[미국특허]
System and method for blood filtering and/or treatment
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-001/14
A61M-001/38
A61M-001/34
A61M-001/16
A61M-001/36
A61M-005/165
A61M-039/02
출원번호
US-0368537
(2012-12-27)
등록번호
US-9649427
(2017-05-16)
국제출원번호
PCT/IL2012/050558
(2012-12-27)
국제공개번호
WO2013/098823
(2013-07-04)
발명자
/ 주소
Laster, Morris
출원인 / 주소
XEREM MEDICAL LTD.
대리인 / 주소
Clements Bernard Walker PLLC
인용정보
피인용 횟수 :
0인용 특허 :
44
초록▼
A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a bloo
A system for filtering or treating blood of a subject is provided herein. The system includes a bone port for establishing fluid communication with a bone marrow of the bone and a return port for returning blood from the bone marrow to a circulation of the subject. The system further includes a blood treatment or filtering device interposed between the bone and return ports thereby establishing a mini-circulatory system.
대표청구항▼
1. A system for filtering blood of a subject, the system comprising: a bone port fixable to a bone and configured for establishing fluid communication with a bone marrow of said bone;a fluid fractioning device capable of selectively fractioning blood flowing out of said bone marrow to thereby retain
1. A system for filtering blood of a subject, the system comprising: a bone port fixable to a bone and configured for establishing fluid communication with a bone marrow of said bone;a fluid fractioning device capable of selectively fractioning blood flowing out of said bone marrow to thereby retain a fraction of said blood;a first fluid conduit connectable between said bone port and said fluid fractioning device, and configured to establish fluid communication therebetween;a return port configured for returning a non-retained fraction of said blood to a circulation of the subject; anda second fluid conduit connectable between said fluid fractioning device and said return port, and configured to establish fluid communication therebetween. 2. The system of claim 1, further comprising a third fluid conduit connectable between said fluid fractioning device and a bladder, a Genitourinary system, or a reservoir, and configured for routing said fraction of said blood retained by said fluid fractioning device to said bladder, said Genitourinary system, or said reservoir. 3. The system of claim 2, further comprising a device for increasing a blood pressure gradient across said fluid fractioning device. 4. The system of claim 3, wherein said device is a pump. 5. The system of claim 4, wherein said pump is a peristaltic pump. 6. The system of claim 1, further comprising a device for increasing a blood pressure gradient across said bone port. 7. The system of claim 1, wherein said fluid fractioning device includes at least one filter. 8. The system of claim 7, wherein said filter is impermeable to molecules above a predetermined size and permeable to water and solutes of said blood. 9. The system of claim 8, wherein said molecules are 10-500 kDa. 10. The system of claim 7, further comprising a mechanism for minimizing clogging of said filter. 11. The system of claim 10, wherein said mechanism is configured for creating an electrical field at or near said filter. 12. The system of claim 11, wherein said electrical field is an alternating current (AC) field. 13. The system of claim 1, wherein said bone port includes at least one elongated cylinder having a central bore. 14. The system of claim 1, wherein said return port is configured for returning said non-retained fraction of said blood to said bone marrow of said bone. 15. The system of claim 1, wherein said return port is fixatable to said bone or to another bone. 16. The system of claim 1, wherein said return port is configured to establish direct fluid communication with a blood vessel. 17. The system of claim 1, configured to allow flow reversibility between said bone port and said return port. 18. The system of claim 1, wherein said fluid fractioning device is configured for implantation between muscle and skin of the subject. 19. A method of filtering blood of a subject, the method comprising: communicating blood from a bone marrow of a bone of the subject to a fluid fractioning device capable of selectively fractioning blood flowing out of said bone marrow to thereby retain a fraction of said blood, said communication is effected via a bone port fixable to said bone, and, via a first fluid conduit connectable between said bone port and said fluid fractioning device and configured to establish fluid communication therebetween; andreturning a non-retained fraction of said blood to circulation of the subject, said returning is effected via a return port, and, via a second fluid conduit connectable between said fluid fractionating device and said return port and configured to establish fluid communication therebetween, thereby filtering blood thereof. 20. The method of claim 19, wherein said fraction of said blood includes water and solutes. 21. The method of claim 19, wherein said communicating is effected by implanting said bone port in said bone of the subject. 22. The method of claim 19, wherein said fluid fractioning device is implanted in soft tissue of a body of the subject. 23. The method of claim 19, wherein said fraction of said blood retained by said fluid fractioning device is routed to a bladder, a Genito-Urinary system or a reservoir via a fluid conduit positioned between said fluid fractioning device and said bladder, said Genito-Urinary system or said reservoir. 24. The method of claim 19, wherein the subject suffers from CKD, renal failure or congestive heart failure.
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