[특허]Templated nanoconjugates

[미국특허] Templated nanoconjugates 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-049/00 A61K-047/48 B82Y-005/00 B82Y-015/00 C12N-015/88 G01N-033/58 A61K-051/12 C12Q-001/68
출원번호	US-0865848 (2015-09-25)
등록번호	US-9757475 (2017-09-12)
발명자 / 주소	Mirkin, Chad A. Giljohann, David A. Daniel, Weston L. Cutler, Joshua I. Zhang, Ke Zheng, Dan
출원인 / 주소	NORTHWESTERN UNIVERSITY
대리인 / 주소	Marshall, Gerstein & Borun LLP
인용정보	피인용 횟수 : 0 인용 특허 : 220

초록

The present disclosure is directed to compositions comprising templated nanoconjugates and methods of their use.

대표청구항 ▼

1. A nanoconjugate having a defined structure and comprising a plurality of crosslinked biomolecules crosslinked to each other in a monolayer, said structure defined by a surface providing a template upon which the structure is assembled. 2. The nanoconjugate of claim 1 wherein the surface is a nanoparticle. 3. The nanoconjugate of claim 2 wherein the nanoparticle is selected from the group consisting of a sphere, a rod and a prism. 4. The nanoconjugate of claim 3 wherein the nanoparticle is metallic. 5. The nanoconjugate of claim 4 wherein the nanoparticle is a colloidal metal. 6. The nanoconjugate of claim 5 wherein the nanoparticle is selected from the group consisting of a gold nanoparticle, a silver nanoparticle, a platinum nanoparticle, an aluminum nanoparticle, a palladium nanoparticle, a copper nanoparticle, a cobalt nanoparticle, an indium nanoparticle, and a nickel nanoparticle. 7. The nanoconjugate of claim 1 wherein each biomolecule in the plurality of biomolecules is the same. 8. The nanoconjugate of claim 1 wherein at least two of the biomolecules in the plurality of biomolecules are different. 9. The nanoconjugate of claim 1 wherein the biomolecule is selected from the group consisting of a polynucleotide, peptide, polypeptide, phospholipid, oligosaccharide, small molecule, therapeutic agent, contrast agent and combinations thereof. 10. The nanoconjugate of claim 1 wherein the biomolecule is a polynucleotide. 11. The nanoconjugate of claim 10 wherein the polynucleotide is DNA or RNA. 12. The nanoconjugate of claim 11 wherein the RNA is a small interfering RNA (siRNA). 13. The nanoconjugate of claim 1 wherein the plurality of biomolecules is monodisperse. 14. The nanoconjugate of claim 13 wherein the monodispersity is such that there is about 25% variation in the diameter of a plurality of nanoconjugates. 15. The nanoconjugate of claim 13 wherein the monodispersity is such that there is about 10% variation in the diameter of a plurality of nanoconjugates. 16. The nanoconjugate of claim 13 wherein the monodispersity is such that there is about 1% variation in the diameter of a plurality of nanoconjugates. 17. The nanoconjugate of claim 1 wherein density of crosslinked biomolecules on the surface is sufficient for cooperative behavior between the biomolecules. 18. The nanoconjugate of claim 17 wherein density of crosslinked biomolecules on the surface is at least 2 pmol/cm2. 19. The nanoconjugate of claim 17 wherein density of crosslinked biomolecules on the surface is at least 15 pmol/cm2. 20. The nanoconjugate of claim 1 wherein the nanoconjugate further comprises an additional agent selected from the group consisting of a polynucleotide, peptide, polypeptide, phospholipid, oligosaccharide, metal complex, small molecule, therapeutic agent, contrast agent and combinations thereof. 21. The nanoconjugate of claim 20 wherein the additional agent is associated with at least one biomolecule of the plurality of biomolecules through hybridization. 22. The nanoconjugate of claim 20 wherein the additional agent is covalently associated with at least one biomolecule of the plurality of biomolecules. 23. The nanoconjugate of claim 20 wherein the additional agent is entrapped in the crosslinked biomolecules of the nanoconjugate. 24. The nanoconjugate of claim 1 wherein the surface is removed and the nanoconjugate is hollow in the absence of the surface. 25. The nanoconjugate of claim 24 wherein an additional agent is encapsulated in the nanoconjugate which is otherwise hollow. 26. A method of detecting a target molecule comprising contacting the target molecule with the nanoconjugate of claim 1, wherein contact between the target molecule and the composition results in a detectable change. 27. The method of claim 26 wherein the detecting is in vitro. 28. The method of claim 26 wherein the detecting is in vivo. 29. A method of inhibiting expression of a gene product encoded by a target polynucleotide comprising contacting the target polynucleotide with the nanoconjugate of claim 1 under conditions sufficient to inhibit expression of the gene product. 30. The method of claim 29 wherein expression of the gene product is inhibited in vivo. 31. The method of claim 29 wherein expression of the gene product is inhibited in vitro. 32. The method of claim 29 wherein expression of the gene product is inhibited by at least about 5%. 33. The nanoconjugate of claim 5 wherein the nanoparticle is a gold nanoparticle. 34. The nanoconjugate of claim 33 wherein each biomolecule comprises an alkyne moiety. 35. The nanoconjugate of claim 3 wherein the nanoparticle is organic.

