System and method of attaching soft tissue to an implant
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/28
A61F-002/30
A61K-009/00
A61L-027/32
A61L-027/50
A61L-027/56
A61L-027/04
A61L-027/54
A61B-017/08
A61L-031/02
A61L-031/16
C25D-005/34
C25D-011/02
A61L-027/34
출원번호
US-0236828
(2016-08-15)
등록번호
US-9788953
(2017-10-17)
발명자
/ 주소
Webster, Thomas J.
Perla, Venu
출원인 / 주소
PURDUE RESEARCH FOUNDATION
대리인 / 주소
Heslin Rothenberg Farley & Mesiti PC
인용정보
피인용 횟수 :
0인용 특허 :
38
초록▼
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-texture
One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.
대표청구항▼
1. An implant comprising: a porous metal region, wherein said porous metal region is reticulated and/or has pores with a diameter of 10 to 800 μm;one or more layers on the porous metal region selected from the group consisting of: a calcified material layer or calcification-inducing layer coating sa
1. An implant comprising: a porous metal region, wherein said porous metal region is reticulated and/or has pores with a diameter of 10 to 800 μm;one or more layers on the porous metal region selected from the group consisting of: a calcified material layer or calcification-inducing layer coating said porous metal region or in contact with a nanomaterial coating layer or nanosurface roughness formed on the porous metal region, if present; anda bioactive scaffold layer comprising a biocompatible polymer matrix and a bioactive agent, wherein at least a portion of the scaffold layer is in contact with the calcified material layer or calcification-inducing layer, where said calcified material layer or calcification-inducing layer is present. 2. The implant according to claim 1, wherein the pores have a diameter of 100 to 400 μm. 3. The implant according to claim 1, wherein the metal is titanium or a titanium alloy. 4. The implant according to claim 1, wherein the porous metal region is a sintered porous metal region. 5. The implant according to claim 1, wherein the pores are interconnected. 6. The implant according to claim 1, wherein the porous metal region is reticulated. 7. The implant according to claim 1, wherein the porous metal region is reticulated with interconnected pores. 8. The implant according to claim 1, additionally comprising a nanomaterial coating layer and/or nanosurface roughness formed on the porous metal region. 9. The implant according to claim 1, comprising the calcified material layer or calcification-inducing layer. 10. The implant according to claim 1, comprising the bioactive scaffold layer. 11. The implant according to claim 10, wherein the scaffold layer is uncalcified. 12. The implant according to claim 10, wherein the bioactive agent is a therapeutic drug selected from the group consisting of antibiotics, antimicrobials, steroidal and non-steroidal analgesic and anti-inflammatory drugs, immune-suppressants and anti-cancer drugs. 13. The implant according to claim 10, wherein the bioactive agent is a growth factor. 14. The implant accordingly to claim 9, comprising the calcified material layer, said calcified material layer comprising hydroxyapatite. 15. The implant according to claim 9, comprising the calcified material layer, said calcified material layer comprising a biocompatible polymer matrix. 16. The implant according to claim 15, wherein the biocompatible polymer matrix comprises collagen fibers. 17. The implant according to claim 1, wherein said porous metal region exhibits a nano-textured surface, and the implant comprises the calcified material layer coating said nano-textured surface. 18. The implant according to claim 17, wherein the calcified material layer comprises a member selected from the group consisting of hydroxyapatite and a biocompatible polymer matrix. 19. The implant according to claim 17, further comprising the bioactive scaffold layer. 20. The implant according to claim 1, wherein said porous metal region exhibits a nano-textured surface, and the implant comprises the bioactive scaffold layer. 21. The implant according to claim 8, comprising nanosurface roughness formed on the porous metal region, wherein said nanosurface roughness is physically collapsed with the calcification-inducing layer. 22. The implant according to claim 21, wherein the calcification-inducing layer comprises a bioactive agent. 23. The implant according to claim 22, wherein the bioactive agent is an antimicrobial.
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