초록 ▼

An in vitro method of prognostically assessing tissue regeneration capacity and/or cellular potency and/or the prospects of success of an implantation and/or transplantation, wherein the transcriptome and/or the gene expression of cells, the gene expression originating from the transcriptome, are an

An in vitro method of prognostically assessing tissue regeneration capacity and/or cellular potency and/or the prospects of success of an implantation and/or transplantation, wherein the transcriptome and/or the gene expression of cells, the gene expression originating from the transcriptome, are analyzed.

대표청구항 ▼

1. A method of preparing an implant comprising chondrocytes comprising: culturing chondrocytes;prognostically assessing prospects of success of an implantation and/or transplantation of the chondrocytes of the implant in vitro by determining mRNA expression in cultured chondrocytes of at least one t

1. A method of preparing an implant comprising chondrocytes comprising: culturing chondrocytes;prognostically assessing prospects of success of an implantation and/or transplantation of the chondrocytes of the implant in vitro by determining mRNA expression in cultured chondrocytes of at least one two-marker combination selected from the group consisting of type II collagen and IL-1 beta; type II collagen and FLT-1; and type II collagen and BSP-2; andinoculating the implant with the cultured chondrocytes. 2. The method according to claim 1, wherein the mRNA expression is determined by quantitative real-time PCR. 3. The method of claim 1, wherein the chondrocytes are autologous cells. 4. The method of claim 1, wherein the chondrocytes are articular chondrocytes. 5. The method of claim 1, wherein the chondrocytes are healthy cells. 6. The method of claim 1, wherein the implantation is a support-assisted autologous chondrocyte transplantation. 7. The method of claim 1, wherein the transplantation is an autologous chondrocyte transplantation.