IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0620469
(2015-02-12)
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등록번호 |
US-9795749
(2017-10-24)
|
발명자
/ 주소 |
- Thoe, Gerald A.
- Skakoon, James G.
- Schuelke, David A.
- Ruckdeschel, Thomas W.
- Harris, David
- Lewis, Scott Alexander
- Gow, Andrew Murray
- Tuckwell, Jonathan David
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
61 |
초록
▼
A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose
A dry powder inhaler includes a dose container assembly having a dose container disk with opposing upper and lower surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius. The dose containers have dry powder therein and are sealed via a first flexible sealant over apertures in the upper surface and a second flexible sealant over apertures in the lower surface. A piercing mechanism includes two reciprocating piercers that serially alternate between the two rows of dose containers in the dose container disk. A rotatable ramp disk includes first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship that are configured to move the first and second piercing members between retracted and extended positions.
대표청구항
▼
1. A dry powder inhaler, comprising: a dose container disk having a plurality of circumferentially spaced apart dry powder dose containers arranged in first and second concentric rows of different radius;a piercing mechanism; anda rotatable ramp disk comprising circumferentially spaced-apart ramp el
1. A dry powder inhaler, comprising: a dose container disk having a plurality of circumferentially spaced apart dry powder dose containers arranged in first and second concentric rows of different radius;a piercing mechanism; anda rotatable ramp disk comprising circumferentially spaced-apart ramp elements that are configured to engage the piercing mechanism and cause the piercing mechanism to sequentially open a dry powder dose container on the first row then open a dry powder dose container on the second row. 2. The dry powder inhaler of claim 1, wherein the piercing mechanism comprises first and second elongate piercing members in adjacent spaced-apart relationship, wherein each piercing member is capable of reciprocal movement between piercing and non-piercing positions, wherein the first piercing member is configured to pierce the sealant of a dose container in the first row, and wherein the second piercing member is configured to pierce the sealant of a dose container in the second row; andwherein the rotatable ramp disk comprises first and second sets of circumferentially spaced-apart ramp elements in staggered, concentric relationship, wherein the first set of ramp elements move the first piercing member between the piercing and non-piercing positions, and wherein the second set of ramp elements move the second piercing member between the piercing and non-piercing positions. 3. The dry powder inhaler of claim 2, wherein each ramp element in the first and second sets comprises a first inclined portion, a second inclined portion, and a shelf portion. 4. The dry powder inhaler of claim 2, further comprising an actuator that is movable between first and second positions, wherein the dose container disk has a sealant over an upper primary surface thereof and a sealant over a lower primary surface thereof, wherein movement of the actuator from the first position to the second position causes the ramp disk to rotate such that a ramp element in the first set causes the first piercing member to pierce the sealants over and under a dose container in the first row. 5. The dry powder inhaler of claim 4, wherein subsequent movement of the actuator from the first position to the second position causes the ramp disk to rotate such that a ramp element in the second set causes the second piercing member to pierce the sealants over and under a dose container in the second row. 6. The dry powder inhaler of claim 2, further comprising an actuator that is movable between first and second positions, wherein the dose container disk has a sealant over an upper primary surface thereof and a sealant over a lower primary surface thereof, wherein movement of the actuator from the first position to the second position causes rotation of the ramp disk which causes one of the first or second piercing members to pierce the sealants over and under a dose container, and then partially retract therefrom. 7. The dry powder inhaler of claim 2, wherein the piercing mechanism comprises a biasing member configured to urge each piercing member toward a retracted position. 8. The dry powder inhaler of claim 2, wherein each piercing member comprises a corkscrew piercer configured to pierce the sealant with a straight vertical non-rotational movement. 9. The dry powder inhaler of claim 2, wherein each piercing member comprises a fluted piercer configured to pierce the sealant. 10. The dry powder inhaler of claim 9, wherein the fluted piercer comprises three or four lobes. 11. The dry powder inhaler of claim 1, further comprising an actuator that is movable between first and second positions, wherein movement of the actuator from the first position to the second position causes the dose container disk to sealably engage an interface or wall associated with an exit airflow path in the inhaler. 12. The dry powder inhaler of claim 11, wherein the actuator comprises a biasing post, and wherein movement of the actuator from the first position to the second position causes the biasing post to urge the dose container disk to sealably engage an interface or wall associated with an exit airflow path in the inhaler. 13. The dry powder inhaler of claim 1, wherein the first row of dose container apertures have centerlines that are circumferentially spaced apart from centerlines of the second row of dose containers. 14. The dry powder inhaler of claim 1, wherein there are 30 dose container apertures in the first row and 30 dose container apertures in the second row. 15. The dry powder inhaler of claim 1, wherein each dose container comprises a dry powder having a pharmaceutically active agent selected from the group consisting of bronchodilators, inhaled corticosteroids (ICS), and anticholinergics. 16. A method of operating an inhaler, comprising: providing a dose container disk having opposing upper and lower primary surfaces, a first row of circumferentially spaced apart dose containers at a first radius and a second row of circumferentially spaced apart dose containers at a second radius, wherein the dose containers have dry powder therein, wherein each dose container terminates at a respective aperture in the upper surface and at a respective aperture in the lower surface, wherein a first flexible sealant resides over the apertures in the upper surface, and a second flexible sealant resides over the apertures in the lower surface;extending a first piercing member to open both sealants and release dry powder from a dose container in the first row;retracting the first piercing member from the first row dose container;extending a second piercing member to open both sealants and release dry powder from a dose container in the second row; andretracting the second piercing member from the second row dose container. 17. The method of claim 16, further comprising rotating the dose container disk by a predetermined amount after retracting the first piercing member from the first row dose container and prior to extending the second piercing member to open both sealants and release dry powder from the dose container in the second row. 18. The method of claim 16, further comprising causing the dose container disk to sealably engage an interface or wall associated with an exit airflow path in the inhaler prior to extending the first piercing member to open both sealants and release dry powder from a dose container in the first row, and causing the dose container disk to sealably engage the interface or wall associated with the exit airflow path in the inhaler prior to extending the second piercing member to open both sealants and release dry powder from a dose container in the second row.
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