초록 ▼

The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the co

The present technology provides intravaginal devices designed to deliver lubricants to the vagina for a sustained period of time. The intravaginal devices include a first segment comprising an outer surface and a lumen containing a lubricant, wherein the first segment is configured to deliver the contents of the lumen to the outer surface, and the first segment comprises a polymer selected from the group consisting of a hydrophilic, semi-permeable elastomer and a hydrophobic elastomer. The lubricant may be an aqueous lubricant. The present technology further provides an intravaginal device including a solid first segment that includes a hydrophilic semi-permeable elastomer, an outer surface and an aqueous lubricant, wherein the first segment is configured to deliver the aqueous lubricant to the outer surface.

대표청구항 ▼

1. An intravaginal device comprising: a first segment comprising: an outer surface anda lumen containing an aqueous lubricant,wherein the first segment comprises a water-swellable, hydrophilic polyether polyurethane and is configured to deliver the contents of the lumen to the outer surface by diffu

1. An intravaginal device comprising: a first segment comprising: an outer surface anda lumen containing an aqueous lubricant,wherein the first segment comprises a water-swellable, hydrophilic polyether polyurethane and is configured to deliver the contents of the lumen to the outer surface by diffusion; andthe aqueous lubricant comprises water and about 3 wt % to about 99 wt % propylene glycol. 2. The intravaginal device of claim 1 wherein the aqueous lubricant has a pH of about 3 to about 6. 3. The intravaginal device of claim 1 wherein the aqueous lubricant further comprises one or more salts, nonaqueous solvents, C1-8 carboxylic acids, glucose, antioxidants, preservatives, surfactants, fragrance, flavoring agents, colors, or sweeteners. 4. The intravaginal device of claim 3 where the aqueous lubricant has a pH from 3 to 6. 5. The intravaginal device of claim 1 wherein the aqueous lubricant further comprises one or more salts, propylene glycol, glycerol, lactic acid, acetic acid, glucose, BHT, ascorbic acid, sorbital, sorbic acid, parabens, EDTA, sodium benzoate, tocopherol, polysorbate 20, polysorbate 60, sorbate salts, saccharine, or aspartame. 6. The intravaginal device of claim 1 wherein the aqueous lubricant is buffered at an acidic pH to promote the natural acidity of the vagina. 7. The intravaginal device of claim 1 wherein the aqueous lubricant further comprises vaginal fluid simulant, about 5 to about 50 mM lactic acid, an acetic acid buffer at a pH of about 3.5 to about 5.0, and optionally about 5 to about 50 mM glucose. 8. A method of lubrication comprising administering an intravaginal device of claim 1 to a female in need of vaginal lubrication. 9. The method of claim 8 wherein the device delivers 0.001 -2000 mg of aqueous lubricant to the outer surface of the device per day. 10. The method of claim 8 wherein the device delivers from 0.001-1000 mg of aqueous lubricant to the outer surface of the device per day. 11. The intravaginal device of claim 1, wherein the aqueous lubricant further comprises one or more of benzalkonium chloride, benzethonium chloride, benzoic acid, benzyl alcohol, boric acid, calcium lactate, glycerin, glacial acetic acid, hibitane acetate, methyl paraben, phenylethyl alcohol, potassium sorbate, propylene glycol, propyl paraben, sodium benzoate, sodium ethyl paraben, sodium propionate, sorbic acid, sorbital, or tocopherol. 12. An intravaginal device comprising: a first segment comprising: an outer surface anda lumen containing an aqueous lubricant,wherein the first segment comprises a water-swellable, hydrophilic polyether polyurethane and is configured to deliver the contents of the lumen to the outer surface by diffusion; andthe aqueous lubricant comprises one or more of pyridine, squalene, urea, complex alcohols, aldehydes, ketones, stearic acid, stearate, isopropyl palmitate, petrolatum, Aloe Vera, cucumus sativus extract, helianthus annulus seed oil, soybean sterol, vitamin E acetate, vitamin A palmitate, provitamin B5, sodium acrylate/acryloyldimethyl taurate copolymer, dimethicone, glyceryl stearate, cetyl alcohol, lecithin, mineral water, sodium PCA, potassium lactate, collagen, amino acids, triethanolamine, DMDM, hydantoin, iodopropynyl, butylcarbamate, disodium EDTA, or titanium dioxide. 13. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one or more of agarose, aluminum magnesium silicate, carbomer, carbopol, carrageenans, dermatan sulfate, ethyl cellulose, silicon dioxide, guar gum, hydroxyethyl cellulose, hydroxyethyl methacrylate, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, maltodextran, polyacrylamide, polycarbophil, polyethylene glycol, polyethylene oxide, pluronic/poloxamer, polyvinyl alcohol, sodium alginate, sodium carboxymethyl cellulose, sodium hyaluronate, sucrose, or xanthan gum. 14. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one or more of adipic acid, alkyl fumarate, aluminium sulfate, calcium acetate, calcium carbonate, calcium lactate, citric acid, glacial acetic acid, glutamic acid, glycine, hydrochloric acid, lactic acid, methionine, nitric acid, phosphoric acid, potassium bitartarate, sodium dihydrogen citrate, sodium citrate, sodium dibasic phosphate, sodium carbonate, sodium bicarbonate, sodium hydroxide, sodium lactate, sodium monobasic phosphate, stannous chloride, succinic acid, or tartaric acid. 15. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one or more of benzyl alcohol, beta cyclodextrin, polyoxyethylene 20 cetyl ether, cremophor, piperazine hexahydrate, pluronic /poloxamer, polyoxyethylene lauryl ether, polyoxyethylene stearate, polysorbates, polyvinyl alcohol, silicone, sodium cetearyl sulfate, sodium lauryl sulfate, sorbate salts, or sorbitan esters. 16. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one omr more of ascorbic acid, butylated hydroxyanisole, butylated hydroxytoluene, citric acid, phosphoric acid, sodium ascorbate, sodium metabisulfite, tartaric acid, or tertiary butyl hydroquinone. 17. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one or more of acacia, allantoin, aluminium magnesium silicate, bentonite, bleached bees' wax, carbomer, polyoxyethylene 20 cetyl ether, cetostearyl alcohol, cetyl esters wax, cetyl palmitate, cholesterol, choleth, colloidal silicon dioxide, cremophor, diglycol stearate, glycerin, glyceryl monostearate, guar gum, hydrous lanolin, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, isopropyl myristate, lactose, lanolin, methyl cellulose, mineral oil, palm oil, polyoxyethylene lauryl ether, polyoxyethylene stearates, polyethylene glycol, pluronic/poloxamer, polysorbates, propylene glycol monostearate, octyl dodecanol, sodium carboxymethyl cellulose, sodium lauryl sulfate, sodium monobasic phosphate, sorbitan esters, spermaceti wax, stearyl alcohol, or triethanolamine. 18. The intravaginal device of claim 12, wherein the aqueous lubricant further comprises one or more of aspartame, dextrose, maltose, mannitol, saccharine, or xylitol. 19. A method of lubrication comprising administering an intravaginal device of claim 12 to a female in need of vaginal lubrication. 20. The method of claim 19 wherein the device delivers 0.001-2000 mg of aqueous lubricant to the outer surface of the device per day.