Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/539
A61K-031/35
A61K-036/11
A61K-036/15
A61K-036/185
A61K-036/28
A61K-036/47
A61K-036/48
A61K-036/484
A61K-036/486
A61K-036/53
A61K-036/54
A61K-036/60
A61K-036/906
A61K-036/9062
A61K-031/353
A61K-031/7048
A61K-036/74
출원번호
US-0186113
(2016-06-17)
등록번호
US-9849152
(2017-12-26)
발명자
/ 주소
Jia, Qi
출원인 / 주소
Unigen, Inc.
대리인 / 주소
Seed IP Law Group LLP
인용정보
피인용 횟수 :
0인용 특허 :
84
초록▼
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provid
The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
대표청구항▼
1. A composition, comprising a mixture of an enriched Scutellaria extract comprising Free-B-ring flavonoids containing baicalin, and an enriched Uncaria extract comprising flavans containing catechin and/or epicatechin, wherein the Scutellaria extract is from Scutellaria baicalensis or Scutellaria o
1. A composition, comprising a mixture of an enriched Scutellaria extract comprising Free-B-ring flavonoids containing baicalin, and an enriched Uncaria extract comprising flavans containing catechin and/or epicatechin, wherein the Scutellaria extract is from Scutellaria baicalensis or Scutellaria orthocalyx, wherein the Uncaria extract is from Uncaria gambir, Uncaria tomentosa, or Uncaria africana, andwherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 70:30 to 90:10. 2. The composition of claim 1, wherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 80:20 to 85:15. 3. The composition of claim 1, wherein at least 80% of the total weight of the composition comprises Free-B-ring flavonoids and flavans. 4. The composition of claim 1, wherein the major active components of the composition are the Free-B-ring flavonoids and the flavans. 5. The composition of claim 1, wherein the major active ingredients of the composition are baicalin, catechin, and epicatechin. 6. The composition of claim 1, wherein the Free-B-ring flavonoids and the flavans are extracted from a plant part selected from the group consisting of stems, stem barks, trunks, trunk barks, twigs, tubers, roots, root barks, young shoots, seeds, rhizomes, flowers, and leaves. 7. The composition of claim 1, wherein each extract is enriched from a hot water extract. 8. The composition of claim 1, wherein each extract is enriched from an alcohol extract. 9. The composition of claim 1, wherein the Scutellaria extract is from Scutellaria baicalensis, and the Uncaria extract is from Uncaria gambir. 10. The composition of claim 9, wherein each extract is enriched from a hot water extract. 11. The composition of claim 10, wherein the ratio of Free-B-ring flavonoids to flavans in the composition ranges from 80:20 to 85:15. 12. The composition of claim 11, further comprising an adjuvant, excipient or carrier. 13. The composition of claim 12, wherein the adjuvant, excipient or carrier is selected from one or more of calcium-based salts, silica, boron, histidine, glucosamine sulfate, chondroitin sulfate, copper gluconate, cellulose, dextrose, saline, water, oil, vitamin D, and shark and bovine cartilage. 14. The composition of claim 9, wherein each extract is enriched from an alcohol extract. 15. The composition of claim 1, further comprising an adjuvant, excipient or carrier. 16. The composition of claim 15, wherein the adjuvant, excipient or carrier is selected from one or more of calcium-based salts, silica, boron, histidine, glucosamine sulfate, chondroitin sulfate, copper gluconate, cellulose, dextrose, saline, water, oil, vitamin D, and shark and bovine cartilage.
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