Eosinophil peroxidase compositions and methods of their use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/44
A61K-045/06
A61K-031/198
A61K-031/327
A61K-031/401
A61K-033/40
출원번호
US-0150619
(2014-01-08)
등록번호
US-9782459
(2017-10-10)
발명자
/ 주소
Stephens, Jr., Jackson T.
Pete, Matthew J.
출원인 / 주소
EXOXEMIS, INC.
대리인 / 주소
K&L Gates LLP
인용정보
피인용 횟수 :
0인용 특허 :
19
초록
Eosinophil peroxidase compositions and methods of their use for killing and/or inhibiting the growth of susceptible microorganisms are provided. The compositions include an eosinophil peroxidase, a peroxide or peroxide source, and amino acids glycine, L-alanine, and L-proline.
대표청구항▼
1. A composition for killing or inhibiting the growth of non-sporular bacteria, comprising: (a) an eosinophil peroxidase;(b) glucose oxidase; and(c) amino acids glycine, L-alanine, and L-proline, wherein the amino acids enhance the antibacterial activity of the eosinophil peroxidase. 2. The composit
1. A composition for killing or inhibiting the growth of non-sporular bacteria, comprising: (a) an eosinophil peroxidase;(b) glucose oxidase; and(c) amino acids glycine, L-alanine, and L-proline, wherein the amino acids enhance the antibacterial activity of the eosinophil peroxidase. 2. The composition of claim 1, further comprising a bromide. 3. The composition of claim 1, comprising from about 0.1 to about 1,000 μg/ml of eosinophil peroxidase. 4. The composition of claim 1, comprising from about 0.1 to about 500 mM of each amino acid. 5. The composition of claim 1, comprising from about 1 to about 500 U/ml of glucose oxidase. 6. A method for killing or inhibiting the growth of non-sporular bacteria comprising, contacting the non-sporular bacteria with an effective amount of a composition of claim 1. 7. A method of treating a non-sporular bacterial infection in a human or animal subject, comprising administering to the site of infection an effective amount of a composition of claim 1. 8. A method of treating a non-sporular bacterial infection of a surgical site in a human or animal subject, comprising administering to the surgical site an effective amount of a composition of claim 1. 9. The method of claim 8, wherein the surgical site is a cancer surgical site. 10. The method of claim 9, wherein the cancer surgical site is a colorectal cancer surgical site. 11. The method of claim 9, wherein the cancer surgical site is a brain cancer surgical site. 12. The method of claim 8, wherein the surgical site is a laparoscopic surgical site. 13. The method of claim 7, wherein the non-sporular bacterial infection is a multidrug resistant infection. 14. A binary combination for killing or inhibiting the growth of non-sporular bacteria, comprising: (a) a first composition comprising an eosinophil peroxidase; glucose oxidase; and amino acids glycine, L-alanine, and L-proline, wherein the amino acids enhance the antibacterial activity of the eosinophil peroxidase; and(b) a second composition comprising glucose,wherein the binary combination is effective for killing or inhibiting the growth of non-sporular bacteria when the first composition and the second composition are combined in a single solution and come in contact with the non-sporular bacteria. 15. The binary combination of claim 14, wherein the first composition, the second composition, or both the first composition and the second composition further comprise a bromide. 16. A binary combination for killing or inhibiting the growth of non-sporular bacteria, comprising: (a) a first composition comprising an eosinophil peroxidase; glucose oxidase; and amino acids glycine, L-alanine, and L-proline, wherein the amino acids enhance the antibacterial activity of the eosinophil peroxidase; and(b) a second composition comprising glucose,wherein the binary combination is effective for killing or inhibiting the growth of non-sporular bacteria when the first composition and the second composition are each in solution form and are applied concurrently to the non-sporular bacteria. 17. A binary combination for killing or inhibiting the growth of non-sporular bacteria, comprising: (a) a first composition comprising an eosinophil peroxidase; glucose oxidase; and amino acids glycine, L-alanine, and L-proline, wherein the amino acids enhance the antibacterial activity of the eosinophil peroxidase; and(b) a second composition comprising glucose,wherein the binary combination is effective for killing or inhibiting the growth of non-sporular bacteria when the first composition and the second composition are each in solution form and are applied sequentially to the non-sporular bacteria.
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