Systems and methods for multi-purpose analysis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C12Q-001/68
G01N-033/48
G01N-035/02
C12Q-001/00
C12Q-001/02
C12Q-001/28
G01N-030/02
G01N-033/559
G01N-033/566
G01N-033/86
G01N-035/00
출원번호
US-0244949
(2011-09-26)
등록번호
US-9632102
(2017-04-25)
발명자
/ 주소
Holmes, Elizabeth
Balwani, Sunny
출원인 / 주소
Theranos, Inc.
인용정보
피인용 횟수 :
0인용 특허 :
225
초록▼
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more module
Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.
대표청구항▼
1. A system for processing a sample, comprising: a plurality of modules and a supporting structure configured to support at least a first module and a second module among the plurality of modules, wherein the first and second modules are each: (a) detachable from said supporting structure and interc
1. A system for processing a sample, comprising: a plurality of modules and a supporting structure configured to support at least a first module and a second module among the plurality of modules, wherein the first and second modules are each: (a) detachable from said supporting structure and interchangeable with another module of the system;(b) configured to perform using said sample but without the aid of another module in said system (i) at least one sample preparation procedure selected from the group consisting of sample processing, centrifugation, and magnetic separation, and (ii) at least one type of assay selected from the group consisting of immunoassay, nucleic acid assay, receptor-based assay, cytometric assay, colorimetric assay, enzymatic assay, electrophoretic assay, electrochemical assay, spectroscopic assay, chromatographic assay, microscopic assay, topographic assay, calorimetric assay, turbidimetric assay, agglutination assay, radioisotope assay, viscometric assay, coagulation assay, clotting time assay, protein synthesis assay, histological assay, culture assay, osmolarity assay, and combinations thereof; and(c) configured to be in electrical, electro-magnetical or optoelectronic communication with a controller, said controller being programmed to provide one or more instructions to, and receive responses from, the module to evaluate indicators of sample or system performance, andwherein the first and second modules each comprise a centrifuge, wherein each centrifuge is configured to receive and centrifuge the sample or a portion thereof. 2. The system of claim 1, wherein the supporting structure is a housing that encloses the first and second modules. 3. The system of claim 2, wherein the housing provides a power source. 4. The system of claim 2, wherein the housing provides a communication unit. 5. The system of claim 1 further comprising an imaging device configured to image one or more of: (a) the sample collected, (b) processing of the sample, and (c) reactions performed on the system. 6. The system of claim 1 wherein the controller is integral to the supporting structure. 7. The system of claim 6, wherein the controller is further configured to, based on the evaluation, send instructions as needed to the system to utilize another module within the system to perform at least one sample preparation procedure or the at least one type of assay. 8. The system of claim 7, wherein said evaluation of indicators of sample or system performance identifies malfunctioning of one or more of the modules, wherein said instructions as needed are sent to said system, and wherein sending said instructions to said system effects correction of said malfunctioning in real time. 9. The system of claim 1 wherein the controller is external to the system. 10. The system of claim 1 wherein the system is configured to permit hot-swapping of the first module or the second module with another module of the system. 11. The system of claim 10, wherein the another module is the second module or the first module, respectively. 12. The system of claim 10, wherein the system is configured to update a list of modules available for use by the system and to determine which resources are available for processing the biological sample when the first module or the second module is hot-swapped with another module of the system. 13. The system of claim 1, wherein the system is configured to update a list of modules available for use by the system and to determine which resources are available for processing the biological sample. 14. The system of claim 1, wherein the first module or the second module comprises an assay station configured to perform one or more types of assays, wherein the assay station is configured to receive one or more individually addressable assay units. 15. The system of claim 14 wherein each assay unit is fluidically isolated from one another. 16. The system of claim 14 wherein a given type of assay performed within said individually addressable assay unit is configured to yield a detectable signal. 17. The system of claim 16 wherein the first module or the second module comprises a sample handling system configured to transport said one or more individually addressable assay units to a location in which the signal is detectable by a detection system.
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이 특허에 인용된 특허 (225)
Shapiro Justin J. (c/o Labindustries ; Inc. ; 620 Hearst Ave. Berkeley CA 94710-1992), Adjustable volume pipette sampler.
Johnson, Kristianne E; Reasoner, Kelly J; Gardner, Jr., Richard Lynn; Coffin, Paul C, Apparatus and method for retrieving data related to a data cartridge in a media storage system.
