Compositions (3) and methods of using such compositions (3) to condition, clean, or disinfect the flow path of a conduit (8) of a microfluidic devices (16), such as flow cytometers or liquid chromatographs.
대표청구항▼
1. An antimicrobial composition, comprising: an alcohol about 10% to about 55% by volume selected from the group consisting of methanol, ethanol, N-propanol, isopropanol, 2-butanol, n-butanol and isobutanol;a ketone about 2% to about 10% by volume selected from the group consisting of acetone, 2-but
1. An antimicrobial composition, comprising: an alcohol about 10% to about 55% by volume selected from the group consisting of methanol, ethanol, N-propanol, isopropanol, 2-butanol, n-butanol and isobutanol;a ketone about 2% to about 10% by volume selected from the group consisting of acetone, 2-butanone, cyclohexanone, 2-pentanone, 3-pentanone, 2-hexanone, 3-hexanone, methyl isobutyl ketone, cyclobutanone, and cyclopentanone, said alcohol and said ketone being the only effective antimicrobially active components in said antimicrobial composition; andan inactive agent comprising water, wherein said alcohol and said ketone remain miscible in said water, and wherein said alcohol and said ketone combined in amounts which kill viable microorganisms by greater than 2-log10 within a time period of about five minutes to about thirty minutes. 2. The antimicrobial composition of claim 1, wherein said alcohol comprises about 30% to about 50% by volume, and wherein said ketone comprises about 2% to about 10% by volume. 3. The antimicrobial composition of claim 1, wherein said composition is selected from the group consisting of: methanol 50%, acetone 10%, and water 40% v/v; methanol 50%, 2-butanone 10%, and water 40% v/v; methanol 50%, cyclohexanone 10%, and water 40% v/v; ethanol 50%, acetone 10%, and water 40% v/v; ethanol 50%, 2-butanone 10%, and water 40% v/v; ethanol 50%, cyclohexanone 10%, and water 40% v/v; isopropanol 50%, acetone 10%, and water 40% v/v; isopropanol 50%, 2-butanone 10%, and water 40% v/v; isopropanol 50%, cyclohexanone 10%, and water 40% v/v; N-propanol 50%, acetone 10%, and water 40% v/v; N-propanol 50%, 2-butanone 10%, and water 40% v/v; N-propanol 50%, cyclohexanone 10%, and water 40% v/v; 2-butanol 50%, acetone 10%, and water 40% v/v; 2-butanol 50%, 2-butanone 10%, and water 40% v/v; and 2-butanol 50%, cyclohexanone 10%, and water 40% v/v. 4. The antimicrobial composition of claim 1, wherein said alcohol and said ketone comprise isopropanol 50% and acetone 10% by volume. 5. The antimicrobial composition of claim 1, wherein said viable microorganisms occur within a flow path of a microfluidic instrument, said antimicrobial composition has a flow within said flow path of said microfluidic instrument to kill said viable microorganisms within said flow path by greater than 2-log10 within said time period of about five minutes to about thirty minutes. 6. The antimicrobial composition of claim 5, wherein said flow of said antimicrobial composition in said flow path of said microfluidic device generated by an amount of pressure exerted on the external surface of a variable volume container containing said antimicrobial composition. 7. The antimicrobial composition of claim 6, wherein said flow of said antimicrobial composition in said flow path of a microfluidic device occurs in a flow cytometer.
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이 특허에 인용된 특허 (29)
Contaxis ; III William ; Slovak Robert A., Additive dispensing apparatus.
Krasnoff Eric J. (Old Brookville NY) Bormann Thomas J. (Melville NY) Gsell Thomas C. (Glen Cove NY) Pascale Frank R. (Glen Cove NY) Matkovich Vlado I. (Glen Cove NY), Automated system for processing biological fluid.
Robert Jean-Edouard (Neuilly sur Seine FRX) Le Comte Roger (Carnon FRX) Champseix Henri (Montferrier S/Lez FRX), Automatic connection box for distributing reagents in a haematological analyzer.
Pomeroy Patrick C. (1920 Gilly La. Concord CA 94518) Madsen Randall (8970 Taurus Pl. San Diego CA 92126) Chan Wai P. (18845 California St. Castro Valley CA 94546) Lemke Gary (1630 St. David Dr. Danvi, Method and apparatus for post-transfer assaying of material on solid support.
Driggers Terry L. (505 Dance Dr. West Columbia TX 77486) Holemans Peter (Wallingford PA) Smith W. Novis (Philadelphia PA), Sprayable composition using acetone solvent.
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