Systems and methods for thermophotonic dynamic imaging
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-021/71
H04N-007/18
A61B-005/00
출원번호
US-0522936
(2012-01-20)
등록번호
US-9584771
(2017-02-28)
국제출원번호
PCT/CA2012/050035
(2012-01-20)
§371/§102 date
20131216
(20131216)
국제공개번호
WO2012/135952
(2012-10-11)
발명자
/ 주소
Mandelis, Andreas
Tabatabaei, Nima
Abrams, Stephen
출원인 / 주소
Mandelis, Andreas
대리인 / 주소
Schumacher, Lynn C.
인용정보
피인용 횟수 :
3인용 특허 :
3
초록▼
Systems and methods for improved thermophotonic imaging are provided in which both amplitude and phase image information is obtained with a high signal to noise ratio and depth-resolved capabilities. Image data obtained from an imaging camera is dynamically averaged and subsequently processed to ext
Systems and methods for improved thermophotonic imaging are provided in which both amplitude and phase image information is obtained with a high signal to noise ratio and depth-resolved capabilities. Image data obtained from an imaging camera is dynamically averaged and subsequently processed to extract amplitude and/or phase image data. The system may be configured for a wide range of imaging modalities, including single frequency modulation (thermophotonic lock-in imaging), Thermal-Wave Radar imaging or Thermophotonic Radar imaging involving chirp modulation, and Binary Phase Coded Modulation. Such imaging modalities may find application in many diverse areas, including non-destructive testing and biomedical diagnostic imaging including the imaging of teeth and monitoring changes in the tooth over time which are due to pathology such as dental caries or erosion.
대표청구항▼
1. A method of performing thermophotonic imaging, said method comprising the steps of: providing a sample;providing an optical source having a wavelength selected to generate photothermal radiation within said sample;providing an imaging camera with an optical bandwidth selected for detection of sai
1. A method of performing thermophotonic imaging, said method comprising the steps of: providing a sample;providing an optical source having a wavelength selected to generate photothermal radiation within said sample;providing an imaging camera with an optical bandwidth selected for detection of said photothermal radiation;generating a reference waveform comprising a plurality of modulation cycles, wherein said reference waveform comprises multiple frequency components;producing a modulated optical beam by modulating an intensity of an optical beam emitted by said optical source according to said reference waveform;illuminating said sample with said modulated optical beam;imaging said photothermal radiation with said imaging camera;recording a plurality of averaged image frames at time offsets corresponding to different values of said reference waveform; andprocessing said averaged image frames and said reference waveform to obtain an image relating to said photothermal radiation, wherein said image is a cross-correlation image obtained by calculating a complex cross-correlation of said reference waveform and each pixel of said averaged image frames, thereby obtaining a complex cross-correlation signal for each pixel, and processing the complex cross-correlation signals to obtain the cross-correlation image;wherein said cross-correlation image is one of: (i) a cross-correlation peak amplitude image obtained by determining, for each said pixel, a peak amplitude value of a peak in a real part of said cross-correlation signal;(ii) a cross-correlation peak delay image obtained by determining, for each said pixel, a delay of a peak in a real part of said complex cross-correlation signal; and(iii) a cross-correlation phase image obtained by the steps of: obtaining a second complex cross-correlation signal of a quadrature waveform and each pixel of said averaged image frames, wherein said quadrature waveform is based on said reference waveform;forming a complex quantity comprising a real portion of first complex cross-correlation signal and a real portion of said second complex cross-correlation signal; andobtaining said phase image by determining, for each pixel, a phase angle of said complex quantity at a pre-selected time delay. 2. The method according to claim 1 wherein said dynamically averaged image frames are obtained according to the following steps: recording a plurality of image frames at times corresponding to different values of said reference waveform;repeating, one or more times, said step of recording said image frames at times corresponding to different values of said reference waveform, and dynamically averaging said recorded image frames for each said different value of said reference waveform, thereby obtaining dynamically averaged image frames. 3. The method according to claim 2 wherein said step of recording said plurality of image frames at different values of said reference waveform comprises recording said plurality of image frames over a single modulation cycle/correlation period. 4. The method according to claim 2 wherein said plurality of image frames at different values of said reference waveform are obtained over more than one modulation cycle. 5. The method according to claim 4 wherein a frame acquisition rate of said imaging camera is less than a modulation frequency of said reference waveform. 