Smith Lloyd M. (Madison WI) Hood Leroy E. (Pasadena CA) Hunkapiller Michael W. (San Carlos CA) Hunkapiller Tim J. (Pasadena CA), Automated DNA sequencing technique.
Pang Wing S. ; Gross Mark ; Tanumihardja Hendra ; Rauskolb Ruediger F. ; Pedrazzini G. Andrea,ITX ; Allen Santiago F., Automated sample processing system including automatic centrifuge device.
Ortyn, William E.; Basiji, David A.; Morrissey, Philip; George, Thaddeus; Hall, Brian; Zimmerman, Cathleen; Perry, David, Blood and cell analysis using an imaging flow cytometer.
Hillman Robert S. (Cupertino CA) Cobb Michael E. (Sunnyvale CA) Allen Jim (Los Altos CA) Gibbons Ian (Menlo Park CA) Ostoich Vladimir (San Jose CA) Winfrey Laura J. (Belmont CA), Capillary flow device.
Dunn Chadwick M. (Gurnee IL) Grandone Cass J. (Lake Forest IL) Herchenbach Stephen L. (Grayslake IL) Nelson Robert J. (Highland Park IL) Tyranski James T. (Oakwood Hills IL) Zuck Gary L. (Prospect He, Carousel for assay specimen carrier.
Roger Hammer ; William Reid ; David Storvick ; Richard A. Riedel ; James S. Hutchinson ; Daniel Kennedy ; Douglas E. Boyd ; James Ramey ; John W. Stoughton ; Glen T. Mathews, Cartridge-based analytical instrument using centrifugal force/pressure for metering/transport of fluids.
Brown, Gene W.; Merritt, Steven J.; Calcaterra, Farrell F.; Beard, John H.; May, David F.; Krempel, Louis A., Centrifugal filter for removing soot from engine oil.
Hayter, Paul G.; Sharma, Manoj K.; Ohara, Timothy J.; Poulos, Darwin; Aquino, Maria, Diagnostic kit with a memory storing test strip calibration codes and related methods.
Carter Nigel F. (Oxon GB2) Chambers Geoffrey R. (Northwood Middlesex GB2) Hughes Graham J. (Oxford GB2) Scott Steven (Oxon GB2) Sanghera Gurdial S. (Oxford GB2) Watkin Jared L. (Oxon GB2), Electrochemical sensor.
Torti Victor A. (Brookline NH) Nelson Gary E. (Hollis NH) Keene Laurence (Brookline MA) Kalmakis George P. (Reading MA), Expandable multi-channel pipetter.
Queen Cary L. (Los Altos CA) Co Man Sung (Cupertino CA) Schneider William P. (Mountain View CA) Landolfi Nicholas F. (Milpitas CA) Coelingh Kathleen L. (San Francisco CA) Selick Harold E. (Belmont CA, Humanized immunoglobulins.
Farzad Pourahmadi ; William A. McMillan ; Jesus Ching ; Ronald Chang ; Lee A. Christel ; Gregory T. A. Kovacs ; M. Allen Northrup ; Kurt E. Petersen, Integrated fluid manipulation cartridge.
Schleifer Arthur ; Caren Michael P. ; Leonard Leslie A. ; Hotz Charles Z. ; Perbost Michel G. M., Method and apparatus for fabricating replicate arrays of nucleic acid molecules.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method and apparatus for performing a magnetic separation purification procedure on a sample solution.
Ried Thomas ; MacVille Merryn V. E.,NLX ; Hopman Anton H. N.,NLX, Methods for assessing genetic and phenotypic markers by simultaneous multicolor visualization of chromogenic dyes using brightfield microscopy and spectral imaging.
Grtzel Michael (St-Sulpice CHX) Fraser David (Vevey CHX) Zakeeruddin Shaik M. (Renens CHX) Nazeeruddin Mohammed K. (Chavannes CHX), Mono, bis or tris(substituted 2,2′-bipyridine) iron, ruthenium, osmium or vanadium complexes and their methods of prepa.
Modlin, Douglas N.; Owicki, John C.; Petersen, Jon F.; French, Todd E.; Wright, Carl L.; Ruiz, Jeanne A.; Bechtel, Lorne E., Multi-mode light detection system.
Moring Stephen E. ; Bodner Kevin S. ; Halsey Jason H. ; Hoshizaki Jon ; Jackson Joseph ; Madden Alfred P. ; Oldham Mark F. ; Reed Mark T., Multi-well microfiltration apparatus.
