Devices, systems and methods for detecting a bilateral differential in olfactory threshold for pure odorants
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/087
출원번호
US-0282622
(2014-05-20)
등록번호
US-9801581
(2017-10-31)
발명자
/ 주소
Mills, Gregory B.
출원인 / 주소
Inspired Technologies, Inc.
대리인 / 주소
Barnes & Thornburg LLP
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present inventio
The present system is directed in various embodiments to devices, systems and methods for detection, evaluation and/or monitoring olfactory dysfunction by measuring and determining the patient's olfactory detection threshold for the left and the right nostril. More specifically, the present invention relates to devices, systems and methods for detecting an asymmetric differential in a patient's olfactory detection threshold (left vs right nostril) which, when present, may be used as a device to detect, diagnose and/or monitor olfactory deterioration resulting from certain neurodegenerative disorders such as Alzheimer's disease.
대표청구항▼
1. A nasal testing device for detecting a patient's pure odorant bilateral olfactory detection threshold for a nostril, comprising: a housing, the housing comprising:a pure odorant compartment within the housing and comprising a pure odorant within the pure odorant compartment;a left airway passage
1. A nasal testing device for detecting a patient's pure odorant bilateral olfactory detection threshold for a nostril, comprising: a housing, the housing comprising:a pure odorant compartment within the housing and comprising a pure odorant within the pure odorant compartment;a left airway passage defined within the housing and in fluid communication with a clear air source and in switchable communication with the pure odorant compartment;a right airway passage defined within the housing and in fluid communication with the clear air source and in switchable communication with a pure odorant located within the pure odorant compartment;a left nasal tip having a lumen therethrough and in fluid communication with the left airway passage;a right nasal tip having a lumen therethrough and in fluid communication with the right airway passage;a left airway one-way valve in fluid communication with the lumen of the left nasal tip and the left airway passage and a right airway one-way valve in fluid communication with the lumen of the right nasal tip and the right airway passage, the left and right airway one-way valves allowing exhalation but not inhalation therethrough;a floating ball within the left airway; and a floating ball within the right airway, the floating balls adapted to indicate relative inhalation force, wherein the inhalation force through the left and right airways is generated exclusively from the patient's inhalation at the right and left nasal tips;a left airway activation switch, adapted to switch the left airway out of fluid communication with the clear air source into fluid communication with the pure odorant compartment, thereby introducing pure-odorant infused air into the left airway passage when the right airway remains in fluid communication with the clear air source;a right airway activation switch, adapted to switch the right airway out of fluid communication with the clear air source and into fluid communication with the pure odorant compartment, thereby introducing pure-odorant infused air into the right airway passage when the left airway remains in fluid communication with the clear air source,wherein the left airway activation switch is adapted to further switch the left airway passage out of fluid communication with the pure odorant compartment and into fluid communication with the clear air source when the right airway is switched into fluid communication with the pure odorant compartment; andwherein the right airway activation switch is adapted to further switch the right airway passage out of fluid communication with the pure odorant compartment and into fluid communication with the clear air source when the left airway is switched into fluid communication with the pure odorant compartment. 2. The device of claim 1, wherein the pure odorant is selected from the group consisting of: peanut butter, coffee, vanilla, cinnamon, and lavender. 3. The device of claim 1, wherein the clear air source is selected from the group consisting of: an air pump, a nebulizer, a compressed air device, and ambient air. 4. The device of claim 1, wherein each nasal tip forms a substantial seal with the patient's nostrils. 5. The device of claim 4, wherein each nasal tip is removable. 6. The device of claim 5, wherein each nasal tip comprises a disposable nasal specula tip. 7. The device of claim 1, wherein the clear air source is ambient air and a flow of clear air through the clear airway passage is initiated by the force of the patient's inhalation of clear air through the clear airway passage. 8. The device of claim 1, wherein the first and second nasal tips each form a seal with one of the patient's nostrils. 9. The device of claim 1, further comprising an ultrasonic aroma emitting source disposed within the pure odorant compartment and in operative connection with a power source, the ultrasonic aroma emitting source in operational communication with the left and right airway passages sequentially and adapted to emit pure odorant aromas only that stimulate the first cranial nerve but not the fifth cranial nerve, without emission of odorants that stimulate at least the fifth cranial nerve. 10. The device of claim 1, wherein the first and second nasal tips are color coded. 11. The device of claim 1, wherein the device is controlled by, and in two-way communication with, a programmable computing device. 12. The device of claim 11, wherein the programmable computing device comprises a software application having a time keeping function, a results database, a random nostril event and odorant generator, and a remote server in communication with the programmable computing device and comprising a memory and a processor in communication with the memory with programmed instructions stored therein adapted to generate a test score based on test trial data obtained for each nostril. 13. The device of claim 1, further comprising the left and right airway passages comprising a coating that repels the pure odorant molecules.
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이 특허에 인용된 특허 (8)
Walker James C. (Winston-Salem NC) Kurtz Daniel B. (Winston-Salem NC) Shore Ford M. (Winston-Salem NC), Apparatus for assessing responses of humans to stimulants.
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