6. The method according to claim 2 further comprising the step of recording, for each image frame of said plurality of image frames, a substantially instantaneous value of said reference waveform. 7. The method according to claim 6 further comprising the step of generating a quadrature waveform based on said reference waveform, and recording, for each image frame of said plurality of image frames, a substantially instantaneous value of said quadrature waveform. 8. The method according to claim 1 further comprising the step of generating an integration pulse train comprising a series of pulses, wherein each pulse is generated at a time at which an image frame is acquired by said imaging camera, wherein said step of generating of said reference waveform is triggered according to said integration pulse train. 9. The method according to claim 8 wherein said integration pulse train is generated by said imaging camera. 10. The method according to claim 1 further comprising the step of generating a flag pulse train comprising a series of pulses, wherein each pulse is generated at a commencement of a given modulation cycle/correlation period, and identifying one or both of a beginning and an end of said given modulation cycle/correlation period according to said flag pulse train. 11. The method according to claim 1 wherein a modulation frequency of said reference waveform is greater than approximately 0.01 Hz. 12. The method according to claim 1 wherein said reference waveform comprises a single frequency and wherein said image is obtained by lock-in processing. 13. The method according to claim 12 wherein said step of processing said dynamically averaged image frames and said reference waveform comprises, for each pixel in said image, performing the steps of: multiplying said dynamically averaged image frames by said reference waveform to obtain in-phase product values; andsumming said in-phase product values to obtain an in-phase sum;generating a quadrature waveform based on said reference waveform;multiplying said dynamically averaged image frames by said quadrature waveform to obtain phase-shifted product values; andsumming said phase-shifted product values to obtain a phase-shifted sum. 14. The method according to claim 13 wherein said image is an amplitude image, and wherein said processing further comprises calculating a magnitude of a complex quantity based on said in-phase sum and said phase-shifted sum. 15. The method according to claim 13 wherein said image is a phase image, and wherein said processing further comprises: calculating a phase angle of a complex quantity based on said in-phase sum and said phase-shifted sum. 16. The method according to claim 1, wherein said reference waveform comprises a frequency chirp. 17. The method according to claim 1, wherein said reference waveform is a binary phase coded waveform. 18. The method according to claim 1 wherein said sample is selected from the group consisting of automotive components, aerospace components, an optical material, a laser material, a biomedical material, and a biological tissue. 19. The method according to claim 1 wherein said sample is a material comprising one or more of a subsurface crack and a delamination. 20. The method according to claim 1 wherein said sample is an unsintered component in a green state. 21. The method according to claim 1 further comprising the step of determining a case hardness depth. 22. The method according to claim 1 wherein said sample is a dental sample, the method including the step of displaying the image. 23. The method according to claim 1 wherein said sample is a dental or medical instrument. 24. The method according to claim 1 wherein said sample includes bone, wherein the step of imaging the photothermal radiation with the imaging camera includes imaging photothermal radiation generated within the bone. 25. The method according to claim 24 wherein the bone is covered with tissue, and wherein the optical source is configured for transmitting at least a portion of the optical beam through the tissue for the generation of the photothermal radiation within the bone. 26. The method according to claim 24 further wherein a modulation frequency of the modulated optical beam is selected to support penetration of the photothermal radiation within a trabecular structure of the bone. 27. The method according to claim 24 further including the step of identifying an onset or presence of osteoporosis in the bone based on the image. 28. The method according to claim 22 further wherein said dental sample is a tooth sample or whole groups of teeth. 29. The method according to claim 22 wherein the dental sample is a tooth, the method further comprising the step of analyzing said image to determine one or more of a presence and a location of demineralization, erosion or dental caries in said tooth. 30. The method according to claim 22 further comprising the step of monitoring an evolution of one or more of demineralization, erosion and dental caries by comparing said image to one or more other images. 31. The method according to claim 22 wherein the image is a first image, the method further comprising the step of obtaining additional image of the dental sample after a time delay, and comparing the first image to the additional image for monitoring changes in the dental sample. 