Antithrombogenic hollow fiber membranes and filters
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-001/36
B01D-063/02
A61L-033/06
F16L-011/04
B01D-067/00
B01D-069/02
B01D-069/08
B01D-071/44
B01D-071/68
B29C-047/00
B29L-023/00
B29L-031/00
출원번호
US-0132846
(2016-04-19)
등록번호
US-9687597
(2017-06-27)
발명자
/ 주소
Mullick, Sanjoy
Chang, Weilun
Chen, Hanje
Steedman, Mark A.
Esfand, Roseita
출원인 / 주소
Interface Biologies, Inc.
대리인 / 주소
Bieker-Brady, Kristina
인용정보
피인용 횟수 :
1인용 특허 :
40
초록▼
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofi
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
대표청구항▼
1. A blood tubing comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said blood tubing is antithrombogenic when contacted with blood, as measured by y-count, and wherein said surface modifying macromolecule is described by formula: FT—[B-(Oligo)]
1. A blood tubing comprising a base polymer admixed with from 0.005% to 10% (w/w) surface modifying macromolecule, wherein said blood tubing is antithrombogenic when contacted with blood, as measured by y-count, and wherein said surface modifying macromolecule is described by formula: FT—[B-(Oligo)]n-B—FT, (VII)wherein(i) Oligo is polypropylene oxide having a theoretical molecular weight of from 500 to 2,000 Daltons;(ii) B is a hard segment formed from hexamethylene diisocyanate;(iii) FT is a polyfluoroorgano group; and(iv) n is an integer from 1 to 10. 2. The blood tubing of claim 1, wherein said base polymer comprises polyvinyl chloride. 3. The blood tubing of claim 1, wherein n is an integer from 1 to 3. 4. The blood tubing of claim 1, wherein FT is a polyfluoroalkyl having a theoretical molecular weight of between 100-1,500 Da. 5. The blood tubing of claim 1, wherein FT is CF3(CF2)rCH2CH2—, wherein r is 2-20. 6. The blood tubing of claim 1, wherein FT is CF3(CF2)s(CH2CH2O)x—, wherein X is 1-10 and s is 1-20. 7. The blood tubing of claim 1, wherein FT is CHmF(3−m)(CF2)rCH2CH2— or CHmF(3−m)(CF2)s(CH2CH2O)x—, wherein m is 0, 1, 2, or 3; X is an integer between 1-10; r is an integer between 2-20; and s is an integer between 1-20. 8. The blood tubing of claim 1, wherein FT is formed from 1H,1H,2H,2H-perfluoro-1-decanol; 1H,1H,2H,2H-perfluoro-1-octanol; 1H,1H,5H-perfluoro-1-pentanol; or 1H,1H, perfluoro-1-butanol, or a mixture thereof. 9. The blood tubing of claim 8, wherein FT is formed from 1H,1H,2H,2H-perfluoro-1-octanol. 10. The blood tubing of claim 1, wherein FT is (CF3)(CF2)5CH2CH2O—, (CF3)(CF2)7CH2CH2O—, (CF3)(CF2)5CH2CH2O—, CHF2(CF2)3CH2O—, or (CF3)(CF2)2CH2O—. 11. The blood tubing of claim 1, wherein said surface modifying macromolecule is described by formula: wherein the [CH(CH3)CH2O]n unit has a theoretical molecular weight of from 500 to 2,000 Daltons. 12. The blood tubing of claim 11, wherein the [CH(CH3)CH2O]n unit has Mw of 1000 g/mol.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (40)
Hargis I. Glen (Tallmadge OH) Livigni Russell A. (Akron OH) Melby Earl G. (Uniontown OH) Vitus Francis J. (Tallmadge OH), Abrasion-resistant article coated with a coating compositions based on fluorinated monohydric alcohol.
Pietsch Hanns (Hamburg DEX) Kartheus Holger (Hamburg DEX) Holtzmann Hans-Joachim (Hamburg DEX) Sachau Gnther (Quickborn DEX) Reul Helmut (Dren DEX), Antithrombogenic, non-calcifying material and method of making articles for medical purposes.
Ward Robert S. (Lafayette CA) White Kathleen A. (Pleasant Hill CA), Copolymers and non-porous, semi-permeable membrane thereof and its use for permeating molecules of predetermined molecul.
Klun Thomas P. ; Gasper Alton J. ; Temperante John A., High temperature-stable fluorochemicals as hydrophobic and oleophobic additives to synthetic organic polymers.
Potts David C. (Dunwoody GA) Young George A. (Atlanta GA) Everhart Dennis S. (Alpharetta GA) MacDonald J. Gavin (Decatur GA) Nohr Ronald S. (Roswell GA), Multilayer nonwoven composite structure.
Potts David C. (Dunwoody GA) Young George A. (Atlanta GA) Everhart Dennis S. (Alpharetta GA) MacDonald J. Gavin (Decatur GA) Nohr Ronald S. (Roswell GA), Multilayer nonwoven laminiferous structure.
Kim Young H. (Seoul KRX) Han Dong K. (Seoul KRX), Perfluorocarbon-grafted polyurethane with improved blood compatibility and process for their preparation.
Sendijarevic Aisa ; Sendijarevic Vahid ; Frisch Kurt C. ; Cenens Jozef Lucien Rudolf,BEX ; Handlin ; Jr. Dale L. ; Chin Steven S. ; Hernandez Hector, Polyurethanes having improved moisture resistance.
Jennings James K. ; Jenkines Randall C. ; Mobley Larry W., Preparation of filled reactive polyurethane carpet backing formulations using an in-line continuous mixing process.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.