Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61M-031/00
A61K-031/436
A61K-031/337
A61L-029/16
A61L-031/16
A61L-029/08
A61M-025/10
A61F-002/82
A61K-009/00
A61M-016/04
출원번호
US-0193866
(2016-06-27)
등록번호
US-9937159
(2018-04-10)
발명자
/ 주소
Wang, Lixiao
출원인 / 주소
Lutonix, Inc.
대리인 / 주소
Dinsmore & Shohl LLP
인용정보
피인용 횟수 :
0인용 특허 :
248
초록▼
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The me
Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogs) and an additive.
대표청구항▼
1. A balloon catheter comprising a coating layer overlying an exterior surface of the balloon catheter, wherein: the balloon catheter is sized and configured for insertion into a passage of a respiratory system;the coating layer comprises a water insoluble drug and a combination of a first additive
1. A balloon catheter comprising a coating layer overlying an exterior surface of the balloon catheter, wherein: the balloon catheter is sized and configured for insertion into a passage of a respiratory system;the coating layer comprises a water insoluble drug and a combination of a first additive and a second additive;the water insoluble drug is chosen from paclitaxel and rapamycin;the first additive is chosen from PEG-20 sorbitan monolaurate, PEG-20 sorbitan monooleate, or N-octanoyl N-methylglucamine; andthe second additive is chosen from sorbitol, glucose, sucrose, lactobionic acid, gluconolactone, meglumine, lactic acid, gentisic acid, or combinations thereof. 2. The balloon catheter of claim 1, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is sorbitol. 3. The balloon catheter of claim 1, wherein: the drug is paclitaxel;the first additive is PEG-20 sorbitan monolaurate; andthe second additive is sorbitol. 4. The balloon catheter of claim 1, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is gluconolactone. 5. The balloon catheter of claim 1, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is lactobionic acid. 6. The balloon catheter of claim 1, wherein: the drug is paclitaxel;the first additive is PEG-20 sorbitan monolaurate; andthe second additive is gluconolactone. 7. The balloon catheter of claim 1, further comprising a top layer over the coating layer. 8. The balloon catheter of claim 1, further comprising an adherent layer between the exterior surface and the coating layer. 9. The balloon catheter of claim 8, wherein the adherent layer is chosen from polyolefins, polyisobutylene, ethylene-α-olefin copolymers, acrylic polymers and copolymers, polyvinyl chloride, polyvinyl methyl ether, polyvinylidene fluoride and polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polystyrene, polyvinyl acetate, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, Nylon 12, polycaprolactone, polyoxymethylenes, polyethers, epoxy resins, polyurethanes, rayon-triacetate, cellulose, cellulose acetate, cellulose butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, carboxymethyl cellulose, chitins, polylactic acid, polyglycolic acid, polylactic acid-polyethylene oxide copolymers, polyethylene glycol, polypropylene glycol, polyvinyl alcohol, and mixtures thereof. 10. The balloon catheter of claim 9, further comprising a top layer over the coating layer. 11. A method for treating a respiratory system, the method comprising: inserting into an airway a balloon catheter comprising a coating layer overlying an exterior surface of the balloon catheter, wherein: the coating layer comprises a drug, a first additive, and a second additive;the drug is chosen from paclitaxel and rapamycin,the first additive is chosen from PEG-20 sorbitan monolaurate, PEG-20 sorbitan monooleate, or N-octanoyl N-methylglucamine; andthe second additive is chosen from sorbitol, glucose, sucrose, lactobionic acid, gluconolactone, meglumine, lactic acid, gentisic acid, or combinations thereof;inflating the balloon catheter and releasing the drug to a wall of the airway;deflating the balloon; andwithdrawing the balloon catheter from the airway. 12. The method according to claim 11, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is sorbitol. 13. The method according to claim 11, wherein: the drug is paclitaxel;the first additive is PEG-20 sorbitan monolaurate; andthe second additive is sorbitol. 14. The method according to claim 11, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is gluconolactone. 15. The method according to claim 11, wherein: the first additive is PEG-20 sorbitan monolaurate; andthe second additive is lactobionic acid. 16. The method according to claim 11, wherein: the drug is paclitaxel;the first additive is PEG-20 sorbitan monolaurate; andthe second additive is gluconolactone. 17. The method according to claim 11, wherein the balloon catheter further comprises a top layer over the coating layer. 18. The method according to claim 11, wherein the balloon catheter further comprises an adherent layer between the exterior surface and the coating layer. 19. The method according to claim 18, wherein the adherent layer is chosen from polyolefins, polyisobutylene, ethylene-α-olefin copolymers, acrylic polymers and copolymers, polyvinyl chloride, polyvinyl methyl ether, polyvinylidene fluoride and polyvinylidene chloride, polyacrylonitrile, polyvinyl ketones, polystyrene, polyvinyl acetate, ethylene-methyl methacrylate copolymers, acrylonitrile-styrene copolymers, Nylon 12, polycaprolactone, polyoxymethylenes, polyethers, epoxy resins, polyurethanes, rayon-triacetate, cellulose, cellulose acetate, cellulose butyrate, cellophane, cellulose nitrate, cellulose propionate, cellulose ethers, carboxymethyl cellulose, chitins, polylactic acid, polyglycolic acid, polylactic acid-polyethylene oxide copolymers, polyethylene glycol, polypropylene glycol, polyvinyl alcohol, and mixtures thereof. 20. A balloon catheter comprising a coating layer overlying an exterior surface of the balloon catheter, wherein: the balloon catheter is sized and configured for insertion into a passage of a respiratory system;the coating layer comprises a water insoluble drug and a combination of a first additive and a second additive;the water insoluble drug is chosen from paclitaxel and rapamycin;the first additive is chosen from PEG-20 sorbitan monolaurate, PEG-20 sorbitan monooleate, or N-octanoyl N-methylglucamine; andthe second additive is chosen from sorbitol, glucose, sucrose, lactic acid, or combinations thereof.
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이 특허에 인용된 특허 (248)
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