Mark J. Rice ; Robert H. Sweat, Jr. ; James M. Rioux ; William T. Williams ; Wilson Routt, Non-invasive measurement of blood components using retinal imaging.
Queen Cary L. (Los Altos CA) Schneider William P. (Mountain View CA) Selick Harold E. (Belmont CA), Polynucleotides encoding improved humanized immunoglobulins.
Padmanabhan, Aravind; Cox, James A.; Fritz, Bernard S.; Rezachek, Tom M.; Reutiman, Peter L.; Bardell, Ron L.; Cabuz, Cleopatra, Portable sample analyzer system.
Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
Muller Uwe R. (Kendall County IL) Mika Lawrence J. (Naperville IL) Lindley Donald J. (Naperville IL) Wisner Ernest J. (Elgin IL), Processing of slide mounted material.
Holen, James T.; Hicaro, Jr., Enrique; Putterman, Caryn G.; Huang, Tung-Ming; Merkh, Carl W., Reaction cartridge and carousel for biological sample analyzer.
Cabilly Shmuel (Monrovia CA) Heyneker Herbert L. (Burlingame CA) Holmes William E. (Pacifica CA) Riggs Arthur D. (La Verne CA) Wetzel Ronald B. (San Francisco CA), Recombinant immunoglobin preparations.
Gelfand David H. (Oakland CA) Myers Thomas W. (Emeryville CA), Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription.
Seaton William Ernest (Chesterfield MO) Shine David B. (University City MO) Drager Craig (Ballwin MO), Sample card transport method for biological sample testing machine.
Watson, Leslie Robert; Tschopp, Christoph Friedrich; Weaver, Ross Andrew; Henderson, Ian David; Kuiper, Pieter Adriaan; Decosterd, Christian Darrel, Sample distribution apparatus/system.
Campbell David A. ; Antonenko Valery V. ; Selick Harold E. ; Gavin Robert M. ; Ida Satoru ; Muir Arthur H., System and method for solid-phase parallel synthesis of a combinatorial collection of compounds.
Reichler Allen S. (Owing Mills MD) Antol David J. (Baldwin MD) Lamos Michael L. (Westminster MD) Bourdelle Peter A. (Glen Rock PA) Hildebrand Scott D. (Red Lion PA), System for nucleic acid based diagnostic assay.
Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence F.; Knight, Byron J.; Heinz, Robert E.; Macioszek, Jerzy A.; Davis, Christopher B.; Scalese, Robert F., System for performing multi-formatted assays.
Ludowise, Peter D.; Whitman, David A.; Armantrout, Kyle C.; Exner, Maurice; Jacky, Lucien A. E.; Tabb, Michelle, Systems and methods for detecting the presence of a selected volume of material in a sample processing device.
Spence, Simon Jonathon; Grant, Richard Alexander; Peele, Timothy Doyle; Hunter, William Samuel; Abdelmoteleb, Ashraf F.; Kneen, David Thomas; Neil, Robert Alister; Harris, Simon, Systems and methods for processing samples in a closed container, and related devices.
Jaynes, Allison; Bucchieri, Vittorio G.; Schmidt, Albert L., Systems and methods for providing connection status and location information in a wireless networking environment.
Roy, Shaunak; Takahashi, Malissa; Gibbons, Ian; Ku, Edmond; Dang, Thanh; Burd, Tammy; Vollmer, Adam; Holmes, Elizabeth A., Systems and methods of fluidic sample processing.
Roy, Shaunak; Takahashi, Melissa; Gibbons, Ian; Ku, Edmond; Dang, Thanh; Burd, Tammy; Vollmer, Adam; Holmes, Elizabeth A., Systems and methods of fluidic sample processing.
Boeckel John W. (1232 Georgia Hill Rd. Southbury CT 06488-0358) Parisi Michael J. (5207 Main St. Trumbull CT 06611), Thermoelectric cooling centrifuge.
Smith John A. (East Orange NJ) Miller Jack H. (Morristown NJ) Schilling Russell C. (Denville NJ) North ; Jr. Howard L. (Newfoundland NJ), Triac centrifuge.
Levene, Michael J.; Korlach, Jonas; Turner, Stephen W.; Craighead, Harold G.; Webb, Watt W., Zero-mode clad waveguides for performing spectroscopy with confined effective observation volumes.
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