Microneedle injection apparatus comprising an inverted actuator
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
A61M-005/32
출원번호
US-0892238
(2014-05-22)
등록번호
US-9682222
(2017-06-20)
국제출원번호
PCT/US2014/039140
(2014-05-22)
국제공개번호
WO2014/193729
(2014-12-04)
발명자
/ 주소
Burton, Scott A.
Ng, Chin-Yee
Mathias, Richard R.
출원인 / 주소
3M INNOVATIVE PROPERTIES COMPANY
대리인 / 주소
3M Innovative Properties Company
인용정보
피인용 횟수 :
0인용 특허 :
25
초록▼
A microneedle injection apparatus (100) comprising an inverted actuator. The apparatus can include a housing (102) having a base and a cavity, and a microneedle array holder (106) configured to hold a microneedle array (107) within the cavity of the housing. The microneedle array holder can be movab
A microneedle injection apparatus (100) comprising an inverted actuator. The apparatus can include a housing (102) having a base and a cavity, and a microneedle array holder (106) configured to hold a microneedle array (107) within the cavity of the housing. The microneedle array holder can be movable between a retracted position, and an extended position. The apparatus can further include an actuator (104) movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position. At least a portion of the actuator can be located on a skin-facing side of the apparatus (e.g., adjacent the base of the housing) and can be configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface.
대표청구항▼
1. A microneedle injection apparatus comprising: a housing having a base and a cavity that extends through the base to define an opening in the base, wherein the base of the housing is configured to be positioned toward a skin surface;a microneedle array holder configured to hold a microneedle array
1. A microneedle injection apparatus comprising: a housing having a base and a cavity that extends through the base to define an opening in the base, wherein the base of the housing is configured to be positioned toward a skin surface;a microneedle array holder configured to hold a microneedle array within the cavity of the housing, the microneedle array holder configured to be at least partially located in the cavity of the housing and movable with respect to the opening in the base of the housing between a retracted position in which the microneedle array is recessed within the housing such that the microneedle array does not contact the skin surface when the base of the housing is positioned on the skin surface and the microneedle array is coupled to the microneedle array holder, andan extended position in which at least a portion of the microneedle array is positioned to contact the skin surface via the opening when the base of the housing is positioned on the skin surface and the microneedle array is coupled to the microneedle array holder; andan actuator movable with respect to the housing and the microneedle array holder between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position, wherein at least a portion of the actuator is located adjacent the base of the housing and is configured to be moved from the first position to the second position in response to the apparatus being pressed toward the skin surface,wherein the actuator is movable with respect to the base of the housing, wherein when the actuator is in the first position, an outermost surface of the actuator extends beyond the base of the housing by a first distance, andwhen the actuator is in the second position, the outermost surface of the actuator does not extend beyond the base of the housing, orextends beyond the base of the housing by a second distance that is less than the first distance, and whereinthe actuator is an inverted actuator having at least a portion of the actuator located on the same side of the housing as the base that is configured to be positioned towards a skin surface. 2. The apparatus of claim 1, wherein the actuator includes a base configured to be positioned toward the skin surface, wherein the microneedle array holder includes a base configured to be positioned toward the skin surface, wherein the base of the actuator is positioned a third distance from the base of the microneedle array holder when the actuator is in the first position, wherein the base of the actuator is positioned a fourth distance from the base of the microneedle array holder when the actuator is in the second position, and wherein the second distance is less than the first distance. 3. The apparatus of claim 1, wherein the actuator is located on a skin-facing side of the apparatus. 4. The apparatus of claim 1, wherein the apparatus has a footprint having a first area, and wherein the actuator has a footprint having a second area, and wherein the second area is less than half of the first area. 5. The apparatus of claim 1, further comprising a cartridge located within the housing, the cartridge defining a reservoir configured to contain an active agent, wherein the microneedle array holder is movable independently of the cartridge, and wherein movement of the actuator to the second position actuates both (i) movement of the microneedle array holder to the extended position and (ii) movement of the cartridge to the second position. 6. The apparatus of claim 1, wherein the plurality of microneedles are hollow, and further comprising a cartridge that includes a reservoir configured to contain an active agent, wherein the reservoir and at least some of the plurality of hollow microneedles are configured to be in fluid communication when the microneedle array is coupled to the microneedle array holder and the microneedle array holder is in the extended position, but not when the microneedle array holder is in the retracted position. 7. The apparatus of claim 1, wherein the microneedle array holder is held in the retracted position by a shuttle, and wherein the shuttle is movable between a first shuttle position in which the shuttle is positioned to hold the microneedle array holder in the retracted position and a second shuttle position in which the microneedle array holder is free to move to the extended position. 8. The apparatus of claim 1, wherein the actuator includes a base and an opening formed in the base, and wherein at least a portion of the microneedle array extends through the opening in the actuator and beyond the base of the actuator when the microneedle array holder is in the extended position. 9. The apparatus of claim 8, wherein the base of the actuator is configured to be coupled to the skin surface. 10. The apparatus of claim 1, wherein at least a portion of the actuator is located in the cavity of the housing and positioned to at least partially surround the microneedle array, at least when the microneedle array holder is in the extended position. 11. The apparatus of claim 1, wherein the actuator is configured to be held in the second position after being moved from the first position to the second position. 12. The apparatus of claim 1, further comprising: a biasing element positioned to bias the actuator in the first position, wherein the actuator is movable from the first position to the second position against the bias of the first biasing element; anda stored energy device operable to drive the microneedle array holder from the retracted position to the extended position as a result of the actuator being moved to the second position. 13. The apparatus of claim 1, wherein the actuator includes a skin-contact adhesive, and wherein the housing is configured to be coupled to the skin surface at least via the skin-contact adhesive on the actuator. 14. The apparatus of claim 1, wherein at least a portion of the actuator is located on a lower portion of the housing, wherein the actuator is configured to be moved from the first position to the second position in response to the apparatus being pressed toward a skin surface by pressing on an upper portion of the housing, and wherein the upper portion of the housing is located in an off-axis position with respect to an actuation axis of the actuator.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (25)
Sherman Faiz Feisal ; Yuzhakov Vadim Vladimirovich ; Gartstein Vladimir ; Owens Grover David, Apparatus and method for manufacturing an intracutaneous microneedle array.
Garbe James E. (Inver Grove Heights MN) Northey Paul J. (Somerset WI) Peterson Timothy A. (Lino Lakes MN), Method of making a pressure sensitive skin adhesive sheet material.
Srinivasan Venkateshwaran ; David Fikstad ; Charles D. Ebert, Method of making pressure sensitive adhesive matrix patches for transdermal drug delivery using hydrophilic salts of drugs and hydrophobic pressure sensitive adhesive dispersions.
Blizzard John D. (Bay City MI) Narula Dipak (Midland MI), Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-I.
Homan Gary R. (Midland MI) Vincent Harold L. (Midland MI), Silicone pressure-sensitive adhesive process and product with improved lap-shear stability-II.
Miranda Jesus (Miami FL) Sablotsky Steven (Miami FL), Solubility parameter based drug delivery system and method for altering drug saturation concentration.
Nelson Gregory R. (St. Paul MN) Zerbe Horst-Georg (St. Paul MN) Moore Cheryl L. (St. Paul MN) Wick Steven M. (St. Paul MN), Transdermal estradiol delivery system.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.