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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0639114 (2017-06-30) |
등록번호 | US-9884017 (2018-02-06) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 6 인용 특허 : 612 |
The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
1. A foamable composition formulated for skin delivery of an active agent comprising: a minocycline in a therapeutically effective amount of about 1 to about 5% by weight of the composition;a short chain alcohol comprising ethanol;about 12% to about 30% by weight of the composition of a protic polar
1. A foamable composition formulated for skin delivery of an active agent comprising: a minocycline in a therapeutically effective amount of about 1 to about 5% by weight of the composition;a short chain alcohol comprising ethanol;about 12% to about 30% by weight of the composition of a protic polar solvent comprising propylene glycol;a polymeric agent comprising a cellulose ether;a modulating agent comprises an antioxidizing agent;a metal;an essential oil;wherein the foamable composition is surfactant free;and wherein the composition is waterless and essentially free of fatty alcohol. 2. The foamable composition according to claim 1, wherein the minocycline is a minocycline hydrochloride. 3. The foamable composition according to claim 1, wherein the therapeutically effective amount is about 1%. 4. The foamable composition according to claim 1, wherein the therapeutically effective amount is about 4%. 5. The foamable composition according to claim 1, wherein the short chain alcohol is present in an amount of at least 55% by weight of the composition. 6. The foamable composition according to claim 1, wherein the cellulose ether is a hydroxypropyl cellulose. 7. The foamable composition according to claim 1, wherein the modulating agent is present in an amount ranging from about 0.1% to about 10% by weight of the composition. 8. The foamable composition according to claim 7, wherein the modulating agent is present in an amount ranging from about 1% to about 5% by weight of the composition. 9. The foamable composition according to claim 1, wherein the cellulose ether is present in an amount ranging from about 0.5% to about 1% by weight of the composition. 10. The foamable composition according to claim 1, wherein: the minocycline is minocycline hydrochloride; andthe cellulose ether is a hydroxypropyl cellulose. 11. The foamable composition according to claim 10, wherein: the ethanol is present in an amount of at least 55% by weight of the composition;the hydroxypropyl cellulose is present in an amount of about 0.5% to about 1% by weight of the composition; andthe modulating agent is present in an amount ranging from about 0.1% to about 10% by weight of the composition. 12. The foamable composition according to claim 11, wherein the therapeutically effective amount is about 1% by weight of the composition. 13. The foamable composition according to claim 11, wherein the therapeutically effective amount is about 4% by weight of the composition. 14. The foamable composition according to claim 1, wherein the liquefied or compressed gas propellant is present in an amount ranging from about 3% to about 25% by weight of the composition.
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