Methods of using regenerative cells in the treatment of erectile dysfunction
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-035/28
A61L-027/38
C12N-005/0775
C12N-005/071
A61K-035/44
A61K-045/06
A61K-009/00
출원번호
US-0567937
(2014-12-11)
등록번호
US-9849149
(2017-12-26)
발명자
/ 주소
Fraser, John K.
Hedrick, Marc H.
Daniels, Eric
출원인 / 주소
Cytori Therapeutics, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
117
초록▼
Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be p
Cells present in adipose tissue are used to treat patients, including patients with PVD and related diseases or disorders. Methods of treating patients include processing adipose tissue to deliver a concentrated amount of stem cells obtained from the adipose tissue to a patient. The methods may be practiced in a closed system so that the stem cells are not exposed to an external environment prior to being administered to a patient. Accordingly, in a preferred method, cells present in adipose tissue are placed directly into a recipient along with such additives necessary to promote, engender or support a therapeutic benefit.
대표청구항▼
1. A method of treating erectile dysfunction in a subject, comprising: identifying a subject with erectile dysfunction; andproviding to the subject an amount of a concentrated population of adipose-derived regenerative cells comprising stem cells and endothelial progenitor cells that is sufficient t
1. A method of treating erectile dysfunction in a subject, comprising: identifying a subject with erectile dysfunction; andproviding to the subject an amount of a concentrated population of adipose-derived regenerative cells comprising stem cells and endothelial progenitor cells that is sufficient to ameliorate said physiologic erectile dysfunction, wherein said concentrated population of adipose-derived regenerative ells is obtained by acquiring an adipose tissue sample, separating away adipocytes and connective tissue, and washing and concentrating said adipose-derived regenerative cells. 2. The method of claim 1, further comprising providing an additive to said concentrated population of adipose-derived regenerative cells. 3. The method of claim 1, wherein said subject is human. 4. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is provided to said subject in multiple doses. 5. The method of claim 1, further comprising providing one or more angiogenic factors to said subject or to said concentrated population of adipose-derived regenerative cells. 6. The method of claim 1, further comprising providing one or more immunosuppressive drugs to said subject or to said concentrated population of adipose-derived regenerative cells. 7. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is provided to said subject via at least one of an intravenous, intra-muscular or subcutaneous administration route. 8. The method of claim 1, wherein the concentrated population of adipose-derived regenerative cells is provided on a scaffold. 9. The method of claim 8, wherein the scaffold is resorbable in vivo. 10. The method of claim 8, wherein said scaffold is a unit of adipose tissue. 11. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is autologous. 12. The method of claim 1, further comprising measuring blood flow by a method selected from the group consisting of: duplex ultrasonography, angiography, and magnetic resonance angiography. 13. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is isolated in a system comprising: a tissue collection chamber that is configured to receive unprocessed adipose tissue that is removed from a subject, wherein said tissue collection chamber is defined by a closed system;a first filter that is disposed within said tissue collection chamber, wherein said first filter is configured to retain a first component of said unprocessed adipose tissue and pass a second component of said unprocessed adipose tissue, such that said first filter substantially separates said first component from said second component, and wherein said first component comprises a cell population that comprises adipose-derived stem cells, and said second component comprises lipid, mature adipocytes, and saline;a processing chamber, which is configured to receive said first component comprising said cell population that comprises adipose-derived stem cells from said tissue collection chamber, wherein said processing chamber is within said closed system;a conduit configured to allow passage of said first component comprising said cell population comprising adipose-derived stem cells from said tissue collection chamber to said processing chamber while maintaining a closed system;a cell concentrator disposed within said processing chamber, which is configured to facilitate the concentration of said first component comprising said cell population that comprises adipose-derived stem cells so as to obtain a concentrated population of cells that comprises adipose-derived stem cells, wherein said cell concentrator comprises a centrifugation device or a filter; andan outlet configured to allow the aseptic removal of said concentrated population of cells that comprise adipose-derived stem cells. 14. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is not cultured. 15. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is cultured. 16. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is cryopreserved. 17. The method of claim 1, wherein said concentrated population of adipose-derived regenerative cells is administered via a catheter.
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