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Polymer conjugates of therapeutic peptides 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/00
  • A61K-047/48
  • A61K-038/10
  • A61K-038/16
  • A61K-038/28
출원번호 US-0664582 (2015-03-20)
등록번호 US-9682153 (2017-06-20)
발명자 / 주소
  • Bossard, Mary J.
  • Roczniak, Steven O.
  • Zappe, Harold
  • Wang, Yujun
  • Zhang, Ping
  • Sheng, Dawei
  • Jude-Fishburn, C. Simone
  • Minamitani, Elizabeth Louise
  • Liu, Xiaofeng
  • Moskowitz, Haim
  • Fry, Dennis G.
  • Ali, Cherie F.
  • Brew, Christine Taylor
출원인 / 주소
  • Nektar Therapeutics
인용정보 피인용 횟수 : 0  인용 특허 : 141

초록 ▼

The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attach

대표청구항 ▼

1. A conjugate having the structure: where: mPEG is CH3O—(CH2CH2O)nCH2CH2—;n is an integer from 10 to 1800;R1 is H or lower alkyl;R2 is H or lower alkyl;X1 and X2 are each independently —NH—C(O)—CH2—O—, —NH—C(O)—(CH2)q—O—, —NH—C(O)—(CH2)q—CO—NH—, —NH—C(O)—(CH2)q—, or —C(O)—NH—;q is 2, 3, 4, or 5;˜N

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