등록번호
US-9578881
(2017-02-28)
국제출원번호
PCT/US2012/034847
(2012-04-25)
§371/§102 date
20140502
(20140502)
국제공개번호
WO2012/154403
(2012-11-15)
발명자
/ 주소
Zwiebel, Laurence
Pask, Gregory M.
Rinker, David C.
Romaine, Ian M.
Sulikowski, Gary A.
Reid, Paul R.
Waterson, Alex G.
Kim, Kwangho
Jones, Patrick L.
Taylor, Robert W.
출원인 / 주소
Vanderbilt University
대리인 / 주소
Ballard Spahr LLP
인용정보
피인용 횟수 :
2인용 특허 :
28
초록▼
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporati
In one aspect, the invention relates to chemical modulators of insect olfactory receptors. In particular, compounds and compositions are provided that can inhibit sensory (e.g., host targeting) functions in airborne insects such as mosquitos. Method of employing such agents, and articles incorporating the same, are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
대표청구항▼
1. A method comprising delivering to an insect a compound, or a salt thereof, represented by the formula: wherein R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken t
1. A method comprising delivering to an insect a compound, or a salt thereof, represented by the formula: wherein R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl, or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; andR5 is optionally substituted aryl or optionally substituted (≦C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,wherein the compound is not 2. The method of claim 1, wherein the compound is delivered to the insect as a pest-control composition, as a topical formulation, or as a pest-control article. 3. The method of claim 1, wherein R1, R2, and R6 are hydrogen; wherein R3 is halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl; wherein R4 is (C1-C5) alkyl; and wherein R5 is optionally substituted (≦C6) heteroaryl. 4. The method of claim 1, wherein the compound is selected from: 5. The method of claim 1, the method further comprising delivering to the insect an insect-control composition comprising at least one delivery agent and the compound, or a salt thereof. 6. The method of claim 5, wherein the delivery agent comprises a water-soluble tablet, an aerosol, a sprayable liquid, a misting system, bait, lotion, or a pellet. 7. The method of claim 5, wherein the delivery agent comprises at least one volatile organic compound. 8. The method of claim 7, wherein the at least one volatile organic compound is selected from chlorpyrifos, 1,3-dichloropropene, trifuralin, methyl bromide, demthoate, metam-sodium, oxyfluorfen, permethrin, limonene, chloropicrin, bifenthrin, and bensulide. 9. The method of claim 1, the method further comprising delivering to the insect a topical formulation comprising the compound, or a salt thereof, and at least one agent selected from film forming agents, ester containing solvents, gelling agents, skin conditioning agents and emollients, antioxidants, structuring agents, emulsifiers, silicone containing compounds, essential oils, thickening agents, and vehicles. 10. The method of claim 1, the method further comprising delivering to the insect an insect-control article comprising the compound, or a salt thereof, coated onto or impregnated into an article selected from netting, clothing, fabric, bedding, tarps, tents, awnings, door flaps, screens, and drapes. 11. The method of claim 1, wherein the compound is represented by the formula: wherein R1 is hydrogen or optionally substituted C1-C4 alkyl; wherein R2 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl; wherein R4 is optionally substituted (C1-C5) alkyl; wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 12. The method of claim 11, wherein R1 is hydrogen; wherein R2 is hydrogen; wherein R3 is methyl, ethyl, n-propyl, or isopropyl; wherein R4 is ethyl, propyl, or cyclopropyl; and wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, or —NO2. 13. The method of claim 1, wherein the compound is represented by the formula: wherein R11 is —H, —OH, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 14. The method of claim 13, wherein R1 is hydrogen; wherein R2 is hydrogen; wherein R3 is methyl, ethyl, n-propyl, or isopropyl; and wherein R11 is hydrogen, hydroxy, —F, —CI, —Br, —I, —NH2, or —NO2. 15. The method of claim 1, wherein the compound is represented by the formula: wherein R11 is —H, —OH, —F, —CI, —Br, —I, —NH2, —NO2, —CO2H, —CO2CH3, —CN, —SH, —OCH3, —OCH2CH3, —C(O)CH3, —N(CH3)2, —C(O)NH2, —OC(O)CH3, or —S(O)2NH2. 16. The method of claim 15, wherein the compound is represented by the formula: 17. The method of claim 16, wherein R1 is hydrogen; wherein R2 is hydrogen; and wherein R3 is methyl, ethyl, n-propyl, or isopropyl. 18. The method of claim 1, wherein the compounds is selected from: 19. The method of claim 1, wherein the insect is a mosquito. 20. A method comprising providing to an insect environment a compound, or a salt thereof, represented by the formula: wherein R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl, or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; andR5 is optionally substituted aryl or optionally substituted (≦C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,wherein the compound is not wherein the insect environment is selected from selected from single-family dwelling, yard, street, neighborhood, subdivision, township, city, agricultural environment, potential host, insect nest, domestic animal, plant, livestock, and human. 21. A method comprising providing to an insect environment a compound, or a salt thereof, represented by the formula: wherein R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from: or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR2 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl, or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; andR3 is hydrogen, hydroxy, nitro, halo, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl; andR4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; andR5 is optionally substituted aryl or optionally substituted (≦C6) heteroaryl; andR6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,wherein the compound is not wherein the compound is provided to the insect environment via a delivery system selected from water-soluble tablet, an aerosol, a sprayable liquid, a misting system, bait, lotion, pellet, volatile organic compound, topical formulation, insect-control article, clothing, fabric, and bedding.
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