초록 ▼

An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degr

An object is to provide a method of manufacturing a soft capsule that is enteric and excellent in formulation properties. An enteric soft capsule is manufactured by the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxyl pectin having a degree of amidation of 5 to 25%, and (b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. Preferably, the jelly strength of the gelatin is 160 to 300 Bloom, the degree of esterification of the low methoxy pectin is 20 to 40%, and the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin.

대표청구항 ▼

1. A method of manufacturing an enteric soft capsule, comprising the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of amidation of 5 to 25%, and(b) encapsulating capsule fills using the enteric capsule shell liqui

1. A method of manufacturing an enteric soft capsule, comprising the following steps (a) and (b): (a) preparing an enteric capsule shell liquid comprising gelatin and low methoxy pectin having a degree of amidation of 5 to 25%, and(b) encapsulating capsule fills using the enteric capsule shell liquid prepared in the step (a) by stamping. 2. The method of manufacturing an enteric soft capsule according to claim 1, wherein a jelly strength of the gelatin is 160 to 300 Bloom. 3. The method of manufacturing an enteric soft capsule according to claim 1, wherein a degree of esterification of the low methoxy pectin is 20 to 40%. 4. The method of manufacturing an enteric soft capsule according to claim 1, wherein the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 5. The method of manufacturing an enteric soft capsule according to claim 1, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 6. The method of manufacturing an enteric soft capsule according to claim 1, wherein the encapsulation is performed such that a thickness of the enteric capsule shell is 0.3 to 1.2 mm. 7. The method of manufacturing an enteric soft capsule according to claim 2, wherein a degree of esterification of the low methoxy pectin is 20 to 40%. 8. The method of manufacturing an enteric soft capsule according to claim 2, wherein the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 9. The method of manufacturing an enteric soft capsule according to claim 3, wherein the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 10. The method of manufacturing an enteric soft capsule according to claim 7, wherein the enteric capsule shell liquid comprises 30 to 35 parts by mass of the low methoxy pectin per 100 parts by mass of the gelatin. 11. The method of manufacturing an enteric soft capsule according to claim 2, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 12. The method of manufacturing an enteric soft capsule according to claim 3, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 13. The method of manufacturing an enteric soft capsule according to claim 4, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 14. The method of manufacturing an enteric soft capsule according to claim 7, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 15. The method of manufacturing an enteric soft capsule according to claim 8, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 16. The method of manufacturing an enteric soft capsule according to claim 9, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 17. The method of manufacturing an enteric soft capsule according to claim 10, wherein the low methoxy pectin is dispersed in glycerin and subsequently dissolved in hot water, then gelatin is added and dissolved, and the mixture is filtered and degassed under reduced pressure. 18. The method of manufacturing an enteric soft capsule according to claim 2, wherein the encapsulation is performed such that a thickness of the enteric capsule shell is 0.3 to 1.2 mm. 19. The method of manufacturing an enteric soft capsule according to claim 3, wherein the encapsulation is performed such that a thickness of the enteric capsule shell is 0.3 to 1.2 mm. 20. The method of manufacturing an enteric soft capsule according to claim 4, wherein the encapsulation is performed such that a thickness of the enteric capsule shell is 0.3 to 1.2 mm.