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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0620859 (2015-02-12) |
| 등록번호 | US-9649156 (2017-05-16) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 1053 |
A first spacing structure is provided at a distal end of a first catheter. The first spacing structure is configured to position at least one arterial electrode at a predefined distance away from a wall of the renal artery. A second spacing structure is provided at the distal end of the first cathet
A first spacing structure is provided at a distal end of a first catheter. The first spacing structure is configured to position at least one arterial electrode at a predefined distance away from a wall of the renal artery. A second spacing structure is provided at the distal end of the first catheter or at a distal end of a second catheter. The second spacing structure is configured to position at least one aortal electrode at a predefined distance away from a wall of the aorta. The arterial and aortal electrodes are operable as a bipolar electrode arrangement. The first and second spacing structures respectively maintain the arterial and aortal electrodes at a predefined distance away from the renal artery and aortal walls while electrical energy sufficient to ablate perivascular nerve tissue adjacent the renal artery and aortal walls is delivered by the bipolar electrode arrangement.
1. An apparatus, comprising: a catheter having a proximal end and a distal end;a first structure provided at the distal end of the catheter, the first structure configured for deployment in a renal artery of a patient, the first structure configured to position at least a first electrode within the
1. An apparatus, comprising: a catheter having a proximal end and a distal end;a first structure provided at the distal end of the catheter, the first structure configured for deployment in a renal artery of a patient, the first structure configured to position at least a first electrode within the renal artery;a second structure provided at the distal end of the catheter proximal to the first structure, the second structure configured for deployment in an aorta of the patient, proximate the renal artery and to position at least a second electrode within the aorta;the at least first and second electrodes being off-wall electrodes and operable as a bipolar electrode arrangement; andeach of the first and second structures respectively being configured to maintain the at least first and second electrodes within the renal artery and the aorta, respectively, and the apparatus being configured to deliver electrical energy sufficient to ablate perivascular tissue comprising renal nerves and ganglia proximate a renal ostium through the bipolar electrode arrangement;wherein the first structure extends from a distal end of the second structure; andwherein the first and second structures each comprise helical structures. 2. The apparatus of claim 1, wherein: the first structure includes a helical wire having a first diameter in its deployed configuration; andthe second structure includes a second helical wire having a second diameter in its deployed configuration;wherein the second diameter is greater than the first diameter. 3. The apparatus of claim 2, comprising a sheath defining a lumen dimensioned to receive the apparatus in a non-deployed configuration, wherein the sheath is retractable to allow the first and second helical wires to expand to their helical deployed configurations. 4. The apparatus of claim 1, wherein the first structure comprises a first helical structure having a first diameter, the second structure comprises a second helical structure having a second diameter that is greater than the first diameter by a factor of 2 or more. 5. The apparatus of claim 1, wherein each off-wall electrode is configured to be maintained at a separation distance ranging from 0.5 mm to 3 mm away from an adjacent vessel wall. 6. An apparatus, comprising: a catheter having a proximal end and a distal end;a first expandable structure provided at the distal end of the catheter, the first expandable structure including at least one off-wall electrode and being configured for deployment in a renal artery of a patient;a second expandable structure provided at the distal end of the catheter, the second expandable structure including at least one off-wall electrode and being configured for deployment in an aorta of a patient spaced apart from the at least one electrode of the first expandable structure, wherein the first expandable structure extends from a distal end of the second expandable structure;the respective at least one electrodes of the first and second expandable structures operable as a bipolar electrode arrangement; andthe first and second expandable structures being configured to maintain their respective at least one electrodes in the spaced apart configuration within the renal artery and aorta, respectively, and the apparatus being configured to deliver electrical energy sufficient to ablate target perivascular tissue comprising renal nerves and ganglia adjacent a renal ostium through the bipolar electrode arrangement. 7. The apparatus of claim 6, wherein at least one of the first and second expandable structures comprises a helical wire. 8. The apparatus of claim 6, further comprising an external control unit electrically coupled to each of the at least one electrodes and configured to supply energy to each of the at least one electrodes in accordance with one or more predetermined activation patterns or sequences. 9. The apparatus of claim 6, wherein one or both of the first and second expandable structures comprises a shape-memory member or a superelastic member. 10. The apparatus of claim 6, wherein the first expandable structure comprises a first expandable helical structure having a first diameter, the second expandable structure comprises a second expandable helical structure having a second diameter that is greater than the first diameter by a factor of 2 or more. 11. The apparatus of claim 6, wherein each off-wall electrode is configured to be maintained at a separation distance ranging from 0.5 mm to 3 mm away from an adjacent vessel wall. 12. A method of ablating tissue, comprising: inserting a catheter into a patient's body, the catheter having first and second helical support structures disposed at a distal end thereof, each of the first and second helical support structures including at least one off wall electrode;positioning the first helical support structure inside a renal artery;positioning the second helical support structure inside an aorta, wherein the electrodes on the respective first and second helical support structures are configured for operation as a bipolar electrode arrangement;ablating target perivascular tissue comprising renal nerves and ganglia adjacent a renal ostium by delivering energy through the bipolar electrode arrangement while the first and second helical support structures remain in the renal artery and aorta, respectively. 13. The method of claim 12, wherein the first helical support structure has a first diameter, the second helical support structure comprises has a second diameter that is greater than the first diameter by a factor of 2 or more. 14. The method of claim 12, wherein each off-wall electrode is maintained at a separation distance ranging from 0.5 mm to 3 mm away from an adjacent vessel wall.
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