이 특허에 인용된 특허 (220) 인용/피인용 타임라인 분석

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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Mirkin, Chad A.; Letsinger, Robert L.; Mucic, Robert C.; Storhoff, James J.; Elghanian, Robert; Taton, Thomas A., Nanoparticles having oligonucleotides attached thereto and uses therefor.
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Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
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Tullis Richard H. (Leucadia CA), Novel amphiphilic nucleic acid conjugates.
상세보기
Nguyen Thanh T. (Tigy FRX) Helene Claude (Saint Cyr en Val FRX) Asseline Ulysse (La Source FRX), Novel compounds containing an oligonucleotide sequence bonded to an intercalating agent, a process for their synthesis a.
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Weis Alexander L. (Berwyn PA) Oakes Fred T. (Rochester NY) Hausheer Frederick H. (San Antonio TX) Cavanaugh ; Jr. Paul F. (West Chester PA) Moskwa Patricia S. (Phoenixville PA), Nuclease resistant compounds.
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Cook Philip D. (Carlsbad CA) Sanghvi Yogesh S. (San Marcos CA), Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression.
상세보기
Swaminathan Sundaramoorthi ; Matteucci Mark ; Jones Robert J. ; Pudlo Jeff ; Munger John, Nuclease stable and binding competent oligomers and methods for their use.
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Walder Joseph A. (Iowa City IA) Walder Roxanne Y. (Iowa City IA), Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled.
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Bischofberger Norbert W. (San Carlos CA) Matteucci Mark D. (Burlingame CA), Nucleic acid intercalating agents.
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Gold, Larry; Drolet, Daniel; Zichi, Dominic A.; Jayasena, Sumedha; Creighton, Steve; Gill, Stanley, Nucleic acid ligand diagnostic biochip.
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Ramachandran Kuzhalmannam L. (Natick MA) Cate Richard L. (Plymouth MA), Nucleic acid probe linked to a label having a terminal cysteine.
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Hogan James (San Diego CA) Smith Richard (San Diego CA) Kop Joann (San Marcos CA), Nucleic acid probes for detection and/or quantitation of non-viral organisms.
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Rokita Steven E. (Port Jefferson NY) Chatterjee Moneesh (Stony Brook NY), Nucleic acids labeled with naphthoquinone probe.
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Buhr Chris (Daly City CA) Matteucci Mark (Burlingame CA) Bischofberger Norbert W. (San Carlos CA) Froehler Brian (Belmont CA), Nucleoside 5′-methylene phosphonates.
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Haralambidis Jim (Victoria AUX), Nucleoside derivatives.
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Froehler Brian C. (Belmont CA) Buhr Chris A. (Daly City CA), Nucleoside hydrogen phosphonodithioate diesters and activated phosphonodithioate analogues.
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Klevan Leonard (Washington DC) Gebeyehu Gulilat (Silver Spring MD) Rao Prasad Y. (Damascus MD), Nucleotide analogs for nucleic acid labeling and detection.
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Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Nucleotides for introducing selectably cleavable and/or abasic sites into oligonucleotides.
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Meyer ; Jr. Rich B. (Woodinville WA) Adams A. David (Snohomish WA) Petrie Charles R. (Woodinville WA), Oligo (aa 상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

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[미국특허] Templated nanoconjugates 원문보기

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