[특허]Prolyl hydroxylase inhibitors and methods of use

[미국특허] Prolyl hydroxylase inhibitors and methods of use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07D-417/04 C07D-401/10 C07D-405/04 C07D-401/04 C07D-213/81 C07C-235/60 C07C-237/42 C07C-255/57 C07D-213/65 C07D-405/10 C07D-295/192
출원번호	US-0854080 (2015-09-15)
등록번호	US-9598370 (2017-03-21)
발명자 / 주소	Kawamoto, Richard Masaru Wu, Shengde Evdokimov, Artem G. Greis, Kenneth D. Boyer, Angelique Sun Warshakoon, Namal C.
출원인 / 주소	Akebia Therapeutics, Inc.
대리인 / 주소	Jones Day
인용정보	피인용 횟수 : 4 인용 특허 : 22

초록 ▼

The present disclosure relates to HIF-1α prolyl hydroxylase inhibitors, compositions which comprise the HIF-1α prolyl hydroxylase inhibitors described herein and to methods for controlling, inter alia, Peripheral Vascular Disease (PVD), Coronary Artery Disease (CAD), heart failure, ischemia, and ane

대표청구항 ▼

1. A compound having the formula: 2. A pharmaceutical composition comprising: A) the compound according to claim 1; andB) one or more pharmaceutically acceptable excipients. 3. A compound having the formula: 4. A pharmaceutical composition comprising: A) the compound according to claim 3; andB) one or more pharmaceutically acceptable excipients. 5. A compound having the formula: wherein:R6 is hydrogen, methyl, or ethyl;R7a and R7b are each independently:i) hydrogen; orii) methyl. 6. The compound according to claim 5, wherein the compound is: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester;{[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester;5-(3-Chlorophenyl)-N-(2-amino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide;5-(3-Chlorophenyl)-N-(2-methylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide; and5-(3-Chlorophenyl)-N-(2-dimethylamino-2-oxoethyl)-3-hydroxylpyridin-2-yl amide. 7. A pharmaceutical composition comprising: A) one or more compounds according to claim 6; andB) one or more pharmaceutically acceptable excipients. 8. The composition according to claim 7, wherein the compound is: {[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid methyl ester; or{[5-(3-Chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid ethyl ester.