32. The method according to claim 22 wherein the image is a first image, the method further comprising the step of applying a treatment or therapy to said dental sample, obtaining additional image, and comparing the first image to the additional image to assess an efficacy of the treatment or therapy. 33. The method according to claim 22 wherein the dental sample is a tooth surface that is prepared for prepared for placement of a direct or indirect restoration, the method including the step of confirming, based on the image, suitability of the tooth surface for placement of the restoration. 34. The method according to claim 22 wherein the dental sample includes a tooth having a dental material placed directly thereon, wherein the image includes a region around an edge of the dental material for detecting or monitoring a defect around the edge of the dental material. 35. The method according to claim 34 wherein the dental material is a dental sealant. 36. The method according to claim 22 wherein the dental sample includes a tooth having a dental prosthetic, wherein the image includes the dental prosthetic for detecting or monitoring a defect associated with the dental prosthetic. 37. The method according to claim 22 wherein the dental sample includes a tooth having a dental restoration attached thereto, wherein the image includes the dental restoration for detecting or monitoring the attachment of the dental restoration. 38. The method according to claim 22 wherein the dental sample includes a dental implant, wherein the image includes the dental implant for detecting or monitoring the integrity of the dental implant. 39. The method according to claim 22 wherein the image includes at least one of a pulp chamber and root canal system of the dental sample. 40. The method according to claim 22 wherein the image includes an anatomical structure of root apices or the neurovascular bundle. 41. The method according to claim 1 further comprising the step of identifying a defect region in the image. 42. The method according to claim 41 further comprising the step of displaying the defect region in a color associated with the defect region. 43. The method according to claim 42 wherein the color is associated with a relative size of the defect region. 44. The method according to claim 23 wherein said dental or medical instrument is selected from the group consisting of endodontic instruments, catheters and other indwelling instruments. 45. The method according to claim 1 wherein said wavelength is selected to lie within a range of approximately 600 nm to 2000 nm. 46. The method according to claim 1 wherein said imaging camera is selected to have a spectral response overlapping with at least a portion of the mid-infrared spectrum. 47. A method of performing thermophotonic imaging, said method comprising the steps of: providing a sample;providing an optical source having a wavelength selected to generate photothermal radiation within said sample;providing an imaging camera with an optical bandwidth selected for detection of said photothermal radiation;generating a reference waveform comprising a binary phase coded waveform having a plurality of modulation cycles, wherein said reference waveform comprises multiple frequency components;producing a modulated optical beam by modulating an intensity of an optical beam emitted by said optical source according to said reference waveform;illuminating said sample with said modulated optical beam;imaging said photothermal radiation with said imaging camera;recording a plurality of averaged image frames at time offsets corresponding to different values of said reference waveform; and processing said averaged image frames and said reference waveform to obtain an image relating to said photothermal radiation, wherein said image is a cross-correlation image obtained by calculating a complex cross-correlation of said reference waveform and each pixel of said averaged image frames, thereby obtaining a complex cross-correlation signal for each pixel, and processing the complex cross-correlation signals to obtain the cross-correlation image;wherein said cross-correlation image is one of: (i) a cross-correlation peak amplitude image obtained by determining, for each said pixel, a peak amplitude value of a peak in a real part of said cross-correlation signal;(ii) a cross-correlation peak delay image obtained by determining, for each said pixel, a delay of a peak in a real part of said complex cross-correlation signal; and(iii) a cross-correlation phase image obtained by the steps of: obtaining a second complex cross-correlation signal of a quadrature waveform and each pixel of said averaged image frames, wherein said quadrature waveform is based on said reference waveform;forming a complex quantity comprising a real portion of first complex cross-correlation signal and a real portion of said second complex cross-correlation signal; andobtaining said phase image by determining, for each pixel, a phase angle of said complex quantity at a pre-selected time delay.
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이 특허에 인용된 특허 (3)
Enachescu, Marian; Belikov, Sergey, Data structures and algorithms for precise defect location by analyzing artifacts.
Elbaum Marek ; Greenebaum Michael ; Jacobs Adam ; Keem Sunguk ; Schneiderman Allen H. ; Shultz Theodore S., Method and apparatus for electronically imaging a tooth through transillumination by light.
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