Devices and methods for vestibular and/or cranial nerve stimulation
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-018/18
A61F-007/12
A61F-007/00
출원번호
US-0913595
(2013-06-10)
등록번호
US-9913749
(2018-03-13)
발명자
/ 주소
Rogers, Lesco L.
Smith, Lanty L.
출원인 / 주소
Scion NeuroStim, LLC
대리인 / 주소
Myers Bigel, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
20
초록▼
An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; a
An in-ear stimulator for administering thermal stimulation to the ear canal of a subject includes (a) an earpiece configured to be insertable into the ear canal of said subject, the earpiece having an outer surface and an internal cavity formed therein, the internal cavity having an inner surface; and (b) at least one thermoelectric device thermally coupled to the earpiece internal cavity inner surface.
대표청구항▼
1. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: (a) an earpiece configured to be at least partially insertable into the ear canal of the subject;(b) at least one thermoelectric device thermally coupled to said earpiece and configured to heat o
1. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: (a) an earpiece configured to be at least partially insertable into the ear canal of the subject;(b) at least one thermoelectric device thermally coupled to said earpiece and configured to heat or cool said earpiece to thereby heat or cool the ear canal of the subject; and(c) a controller configured to deliver a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject, wherein the controller is configured to deliver the time-varying thermal waveform such that the time-varying thermal waveform comprises an amplitude that increases or decreases through a plurality of different temperature points over time. 2. The stimulator of claim 1, further comprising a heat sink thermally coupled to said at least one thermoelectric device and configured for positioned outside the ear canal of a subject. 3. The stimulator of claim 2, wherein said heat sink comprises a generally planar surface, said earpiece having a corresponding cooperating planar surface, said at least one thermoelectric device being mounted between said heat sink planar surface and said cooperating portion of said earpiece planar surface. 4. The stimulator of claim 3, wherein the heat sink outer portion comprises a plurality of fins. 5. The stimulator of claim 2, wherein said heat sink comprises aluminum. 6. The stimulator of claim 2, wherein said heat sink has a weight between about 30 grams and about 70 grams. 7. The stimulator of claim 2, wherein said earpiece is thermally coupled to a first side of the at least one thermoelectric device and said heat sink is thermally coupled to an opposing second side of the at least one thermoelectric device. 8. The stimulator of claim 1, wherein said earpiece is formed from a rigid, thermally-conductive material. 9. The stimulator of claim 1, wherein said earpiece comprises aluminum. 10. The stimulator of claim 1, wherein said earpiece weighs about 12 grams or less. 11. The stimulator of claim 1, wherein the at least one thermoelectric device comprises a plurality of thermoelectric devices. 12. The stimulator of claim 11, wherein said plurality of thermoelectric devices are thermally coupled to one another. 13. The stimulator of claim 12, wherein said at least one thermoelectric device comprises a thin film thermoelectric device. 14. The stimulator of claim 1, wherein said earpiece is conical in shape. 15. The stimulator of claim 14, wherein said earpiece comprises a circular cone. 16. The stimulator of claim 14, wherein said earpiece comprises a conical apex of the conical shape that has been blunted to form a dome-shaped point. 17. The stimulator of claim 16, wherein said earpiece comprises: a generally cylindrical base having opposite first and second ends, the base defining a longitudinal centerline; and an extended portion extending from the second end of the cylindrical base, wherein said dome-shaped point is offset from the longitudinal centerline. 18. The stimulator of claim 1, wherein the cross-sectional area of the extended portion decreases as a function of distance away from said base. 19. The stimulator of claim 18, wherein the extended portion tapers unevenly from said cylindrical base to said dome-shaped point. 20. The stimulator of claim 1, further comprising a head piece, wherein said head piece is configured for positioning the earpiece in the ear canal of the subject. 21. An in-ear stimulator for administering thermal stimulation to the ear canals of a subject, comprising: (a) a first earpiece configured to be at least partially insertable into the right ear canal of the subject; (b) a second earpiece configured to be at least partially insertable into the left ear canal of the subject; (c) at least one thermoelectric device thermally coupled to said first earpiece and configured to heat or cool said first earpiece to thereby thermally stimulate the right ear canal of the subject; (d) at least one thermoelectric device thermally coupled to said second earpiece and configured to heat or cool said second earpiece to thereby thermally stimulate the left ear canal of the subject; (e) a headpiece configured to position said first earpiece in the right ear canal of the subject and to position said second earpiece in the left ear canal of the subject. 