[특허]Dipeptide analogs for treating conditions associated with amyloid fibril formation

[미국특허] Dipeptide analogs for treating conditions associated with amyloid fibril formation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/00 A61P-003/04 A61P-025/00 A61K-038/05 C07D-209/20 C07K-005/078
출원번호	US-0805490 (2015-07-22)
등록번호	US-9630989 (2017-04-25)
우선권정보	EP-10191253 (2010-11-15)
발명자 / 주소	Gazit, Ehud Amir, Yaniv Buzhansky, Ludmila Abel, Ulrich Frydman-Marom, Anat
출원인 / 주소	Ramot at Tel-Aviv University Ltd.
인용정보	피인용 횟수 : 0 인용 특허 : 33

초록 ▼

Dipeptide analogs comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety derived from alpha-aminoisobutyric acid (Aib) are disclosed. The dipeptide analogs exhibit an improved performance in inhibiting amyloid fibril formation, as compared to previously described dipeptides. Compositions containing the dipetide analogs and uses thereof in treating amyloid-associated diseases and disorders are also disclosed.

대표청구항 ▼

1. A method of treating an amyloid-associated disease or disorder in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount a dipeptide analog comprising a tryptophan (Trp) moiety coupled to a beta-sheet breaker moiety, with the proviso that either said Trp moiety is not Trp or said beta-sheet breaker moiety is not α-aminoisobutyric acid (Aib) or that said dipeptide analog is not an ester of a Trp-Aib dipeptide, wherein said beta sheet breaker moiety has a chemical structure selected from the group consisting of: and wherein said Trp moiety has a chemical structure selected from the group consisting of: thereby treating the disease or disorder. 2. The method of claim 1, wherein said dipeptide analog is represented by a chemical structure selected from the group consisting of: 3. The method of claim 1, wherein said amyloid-associated disease is selected from the group consisting of type II diabetes mellitus, Alzheimer's disease (AD), early onset Alzheimer's disease, late onset Alzheimer's disease, presymptomatic Alzheimer's disease, Parkinson's disease, SAA amyloidosis, hereditary Icelandic syndrome, multiple myeloma, medullary carcinoma, aortic medical amyloid, Insulin injection amyloidosis, prion-systematic amyloidosis, choronic inflammation amyloidosis, Huntington's disease, senile systemic amyloidosis, pituitary gland amyloidosis, Hereditary renal amyloidosis, familial British dementia, Finnish hereditary amyloidosis, familial non-neuropathic amyloidosis, amyloid-related ocular diseases and disorders and prion diseases.

이 특허에 인용된 특허 (33) 인용/피인용 타임라인 분석

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A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Dipeptide analogs for treating conditions associated with amyloid fibril formation 원문보기