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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0240797 (2011-09-22) |
등록번호 | US-9878101 (2018-01-30) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 630 |
A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The
A package including a vessel made of cyclic olefin polymer (COP) resin, a CVD coating on a vessel, and a medicament comprising at least one protein, peptide, and/or DNA sequence is disclosed. Methods for processing a vessel, for example to provide lubricity or hydrophobicity, are also disclosed. The interior surface of the seated vessel can be processed via the vessel port by PECVD. Vessel barrier, lubricity and hydrophobic coatings and coated vessels, for example syringes and medical sample collection tubes are disclosed.
1. A package containing a pharmaceutical composition, the package comprising: a container comprising a syringe barrel having a wall defining a lumen, the wall having a wall interior surface consisting essentially of a cyclic olefin polymer (COP) free of co-monomers, a barrier coating on at least a p
1. A package containing a pharmaceutical composition, the package comprising: a container comprising a syringe barrel having a wall defining a lumen, the wall having a wall interior surface consisting essentially of a cyclic olefin polymer (COP) free of co-monomers, a barrier coating on at least a portion of the wall interior surface, the coating consisting essentially of a material comprising the atomic ratio SiOx measured by X-ray photoelectron spectroscopy (XPS), in which x is from 1.5 to 2.9, anda plasma enhanced chemical vapor deposition (PECVD) lubricity coating over the barrier coating, comprising the following atomic ratio, measured by XPS, SiwOxCy where w is 1, x in this formula is from about 0.5 to 2.4, and y is from about 0.6 to about 3, the wall interior surface coated with the barrier coating and the lubricity coating having at least 25% lower sliding frictional resistance or at least 25% lower breakout frictional resistance than the wall interior surface lacking the barrier coating and the lubricity coating, as measured in accordance with ISO 7886-1:1993; anda composition contained in the lumen comprising: one or more active medicaments which are at least one of a protein, a peptide, or a DNA sequence;a water; andat least one organic preservative. 2. The package of claim 1, in which the package further comprises a stopper, plunger or piston located at least partially within the lumen and slidable along the wall interior surface. 3. The package of claim 1, in which the organic preservative comprises at least one of m-cresol, benzyl alcohol, and phenol. 4. The package of claim 1, in which the one or more active medicaments comprises pharmaceutical insulin. 5. The package of claim 1, further comprising a plunger or piston having a front face, a side portion, and a back portion, the side portion being configured to movably seat within the syringe barrel, at least a portion of the front face made of cyclic olefin polymer resin. 6. A medical or diagnostic kit comprising the package of claim 1;a hypodermic needle, double-ended needle, or other delivery conduit; andoptionally, an instruction sheet. 7. The package of claim 1, in which the wall is made from a single COP composition. 8. The package of claim 1, in which the plasma enhanced chemical vapor deposition (PECVD) lubricity coating is a PECVD reaction product employing a gaseous precursor comprising octamethylcyclotetrasiloxane (OMCTS).
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