이 특허에 인용된 특허 (22) 인용/피인용 타임라인 분석

Weidmann Klaus,DEX ; Baringhaus Karl-Heinz,DEX ; Tschank Georg,DEX ; Bickel Martin,DEX, 3-hydroxypyridine-2-carboxamidoesters, their preparation and their use as pharmaceuticals.
상세보기
Kanji Takahashi JP; Tsuneyuki Sugiura JP, Aminobutyric acid derivatives.
상세보기
Shalwitz, Robert; Gardner, Joseph H., Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer.
상세보기
Seeley, Todd W.; Liu, David Y.; Klaus, Stephen J., Compounds and methods for treatment of cancer.
상세보기
Zhu, Xiaotian, Crystal of a kinase-ligand complex and methods of use.
상세보기
Evdokimov, Artem Gennady; Kawamoto, Richard Masaru; Boyer, Angelique Sun; Mekel, Marlene Jan; Pokross, Matthew Eugene; Walter, Jr., Richard Lee, Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase.
상세보기
Evdokimov, Artem Gennady; Kawamoto, Richard Masaru; Boyer, Angelique Sun; Mekel, Marlene Jan; Pokross, Matthew Eugene; Walter, Jr., Richard Lee, Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase.
상세보기
Kress Thomas J. (Indianapolis IN) Varie David L. (Indianapolis IN), Crystalline salt of 4-(di-N-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]-indole.
상세보기
Eberhardt Hans (Biberach an der Riss DT) Brickl Rolf Stefan (Biberach an der Riss DT), Dermatological compositions containing an acylamino-carboxylic acid or an alkyl ester thereof.
상세보기
Lanthier, Christopher M.; Gorin, Boris; Oudenes, Jan; Dixon, Craig Edward; Lu, Alan Qingbo; Copp, James Densmore; Janusz, John Michael, Process for preparing [(3-hydroxypyridine-2-carbonyl)amino]alkanoic acids, esters and amides.
상세보기
Kawamoto, Richard M.; Wu, Shengde; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun; Warshakoon, Namal C., Prolyl hydroxylase inhibitors and method of use.
상세보기
Kawamoto, Richard Masaru; Wu, Shengde; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun; Warshakoon, Namal C., Prolyl hydroxylase inhibitors and methods of use.
상세보기
Kawamoto, Richard Masaru; Wu, Shengde; Warshakoon, Namal C.; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun, Prolyl hydroxylase inhibitors and methods of use.
상세보기
Kawamoto, Richard Masaru; Wu, Shengde; Warshakoon, Namal C.; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun, Prolyl hydroxylase inhibitors and methods of use.
상세보기
Wu, Shengde; Warshakoon, Namal C.; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun; Kawamoto, Richard Masaru, Prolyl hydroxylase inhibitors and methods of use.
상세보기
Wu, Shengde; Warshakoon, Namal C.; Evdokimov, Artem G.; Greis, Kenneth D.; Boyer, Angelique Sun; Kawamoto, Richard Masaru, Prolyl hydroxylase inhibitors and methods of use.
상세보기
McKnight, Steven L.; Bruick, Richard K., Prolyl-4-hydroxylases.
상세보기
Weidmann Klaus (Kronberg DEX) Baringhaus Karl-Heinz (Wolfersheim DEX) Tschank Georg (Klein-Winternheim DEX) Bickel Martin (Bad Homburg DEX), Substituted heterocyclic carboxamide esters, their preparation and their use as pharmaceuticals.
상세보기
Weidmann Klaus (Kronberg DEX) Baringhaus Karl-Heinz (Wolfersheim DEX) Tschank Georg (Klein-Winternheim DEX) Bickel Martin (Bad Homburg DEX), Substituted heterocyclic carboxyamides, their preparation and their use as pharmaceuticals.
상세보기
Durley,Richard C, Substituted pyrimidinones.
상세보기
Guenzler-Pukall, Volkmar; Klaus, Stephen J.; Langsetmo Parobok, Ingrid; Seeley, Todd W., Treatment of diabetes.
상세보기
Rowland David (Nobel CAX), Vitamin/mineral composition.
상세보기

이 특허를 인용한 특허 (4) 인용/피인용 타임라인 분석

Lanthier, Christopher M.; Gorin, Boris; Oudenes, Jan; Dixon, Craig Edward; Lu, Alan Quigbo; Copp, James Denmore; Janusz, John Michael, Process for preparing [(3-hydroxypyridine-2-carbonyl)amino] alkanoic acids, esters and amides.
상세보기
Hanselmann, Roger; Luong, Anne, Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof.
상세보기
Copp, James Densmore; Newman, Ann W.; Luong, Anne, Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof.
상세보기
Copp, James Densmore; Newman, Ann W.; Luong, Anne, Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof.
상세보기

활용도 분석정보

상세보기

다운로드

내보내기

활용도 Top5 특허

해당 특허가 속한 카테고리에서 활용도가 높은 상위 5개 콘텐츠를 보여줍니다.
더보기 버튼을 클릭하시면 더 많은 관련자료를 살펴볼 수 있습니다.

내보내기 메뉴

내보내기 구분

파일저장
인쇄
메일전송

구성항목

기본정보
상세정보

관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC

저장형식

Text(ASCII format)
Excel format
PIAS분석(.xls)

메일정보

받는사람 (필수): @
보내는사람 (선택): @
제목
내용: KISTI 검색결과 이메일 서비스

안내

총 건의 자료가 검색되었습니다.

다운받으실 자료의 인덱스를 입력하세요. (1-10,000)

검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다.

데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요)

다운로드 파일은 UTF-8 형태로 저장됩니다.
파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오.

Text(ASCII format)
Excel format

AI-Helper ※ AI-Helper는 을 사용합니다.

AI-Helper

안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

연합인증

[미국특허] Prolyl hydroxylase inhibitors and methods of use 원문보기