[미국특허]
Compositions containing water-soluble derivatives of vitamin E mixtures and modified food starch
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23L-001/30
A23L-001/0522
A23L-002/52
A23L-029/212
A23L-033/12
A23L-033/15
출원번호
US-0449880
(2014-08-01)
등록번호
US-9693574
(2017-07-04)
발명자
/ 주소
Bromley, Philip J.
출원인 / 주소
Virun, Inc.
대리인 / 주소
Dentons US LLP
인용정보
피인용 횟수 :
2인용 특허 :
54
초록▼
Provided are compositions that contain a modified food starch and one or more non-polar compounds. In some instances, the compositions contain a water-soluble derivative of vitamin E mixture, containing relatively high concentrations of dimer forms of the PEG-derivative of vitamin E. Compositions in
Provided are compositions that contain a modified food starch and one or more non-polar compounds. In some instances, the compositions contain a water-soluble derivative of vitamin E mixture, containing relatively high concentrations of dimer forms of the PEG-derivative of vitamin E. Compositions include concentrates, dilution compositions and compositions for direct consumption. Methods for preparing the compositions also are provided.
대표청구항▼
1. A composition, comprising: a) a modified food starch in an amount between about 1% and about 70%, by weight, of the composition;b) a water-soluble vitamin E derivative mixture present in an amount from 1% to 98%, inclusive, by weight, of the composition, wherein: the water-soluble vitamin E deriv
1. A composition, comprising: a) a modified food starch in an amount between about 1% and about 70%, by weight, of the composition;b) a water-soluble vitamin E derivative mixture present in an amount from 1% to 98%, inclusive, by weight, of the composition, wherein: the water-soluble vitamin E derivative mixture comprises: at least 13 wt % of a water-soluble vitamin E derivative dimer; andup to 87%, by weight, of a water-soluble vitamin E derivative monomer;wherein the water-soluble vitamin E derivative dimer is a polyethylene glycol (PEG) derivative of vitamin E; andc) a non-polar compound or a mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture. 2. The composition of claim 1, wherein the water soluble vitamin E derivative mixture comprises between about 35 weight % and about 55 weight % of the water-soluble vitamin E derivative dimer. 3. The composition of claim 1, further comprises a polar solvent in an amount between about 1% and about 95%, by weight, of the composition. 4. The composition of claim 3, wherein the polar solvent is present in an amount up to about 80%, by weight, of the composition. 5. The composition of claim 1, wherein the composition is for direct consumption. 6. The composition of claim 1, wherein the composition is a concentrate. 7. The composition of claim 6, wherein the composition is an emulsion concentrate. 8. The composition of claim 4, wherein the amount of the non-polar compound or the mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture is between about 0.001% and about 25%, by weight, of the composition. 9. The composition of claim 1, wherein the modified food starch is in an amount between about 1% and about 30%, by weight, of the composition. 10. The composition of claim 1, wherein the water soluble vitamin E derivative mixture is in an amount between about 1% and about 35%, by weight, of the composition. 11. The composition of claim 3, wherein the polar solvent is present in an amount between about 55% and about 90%, by weight, of the composition. 12. The composition of claim 9, wherein the modified food starch in an amount between about 2% and about 25%, by weight, of the composition. 13. The composition of claim 1, further is an emulsion concentrate, comprising: the modified food starch is in an amount between about 5% and about 25%, by weight, of the composition;the water soluble-vitamin E derivative mixture is in an amount between about 1% and about 30%, by weight, of the composition; andwherein the non-polar compound or the mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture, is one or more non-polar compounds in an amount between about 5% and about 30%, by weight, of the composition. 14. The composition of claim 1, wherein the water soluble vitamin E derivative mixture is: tocopheryl polyethylene glycol succinate (TPGS), tocopheryl sebacate polyethylene glycol, tocopheryl dodecanodioate polyethylene glycol, tocopheryl suberate polyethylene glycol, tocopheryl azelaate polyethylene glycol, tocopheryl citraconate polyethylene glycol, tocopheryl methylcitraconate polyethylene glycol, tocopheryl itaconate polyethylene glycol, tocopheryl maleate polyethylene glycol, tocopheryl glutarate polyethylene glycol, tocopheryl glutaconate polyethylene glycol and tocopheryl phthalate polyethylene glycol, TPGS analogs or TPGS homologs. 15. The composition of claim 14, wherein the water soluble vitamin E derivative mixture is α-tocopheryl polyethylene glycol succinate (TPGS). 16. The composition of claim 15, wherein the water soluble vitamin E derivative mixture is α-tocopheryl polyethylene glycol succinate 1000. 17. The composition of claim 9, wherein the modified food starch is: a modified corn, potato, wheat, rice, tapioca, sago, oat, barley, amaranth, waxy corn, cassava, waxy barley, waxy rice, glutinous rice or sweet rice starch. 18. A food or beverage, comprising the composition of claim 1. 19. The composition of claim 1, wherein the water soluble vitamin E derivative mixture is present in an amount between about 5% and about 15%, by weight, of the composition. 20. The composition of claim 1, wherein the modified food starch is: a modified corn, potato, wheat, rice, tapioca, sago, oat, barley, amaranth, waxy corn, cassava, waxy barley, waxy rice, glutinous rice or sweet rice starch. 21. The composition of claim 1, wherein the modified food starch is an octenyl succinate starch that is: a sodium octenyl succinate starch, calcium octenyl succinate starch or aluminum octenyl succinate starch. 22. The composition of claim 1, wherein the modified food starch is a sodium octenyl succinate waxy corn starch. 