최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0266612 (2014-04-30) |
등록번호 | US-9882660 (2018-01-30) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 406 |
Method, system and computer program product for providing real time detection of analyte sensor sensitivity decline is continuous glucose monitoring systems are provided.
1. A system for detecting signal attenuation comprising: an analyte sensor for positioning under a skin surface in fluid contact with bodily fluid; anda data processing device comprising a memory, wherein the data processing device is operatively coupled to the analyte sensor, the data processing de
1. A system for detecting signal attenuation comprising: an analyte sensor for positioning under a skin surface in fluid contact with bodily fluid; anda data processing device comprising a memory, wherein the data processing device is operatively coupled to the analyte sensor, the data processing device configured to receive a first plurality of analyte sensor related signals from the analyte sensor within a first predetermined time period determined within the first 24 hours of analyte sensor positioning under the skin surface,wherein a computer program is stored on the memory such that, when executed, the computer program causes the data processing device: to determine a probability of signal attenuation associated with the analyte sensor based at least in part on the first plurality of analyte sensor related signals,to determine a sensitivity of the analyte sensor based on a second plurality of analyte sensor related signals from the analyte sensor and a reference analyte measurement, the reference analyte measurement comprising a finger stick measurement of a blood analyte level,to determine a sensitivity ratio based on the determined sensitivity of the analyte sensor divided by a nominal sensitivity determined prior to analyte sensor positioning, the nominal sensitivity comprising a sensitivity value of the analyte sensor at the time of manufacture, andto verify a presence of signal attenuation associated with a decline in analyte sensor sensitivity when the determined sensitivity ratio is less than a first predetermined signal attenuation threshold level. 2. The system of claim 1, wherein the computer program, when executed, causes the data processing device to determine one or more characteristics associated with the first plurality of analyte sensor related signals, and to apply a predetermined coefficient to the first plurality of analyte sensor related signals. 3. The system of claim 1, wherein the computer program, when executed, causes the data processing device to generate a second output signal associated with absence of signal attenuation when the determined probability of signal attenuation does not exceed the first predetermined signal attenuation threshold level. 4. The system of claim 1, wherein the computer program, when executed, causes the data processing device to select a signal attenuation threshold level and confirm the presence of signal attenuation based at least in part on a comparison of the determined sensitivity ratio and the selected signal attenuation threshold level. 5. The system of claim 1, wherein the computer program, when executed, causes the data processing device to determine the sensitivity of the analyte sensor as a ratio of the average of the second plurality of analyte sensor related signals and the reference analyte measurement. 6. The system of claim 1, including a user output unit operatively coupled to the data processing device to display an output signal associated with the presence of signal attenuation. 7. The system of claim 1, wherein the second plurality of analyte sensor related signals from the analyte sensor are approximately contemporaneous with the reference analyte measurement. 8. The system of claim 2, wherein the determined one or more characteristics includes one or more of a mean value associated with the first plurality of analyte sensor related signals, a least square slope associated with the first plurality of analyte sensor related signals, a standard deviation associated with the first plurality of analyte sensor related signals, an average elapsed time from positioning the analyte sensor, or a variance about a least squares slope associated with the first plurality of analyte sensor related signals. 9. The system of claim 4, wherein the selected signal attenuation threshold level is associated with the reference analyte measurement. 10. The system of claim 4, wherein the computer program, when executed, causes the data processing device to determine that the sensitivity ratio of the analyte sensor is less than the selected signal attenuation threshold level.
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