초록 ▼

Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The formulations can include gels or hydrogels that contain at least one reactive oxygen species (ROS). The formulations can include a composition co

Formulations containing reactive oxygen species (ROS), processes for making these formulations, and methods of using these formulations are described. The formulations can include gels or hydrogels that contain at least one reactive oxygen species (ROS). The formulations can include a composition containing a reduced species (RS) and a reactive oxygen species (ROS). The formulations can also contain a rheology modifier and can include gels or hydrogels. Methods of preparing the formulations can include preparing a composition. Compositions can be prepared by providing water, purifying the water to produce ultra-pure water, combining sodium chloride to the ultra-pure water to create salinated water, and electrolyzing the salinated water at a temperature between about 4.5 to about 5.8° C.

대표청구항 ▼

1. A method of preparing a composition, comprising: purifying water at a temperature between about 15 and 20° C. to produce an ultra-pure water;combining salt to the ultra-pure water to create a salinated water, wherein the salt comprises sodium chloride;circulating the salinated water for more than

1. A method of preparing a composition, comprising: purifying water at a temperature between about 15 and 20° C. to produce an ultra-pure water;combining salt to the ultra-pure water to create a salinated water, wherein the salt comprises sodium chloride;circulating the salinated water for more than 72 hours at room temperature;cooling the salinated water to a temperature of about 4.5 to about 5.8° C.;electrolyzing the salinated water at a temperature of about 4.5 to about 5.8° C.; andcombining a rheology modifier, wherein the electrolyzing is accomplished with an anode, a cathode and a power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor. 2. The method of claim 1, wherein the method includes a pulsating voltage such that the voltage is about zero at least about 50 times per second. 3. The method of claim 1, further comprising combining the composition with a buffering agent. 4. The method of claim 1, wherein the rheology modifier further comprises SiO2, MgO, Li2O, Na2O, a cross-linked acrylic acid polymer, poly(acrylic acid), or combinations thereof. 5. The method of claim 1, further comprising: sodium present at a concentration of about 1000 to about 1400 ppm, as measured by inductively coupled plasma mass spectrometry (ICP-MS);chloride present at a concentration from about 1200 to about 1600 ppm, as measured by inductively coupled plasma mass spectrometry (ICP-MS)hypochlorous acid present at a concentration of about 16 to about 24 ppm, as measured by colorimetry;superoxide radical present at a concentration of about 94 μM, as measured by 5-(Diisopropoxyphosphoryl)-5-1-pyrroline-N-oxide nuclear magnetic resonance (DIPPMPO-NMR); andhydroxyl radical present at a concentration of about 241 μM, as measured by DIPPMPO-NMR. 6. The method of claim 1, further comprising topically administering the formulation to a user. 7. The method of claim 1, wherein the composition is a topical formulation. 8. The method of claim 1, wherein the salt further comprises one or more of potassium iodide, sodium iodide, lithium chloride, copper chloride, potassium chloride, and calcium chloride. 9. The method of claim 1, wherein the rheology modifier comprises sodium magnesium silicate. 10. The method of claim 1, wherein the rheology modifier is at a concentration of between 2% and 5% by weight of the composition. 11. The method of claim 1, wherein the pH is between 6 and 9. 12. The method of claim 1, wherein the electrolyzed saline solution comprises less than 0.1 ppt organic material. 13. The method of claim 1, wherein the composition is a gel formulation comprising between 0.1% and 1.0% salt by weight, wherein the saline solution is electrolyzed by placing a concentrically arranged anode and cathode within the saline solution and applying a DC voltage of less than 30 volts across the anode and cathode. 14. The method of claim 13, wherein the rheology modifier comprises sodium magnesium fluorosilicate. 15. The method of claim 13, wherein the rheology modifier comprises between 2 to 5% by weight of the gel formulation. 16. The method of claim 13, wherein the buffer comprises sodium phosphate monobasic. 17. The method of claim 13, wherein the gel formulation comprises a pH of between 5.6 and 7.0. 18. The method of claim 13, further comprising hypochlorous acid present at a concentration of between 16 and 24 ppm, as measured by colorimetry. 19. The method of claim 1, wherein the ultrapure water comprises less than 10 ppm total dissolved solids. 20. The method of claim 1, wherein the salinated water is electrolyzed at the temperature of about 4.5 to about 5.8° C. for about 8 hours. 21. The method of claim 1, wherein the composition includes a hypochlorite-superoxide complex. 22. The method of claim 1, wherein the rheology modifier comprises at least one of sodium magnesium fluorosilicate and sodium magnesium silicate. 23. The method of claim 3, wherein the buffering agent is sodium phosphate monobasic.