최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0085749 (2013-11-20) |
등록번호 | US-9764093 (2017-09-19) |
발명자 / 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 621 |
A method and apparatus for plasma modifying a workpiece such as a syringe barrel, cartridge barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magne
A method and apparatus for plasma modifying a workpiece such as a syringe barrel, cartridge barrel, vial, or blood tube is described. Plasma is provided within the lumen of the workpiece. The plasma is provided under conditions effective for plasma modification of a surface of the workpiece. A magnetic field is provided in at least a portion of the lumen. The magnetic field has an orientation and field strength effective to improve the uniformity of plasma modification of the interior surface of the generally cylindrical wall. A vessel made according to the process or using the apparatus described above. A pharmaceutical package comprising the syringe barrel or vial containing a pharmaceutical preparation, secured with a closure.
1. A method of plasma modifying a syringe barrel or cartridge barrel having a surface to be treated, the method comprising: providing plasma in or near the surface under conditions effective for plasma modification of the surface of the syringe barrel or cartridge barrel further comprising generatin
1. A method of plasma modifying a syringe barrel or cartridge barrel having a surface to be treated, the method comprising: providing plasma in or near the surface under conditions effective for plasma modification of the surface of the syringe barrel or cartridge barrel further comprising generating the plasma by providing an outer electrode outside the barrel and an inner electrode at least partially inside the lumen of the barrel and energizing the electrodes using radiofrequency energy; andat least part of the time while providing plasma, providing a magnetic field in or near the plasma, the magnetic field having a position, orientation, and field strength effective to improve the uniformity, density, or both of plasma modification of the surface of the syringe barrel or cartridge barrel, in which the uniformity of plasma modification is expressed as a ratio of: one standard deviation of coating thickness/mean coating thickness and the ratio is from 0.5 to 0.2. 2. The method of claim 1, in which the surface is a generally cylindrical interior surface defining at least a portion of a lumen. 3. The method of claim 1, in which the magnetic field is provided by providing at least one magnetic field generator near the surface, each magnetic field generator having a north pole and a south pole defining a polar axis, in which at least part of the time while providing the magnetic field, at least one magnetic field generator has its polar axis generally parallel to the axis of the surface. 4. The method of claim 3, in which at least part of the time while providing the magnetic field, at least two magnetic field generators are circumferentially distributed around the surface. 5. The method of claim 3, in which at least two of the magnetic field generators are rotated about the surface, or the surface rotates with respect to the magnetic field generators, or both, during at least a portion of the plasma treatment. 6. The method of claim 3, in which at least one magnetic field generator is a permanent magnet. 7. The method of claim 3, further comprising at least part of the time while providing the magnetic field, translating at least one of the magnetic field generators axially along the surface, or translating the surface with respect to the magnetic field generator, or both, at a rate effective to improve the uniformity of barrel heating along the axis of the surface. 8. The method of claim 1, in which the barrel is a syringe body and needle assembly, the assembly having a needle end, a back end, and a body portion between the ends. 9. The method of claim 1, in which at least part of the time while providing the magnetic field, at least a portion of the magnetic field in at least a portion of the lumen is oriented with its polar axis extending generally in radial planes with respect to the surface. 10. A method of plasma modifying a syringe barrel or cartridge barrel having a surface to be treated, the method comprising: providing plasma in or near the surface under conditions effective for plasma modification of the surface of the syringe barrel or cartridge barrel; andat least part of the time while providing plasma, providing a magnetic field in or near the plasma by providing at least one magnetic field generator near the surface, each magnetic field generator having a north pole and a south pole defining a polar axis, the magnetic field having a position, orientation, and field strength effective to improve the uniformity, density, or both of plasma modification of the surface of the syringe barrel or cartridge barrel, in which the uniformity of plasma modification is expressed as a ratio of:one standard deviation of coating thickness/mean coating thickness and the ratio is from 0.5 to 0.2 in which at least part of the time while providing the magnetic field, an even number of at least four magnetic field generators are arranged about the axis to provide a quadrupole or analogous structure between axially spaced ends, and at least part of the time while providing the magnetic field, at least one magnetic field generator has its polar axis generally parallel to the axis of the surface. 11. The method of claim 10, further comprising generating the plasma by providing an outer electrode outside the barrel and an inner electrode at least partially inside the lumen of the barrel and energizing the electrodes using radiofrequency energy. 12. The method of claim 1, in which the plasma modification of the surface comprises plasma enhanced chemical vapor deposition (PECVD). 13. The method of claim 12, further comprising an inner electrode at least partially inside the lumen of the barrel, in which the inner electrode comprises a material supply tube having a generally cylindrical wall disposed within the lumen for providing gaseous material to the lumen. 14. A method of plasma modifying a syringe barrel or cartridge barrel having a surface to be treated, the method comprising: providing plasma in or near the surface under conditions effective for plasma modification via plasma enhanced chemical vapor deposition (PECVD) of the surface of the syringe barrel or cartridge barrel; andat least part of the time while providing plasma, providing a magnetic field in or near the plasma, the magnetic field having a position, orientation, and field strength effective to improve the uniformity, density, or both of plasma modification of the surface of the syringe barrel or cartridge barrel, in which the uniformity of plasma modification is expressed as a ratio of: one standard deviation of coating thickness/mean coating thickness and the ratio is from 0.5 to 0.2;wherein the plasma is generated by providing an outer electrode outside the barrel and an inner electrode at least partially inside the lumen of the barrel and the inner electrode comprises a material supply tube having a generally cylindrical wall disposed within the lumen for providing gaseous material to the lumen;and wherein the plasma process conditions are controlled such that the distance between the inlet tube and the wall of the syringe barrel or other part undergoing PECVD is at least 2 times as great as the Debye Length. 15. The method of claim 1, in which the plasma modification is carried out at least in part at a subatmospheric pressure, in which the subatmospheric pressure is generated by at least partially evacuating a lumen at or near the surface, while the exterior of the barrel is exposed to atmospheric pressure during at least a portion of the plasma modification. 16. The method of claim 1, in which the material supplied to the lumen during at least a portion of the plasma modification comprises: an organosiloxane precursor;optionally an oxidizing gas; andoptionally a diluent gas. 17. The method of claim 16, in which the precursor comprises hexamethylenedisiloxane hexamethyldisiloxane (HMDSO), octamethylcyclotetrasiloxane (OMCTS), or a combination of these. 18. The method of claim 1, in which the plasma modification comprises application of a barrier coating to the surface of the barrel. 19. The method of claim 18, in which the barrier coating consists essentially of SiOx, in which x is from 1.5 to 2.9. 20. The method of claim 18, in which the plasma modification comprises application of a pH protective coating to the surface of the barrel, in which the pH protective coating consists essentially of SiOxCy, in which x is from about 0.5 to about 2.4 and y is from about 0.6 to about 3. 21. The method of claim 1, in which the plasma modification is application of a coating having a mean thickness from 190 to 10 nm. 22. The method of claim 1, further comprising measuring plasma characteristics using at least one of: a camera configured to show whether the plasma comprises streamers of non-uniform plasma versus complete fill with uniform plasma,an optical emissions spectrometer to determine the uniformity of the plasma spectrum;a Rogowski Coil disposed about the inner electrode or its power supply conductor to determine the uniformity of the current supplied to the plasma; ora Langmuir probe to measure the electron temperature of the plasma. 23. The method of claim 14, in which the material supply tube has perforations distributed axially and circumferentially along the generally cylindrical wall to pass gaseous material to the lumen. 24. The method of claim 1, in which the aspect ratio between the inside diameter and length of the vessel being plasma treated is at least 3:1.
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