22. The stimulator of claim 21, wherein said headpiece comprises a flexible or adjustable, band. 23. The stimulator of claim 22, further comprising: a first heat sink thermally coupled to said at least one thermoelectric device coupled to said first earpiece; and a second heat sink thermally coupled to said at least one thermoelectric device coupled to said first earpiece. 24. A method for delivering caloric stimulation to a subject, the method comprising: positioning at least a portion of an in-ear stimulator in an ear canal of the subject, said in-ear stimulator comprising: (a) an earpiece configured to be at least partially insertable into the ear canal of the subject; and (b) at least one thermoelectric device thermally coupled to said earpiece and configured to heat or cool said earpiece to thereby thermally stimulate the ear canal of the subject; delivering a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject, wherein delivering a time-varying thermal waveform to said at least one thermoelectric device comprises delivering a time-varying thermal waveform such that the time-varying thermal waveform comprises an amplitude that increases or decreases through a plurality of different temperature points over time. 25. The method of claim 24, wherein said stimulator further comprises a heat sink positioned in said earpiece internal cavity, wherein said heat sink is thermally coupled to said at least one thermoelectric device. 26. An in-ear stimulator for administering thermal stimulation to the ear canal of a subject, comprising: a heat sink thermally coupled to at least one thermoelectric device and having at least an outer portion of said heat sink that is configured for positioning outside the ear canal of a subject, wherein said at least one thermoelectric device is configured to thermally stimulate the ear canal of the subject. 27. The stimulator of claim 26, wherein said heat sink further comprises an inner portion that is configured for positioning inside the ear canal of the subject, wherein said at least one thermoelectric device is mounted on said inner portion of said heat sink. 28. The stimulator of claim 27, wherein the heat sink outer portion comprises a plurality of fins. 29. The stimulator of claim 27, further comprising a sleeve that extends over said heat sink inner portion and said at least one thermoelectric device. 30. The stimulator of claim 26, wherein said heat sink comprises aluminum. 31. The stimulator of claim 26, wherein said heat sink has a weight between about 30 grams and about 70 grams. 32. A method for delivering caloric stimulation to a subject, the method comprising: positioning at least a portion of an in-ear stimulator in an ear canal of the subject, the earpiece comprising: (a) an earpiece configured to be at least partially insertable into the ear canal of the subject; and(b) at least one thermoelectric device thermally coupled to said earpiece and configured to heat or cool said earpiece to thereby thermally stimulate the ear canal of the subject;activating said in-ear stimulator to deliver a thermal stimulation to the ear canal of the subject; andreorienting a tilt angle of the subject to thereby modify a vestibular stimulation. 33. The method of claim 32, wherein said at least one thermal device comprises at least one thermoelectric device. 34. The method of claim 33, wherein activating said in-ear stimulator comprises delivering a time-varying thermal waveform to said at least one thermoelectric device such that said thermoelectric device effects corresponding temperature changes to said earpiece to deliver caloric stimulation to the subject. 35. The method of claim 34, wherein said stimulator further comprises a heat sink positioned in said earpiece internal cavity, wherein said heat sink is thermally coupled to said at least one thermoelectric device. 36. The method of claim 32, wherein said tilt angle is an angle of the subject's head with respect to a vertical orientation that is tilted forward between 75 and 120 degrees. 37. The method of claim 36, wherein activating said in-ear stimulator comprises delivering a constant caloric stimulation. 38. The method of claim 37, wherein the constant caloric stimulation is a cold caloric vestibular stimulation. 39. The method of claim 32, wherein said earpiece is conical in shape and said earpiece comprises a conical apex of the conical shape that has been blunted to form a dome-shaped point; wherein said earpiece comprises:a generally cylindrical base having opposite first and second ends, the base defining a longitudinal centerline; andan extended portion extending from the second end of the cylindrical base, wherein said dome-shaped point is offset from the longitudinal centerline. 40. The method of claim 32, wherein said in-ear simulator comprises a heat sink thermally coupled to said at least one thermoelectric device and configured for positioning outside the ear canal of a subject. 41. The method of claim 32, wherein said in-ear stimulator comprises first and second earpieces configured to be at least partially insertable into the right and left ear canal, respectively, of the subject and being configured to provide a thermal stimulation. 42. The method of claim 41, further comprising delivering a time-varying thermal waveform to said first and second earpieces to deliver caloric stimulation to the subject. 43. The method of claim 32, wherein activating said in-ear stimulator to deliver a thermal stimulation to the ear canal of the subject comprises changing a temperature of said in-ear stimulator at a slew rate of about 20° C./minute.
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