Hemostasis of wound having high pressure blood flow using kaolin and bentonite
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61L-015/18
A61L-026/00
출원번호
US-0797662
(2010-06-10)
등록번호
US-9821084
(2017-11-21)
발명자
/ 주소
Diegelmann, Robert F.
Ward, Kevin R.
Carr, Marcus E.
Bowlin, Gary Lee
출원인 / 주소
Virginia Commonwealth University
대리인 / 주소
Whitham, Curtis & Cook, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
102
초록▼
Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, e
Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided.
대표청구항▼
1. A bandage for providing hemostasis in a hemorrhaging wound having a high-pressure blood flow, comprising: a substrate;a composition including kaolin associated with said substrate, wherein said kaolin is positioned with respect to said substrate so as to contact a hemorrhaging wound when said ban
1. A bandage for providing hemostasis in a hemorrhaging wound having a high-pressure blood flow, comprising: a substrate;a composition including kaolin associated with said substrate, wherein said kaolin is positioned with respect to said substrate so as to contact a hemorrhaging wound when said bandage is applied to said hemorrhaging wound, wherein said kaolin is present in a quantity sufficient to promote blood clotting and hemostasis and to stanch high pressure blood flow from the hemorrhaging wound, and wherein said composition does not include ingredients which cause an exothermic reaction when in contact with blood. 2. The bandage of claim 1 wherein said substrate is gauze. 3. The bandage of claim 1 wherein said substrate is a flexible sponge material. 4. The bandage of claim 1, wherein said kaolin is in a form selected from the group consisting of granules, liquid, gel, and micron beads. 5. The bandage of claim 1, further comprising one or more substances selected from the group consisting of chitosan, fibrin, superabsorbent polymers, polyethylene glycol, vasoactive catecholamines, vasoactive peptides, antimicrobial agents, and anesthetic agents. 6. The bandage of claim 1, further comprising a flexible substrate that is affixed to a body part remote from said hemorrhaging wound. 7. The bandage of claim 1, wherein said kaolin is in a form selected from the group consisting a mortar, a foam, a viscous liquid, incorporated into a fiber material, and a semisolid-semiliquid. 8. The bandage of claim 1, wherein said kaolin is a powder. 9. The bandage of claim 1, wherein said kaolin is in a paste. 10. The bandage of claim 1, wherein said kaolin is impregnated in the bandage. 11. The bandage of claim 1, wherein said substrate is configured to conform to the shape of said wound. 12. The bandage of claim 1, wherein said substrate is a gauze. 13. The bandage of claim 1, wherein said bandage comprises a sponge material. 14. The bandage of claim 1, further comprising fibrinogen. 15. The bandage of claim 1, further comprising thrombin. 16. The bandage of claim 1, further comprising calcium. 17. The bandage of claim 1, further comprising dextran. 18. The bandage of claim 1, further comprising one or more cellulose types. 19. The bandage of claim 1, wherein said quantity of kaolin is sufficient to stanch blood flow from arterial bleeding. 20. The bandage of claim 1, wherein said quantity of kaolin is sufficient to stanch blood flow from a hemorrhaging wound caused by intentional trauma. 21. The bandage of claim 1, wherein bandage is configured for use in a medical procedure. 22. The bandage of claim 15, wherein said quantity of kaolin is sufficient to stanch blood flow of heparinized blood. 23. The bandage of claim 15, wherein said bandage is configured for use in treating a bullet wound or a knife wound. 24. A device for providing hemostasis in a hemorrhaging wound having a high-pressure blood flow, comprising: a substrate;a composition including kaolin on or in said substrate, wherein said kaolin is positioned with respect to said substrate so as to contact a hemorrhaging wound when said substrate is applied to said hemorrhaging wound, wherein said kaolin is present in a quantity sufficient to promote blood clotting and hemostasis and to stanch high pressure blood flow from the hemorrhaging wound. 25. The device of claim 24, wherein said kaolin comprises a powder. 26. The device of claim 24, wherein said kaolin is in a paste. 27. The device of claim 24, wherein said kaolin is impregnated in a bandage. 28. The device of claim 24, wherein said kaolin is electrospun into a bandage. 29. The device of claim 24, wherein said substrate is configured to conform to the shape of said wound. 30. The device of claim 24, wherein said substrate is a gauze. 31. The device of claim 24, wherein said substrate comprises a sponge material. 32. The device of claim 24, further comprising fibrinogen. 33. The device of claim 24, further comprising thrombin. 34. The device of claim 24, further comprising dextran. 35. The device of claim 24, further comprising a cellulose. 36. The device of claim 24, wherein said quantity of kaolin is sufficient to stanch blood flow from arterial bleeding. 37. The device of claim 24, wherein said quantity of kaolin is sufficient to stanch blood flow from a hemorrhaging wound caused by intentional trauma. 38. The device of claim 24, wherein said device is configured for use in a medical procedure. 39. The device of claim 24, wherein said quantity of kaolin is sufficient to stanch blood flow of heparinized blood. 40. The device of claim 24, wherein said device is configured to stanch high-pressure blood flow from an organ.
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