Biomedical device, method for manufacturing the same and use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
B22F-003/105
A61F-002/28
A61L-027/56
A61L-027/12
B28B-001/00
B05D-001/02
C04B-035/119
C23C-016/44
B22F-003/11
B29C-067/00
B29K-101/12
출원번호
US-0487464
(2014-09-16)
등록번호
US-9889012
(2018-02-13)
우선권정보
WO-PCT/IB2009/054225 (2009-07-23)
발명자
/ 주소
Nimal, Didier
출원인 / 주소
Nimal, Didier
대리인 / 주소
Young & Thompson
인용정보
피인용 횟수 :
0인용 특허 :
4
초록▼
A method for manufacturing a three-dimensional biomedical device for fitting in a bone defect having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from an absorbent and from a first powder including one of ceramics, metals, metal all
A method for manufacturing a three-dimensional biomedical device for fitting in a bone defect having an osteoinductive first area with a controlled porosity and a second area, which is produced by laser technology from an absorbent and from a first powder including one of ceramics, metals, metal alloys, bioactive glasses, lead zirconate titanate and biocompatible polymers, or mixtures thereof, wherein the ratio of the porosities from the second area to the first area is equal or less than one, preferably from 0.001 to 0.9, wherein a virtual object is designed with a computer-aid designed software, and the device is manufactured by laser technology including layering a powder onto a plate (7) so that a layer of a predetermined thickness is formed; the laser beam (8) selectively processes the powder to produce a processed layer, and, thus, layer after layer, the layers are joined together until the biomedical device is formed.
대표청구항▼
1. A method for manufacturing a biomedical device for fitting bone defect, said biomedical device having at least one osteoconductive first area with a controlled porosity and at least one porous second area, the ratio of the porosity of the second area to the porosity of the first area being equal
1. A method for manufacturing a biomedical device for fitting bone defect, said biomedical device having at least one osteoconductive first area with a controlled porosity and at least one porous second area, the ratio of the porosity of the second area to the porosity of the first area being equal or less than one, wherein the device is produced by a laser technology from an absorbent and from a first powder comprising a material selected from the group consisting of ceramics, bioactive glasses, and mixtures thereof, wherein the laser is a pulsed laser or a continuous laser of 100 to 1200 watts, and the laser progression speed of the laser beam ranges from 0.01 and 5000 mm/s; and wherein an image of the defect is performed,from this image, a virtual object is designed with a computer-aid designed software,optionally, a scale model is performed,the biomedical device is manufactured by a laser technology comprising: layering onto a plate either: a mixture of the first powder and the absorbent;a first powder coated with the absorbent; orthe first powder, whereon subsequently the absorbent is selectively deposited in a predefined trajectory; so that a layer of a predetermined thickness is formed on the plate, having the laser beam selectively processed the layer to produce a processed layer, and this, layer after layer, the layers being joined together until the completed biomedical device is formed,wherein the ceramics are selected from the group consisting of alumina or alumina derivative, ceramic phosphates, apatite derivatives, zirconia, zirconia derivatives, zirconia-toughened alumina (ZTA), alumina-toughened-zirconia (ATZ), alumina-zircona, ytria-Zirconia (TZP), and wallostonite; andthe bioactive glasses are silicate derivatives comprising SiO2, CaO and optionally Na2O, and/or optionally P2O5. 2. The method according to claim 1, wherein the absorbent comprises carbon, scandium, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, or zinc or any compound comprising at least one of said chemical elements, or mixture thereof. 3. The method according to claim 1, wherein said biomedical device comprises a mixture hydroxyapatite/tricalcium phosphate in a ratio ranging from 55/45 to 90/10. 4. The method according to claim 1, wherein the absorbent is selectively deposited by means of a nozzle, a spray, a jet or a printing head. 5. The method according to claim 1, wherein the absorbent is coated on the first powder by wet process, Chemical Vapor Deposition. 6. The method according to claim 1, wherein the particles of the first powder have a granulometry of 1 to 500 micrometers. 7. The method according to claim 1, wherein the particle size of the absorbent ranges from 1 nanometer to 500 micrometers. 8. The method according to claim 1, wherein the thickness of the layer of powder ranges from 0.1 to 2000 micrometers. 9. The method according to claim 1, further comprising a step of heating the powder prior to the layering step, at a temperature of 200 to 1500° C. 10. The method according to claim 1, further comprising a step of thermic post-treatment at a temperature of 200 to 1200° C. for removing the absorbent. 11. The method according to claim 1, wherein the laser is a 160 watts laser. 12. The method according to claim 1, wherein the laser is adjusted at 1 to 25% of the total power of the laser. 13. The method according to claim 1, wherein the particle size of the absorbent ranges from 1 nanometer to 200 micrometers. 14. The method according to claim 1, wherein the particle size of the absorbent ranges from 10 nanometers to 100 nanometers.
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이 특허에 인용된 특허 (4)
Jill K. Sherwood ; Linda G. Griffith ; Scott Brown, Composites for tissue regeneration and methods of manufacture thereof.
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