23. The composition of claim 1, wherein the non-polar compound or the mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture, comprise: polyunsaturated fatty acids, coenzyme Q-containing active ingredients, oil soluble vitamins other than a vitamin E, alpha lipoic acid, medium chain triglycerides, a cannabinoid or carotenoid-containing active ingredients and phytochemicals. 24. The composition of claim 23, wherein the polyunsaturated fatty acids are: omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, pyrroloquinoline quinines, beta caryophyllenes (BCP) or mixtures thereof. 25. The composition of claim 23, wherein the polyunsaturated fatty acids are: docosahexaenoic acids (DHA), eicosapentaenoic acids (EPA), fish oils, flaxseed oils, borage oils, alpha-linolenic acids (ALA), gamma-linolenic acids (GLA), conjugated linoleic acids (CLA), or saw palmetto extracts. 26. The composition of claim 19, wherein the water soluble vitamin E derivative mixture is tocopheryl polyethylene glycol succinate (TPGS). 27. The composition of claim 1, further comprising a solvent, wherein the solvent is: water, glycerin, propylene glycol, ethylene glycol, tetraethylene glycol, triethylene glycol or trimethylene glycol. 28. The composition of claim 1, further comprising a preservative in an amount between about 0.1% and about 1%, by weight, of the composition. 29. The composition of claim 28, wherein the preservative is benzyl alcohol. 30. A method for preparing the composition of claim 1, a liquid emulsion concentrate, comprising: (a) generating a water phase by: (i) heating a polar solvent in a first vessel;(ii) adding one or more water phase ingredients; and(iii) mixing until combined;(b) generating an oil phase by: (i) heating the water-soluble vitamin E derivative mixture and a preservative in a second vessel, wherein: the water-soluble vitamin E derivative mixture is a high dimer and present in an amount between 2% or about 2% and 10% or about 10%, by weight, of the liquid emulsion concentrate; and the water-soluble vitamin E derivative mixture is a polyethylene glycol (PEG) derivative of vitamin E;(ii) adding one or more oil phase ingredients, wherein the oil phase ingredients comprise the non-polar compound or the mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture in an amount between 5% or about 5% and 30% or about 30%, by weight, of the liquid emulsion concentrate; and(iii) mixing until combined; and(c) emulsifying the oil phase and the water phase, thereby generating the liquid emulsion concentrate;wherein the one or more oil phase ingredients or the one or more water phase ingredients, contain a modified food starch in an amount between about 8% and about 20%, by weight, of the liquid emulsion concentrate. 31. A method for preparing the composition of claim 1, a liquid emulsion concentrate, comprising: (a) generating a water phase by: (i) heating a polar solvent in a first vessel, wherein the polar solvent is present in an amount between about 55% and about 80%, by weight, of the concentrate;(ii) adding one or more water phase ingredients; and(iii) mixing until combined;(b) generating an oil phase by heating one or more oil phase ingredients, wherein the oil phase ingredients comprise the non-polar compound or the mixture of non-polar compounds in an amount between about 5% and about 20%, by weight, of the liquid emulsion concentrate, wherein the non-polar compound or the mixture of non-polar compounds are: polyunsaturated fatty acids, omega-3 fatty acids, omega-6 fatty acids, omega-9 fatty acids, conjugated fatty acids, coenzyme Q-containing active ingredients, oil soluble vitamins other than a vitamin E, alpha lipoic acid, medium chain triglycerides, cannabinoid or carotenoid-containing active ingredients, or phytochemicals; and(c) emulsifying the oil phase and the water phase, thereby generating the liquid emulsion concentrate;wherein the one or more oil phase ingredients or the one or more water phase ingredients, contain a modified food starch in an amount between about 15% and about 25%, by weight, of the concentrate. 32. A lyophilized or spray dried powder produced by lyophilizing or spray drying the composition of claim 1, a liquid emulsion concentrate. 33. A container, comprising a beverage composition comprising the composition of claim 1, wherein the container is sealed and comprises nitrogen as a preservative, wherein the nitrogen replaces air in the container. 34. The container of claim 33, wherein the container is a bottle or an ampoule. 35. A container, comprising a beverage composition comprising the composition of claim 27, wherein the container is sealed and comprises nitrogen as a preservative, wherein the nitrogen replaces air in the container. 36. The container of claim 35, wherein the container is a bottle or an ampoule. 37. The composition of claim 19, wherein the water soluble-vitamin E derivative mixture is a high dimer-containing the water soluble vitamin E derivative mixture comprising: between 29 weight % of a PEG-derivative of vitamin E dimer and up to 69 weight % of PEG-derivative of vitamin E dimer. 38. The composition of claim 1, further comprising a pH adjuster in an amount less than 5% or about 5%, by weight, of the composition. 39. The composition of claim 1, wherein the non-polar compound or the mixture of non-polar compounds other than the water-soluble vitamin E derivative mixture, comprise polyunsaturated fatty acids, coenzyme Q-containing active ingredients, oil soluble vitamins other than a vitamin E, alpha lipoic acid, medium chain triglycerides, a cannabinoid or carotenoid-containing active ingredients, phytochemicals, or mixtures thereof. 40. The composition of claim 39, wherein the non-polar compounds other than the water-soluble vitamin E derivative mixture are: polyunsaturated fatty acids; wherein the polyunsaturated fatty acids are: selected from among omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, pyrroloquinoline quinine, beta-caryophyllene (BCP) or mixtures thereof. 41. The composition of claim 1, wherein the water-soluble vitamin E derivative mixture contains 29%-69%, inclusive, of a dimer, by weight of the water-soluble vitamin E derivative mixture.
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