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[미국특허] Dual delivery system for heterologous antigens 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-001/20
  • C12N-015/74
  • A61K-039/39
  • A61K-039/00
  • C07K-014/515
  • C07K-014/47
  • A61K-038/19
출원번호 US-0341215 (2014-07-25)
등록번호 US-9650639 (2017-05-16)
발명자 / 주소
  • Maciag, Paulo
  • Wallecha, Anu
  • Shahabi, Vafa
출원인 / 주소
  • ADVAXIS, INC.
대리인 / 주소
    Alston & Bird LLP
인용정보 피인용 횟수 : 4  인용 특허 : 68

초록 ▼

Provided herein are recombinant Listeria strains expressing a tumor-specific antigenic polypeptide and, optionally, an angiogenic polypeptide wherein a nucleic acid molecule encoding at least one of the polypeptides is operably integrated into the Listeria genome in an open reading frame with a nucl

대표청구항 ▼

1. A recombinant Listeria strain comprising a first and second nucleic acid molecule, each said nucleic acid molecule encoding a heterologous antigenic polypeptide or immunogenic fragment thereof, wherein said first nucleic acid molecule is operably integrated into the Listeria genome in an open rea

이 특허에 인용된 특허 (68) 인용/피인용 타임라인 분석

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  14. Paterson, Yvonne; Peters, Christian; Gunn, George, Compositions and methods for enhancing the immunogenicity of antigens.
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  16. Paterson, Yvonne; Rothman, John, Compositions and methods for treatment of cervical cancer.
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  22. Paterson, Yvonne, Fusion of non-hemolytic, truncated form of listeriolysin O to antigens to enhance immunogenicity.
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  28. Karp, Nelson M., Immunizing compositions comprising recombinant attenuated self-replicating viral RNA replicons encoding an epitope obtained from the HIV-1 matrix protein myrstate binding site.
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  29. Karp, Nelson M., Immunizing compositions encoding an epitope obtained from the HIV-1 capsid protein cyclophilin A binding site.
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  30. Frankel Fred R. ; Portnoy Daniel A., Immunogenic compositions comprising DAL/DAT double-mutant, auxotrophic, attenuated strains of Listeria and their methods of use.
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  38. Frankel, Fred R., Isolated nucleic acids comprising Listeria dal and dat genes.
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  46. Paterson, Yvonne; Singh, Reshma, Methods and compositions for immunotherapy of cancer.
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  51. Frankel,Fred R.; Portnoy,Daniel A., Methods of inducing immune responses through the administration of auxtrophic attenuated dal/dat double mutant Listeria strains.
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  52. Collins, Mary; Wood, Clive R.; Carreno, Beatriz M.; Luxenberg, Deborah; Jussif, Jason; Carter, Laura L.; Bennett, Frances K.; Valge Archer, Viia; Andrews, John; Russell, Caroline, Methods of upmodulating adaptive immune response using anti-PD-1 antibodies.
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  53. Paterson, Yvonne; Maciag, Paulo Cesar, Non-hemolytic LLO fusion proteins and methods of utilizing same.
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  54. Jay M. Short, Non-stochastic generation of genetic vaccines.
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  55. Savitzky, Kinneret; Mintz, Liat; David, Anat; Azar, Idit, Nucleic acid and amino acid sequences.
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  56. Korman, Alan J.; Selby, Mark J.; Wang, Changyu; Srinivasan, Mohan; Passmore, David B.; Huang, Haichun; Chen, Haibin, Nucleic acids encoding monoclonal antibodies to programmed death ligand 1 (PD-L1).
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  57. Finnefrock, Adam C.; Fu, Tong-Ming; Freed, Daniel C.; Casimiro, Danilo R.; Li, Fengsheng; Tang, Aimin, PD-1 binding proteins.
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  59. Content Jean,BEX ; Huygen Kris,BEX ; Liu Margaret A. ; Montgomery Donna ; Ulmer Jeffrey, Polynucleotide tuberculosis vaccine.
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  65. Branstrom Arthur A. ; Sizemore Donata R. ; Sadoff Jerald C., Shigella vector for delivering DNA to a mammalian cell.
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  66. Portnoy,Daniel A.; Calendar,Richard; Lauer,Peter M., Site specificintegration vectors and methods for using the same.
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  67. Paterson Yvonne, Specific immunotherapy of cancer using a live recombinant bacterial vaccine vector.
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  68. Dubensky, Jr., Thomas W.; Brockstedt, Dirk G.; Cook, David N., attenuated for entry into non-phagocytic cells, vaccines comprising the , and methods of use thereof.
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이 특허를 인용한 특허 (4) 인용/피인용 타임라인 분석

  1. Petit, Robert, Biomarker directed multi-target immunotherapy.
    상세보기
  2. Rothman, John; Wallecha, Anu; Singh, Reshma; Harn, Jr., Donald A.; Paterson, Yvonne, Listeria-based adjuvants.
    상세보기
  3. Wallecha, Anu; Petit, Robert, Recombinant Listeria vaccine strains and methods of producing the same.
    상세보기
  4. Singh, Reshma; Wallecha, Anu, Suppressor cell function inhibition following Listeria vaccine treatment.
    상세보기

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