Devices, systems and methods for evaluation of hemostasis
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-030/96
G01N-033/86
B01L-003/00
G01N-029/024
G01N-029/22
G01N-035/00
출원번호
US-0644124
(2017-07-07)
등록번호
US-9977039
(2018-05-22)
발명자
/ 주소
Viola, Francesco
Walker, William F.
Browne, Gregory V.
Magyar, Robert S.
Hansen, Bjarne
Denny, Christopher G.
출원인 / 주소
HemoSonics LLC
대리인 / 주소
Meunier Carlin & Curfman LLC
인용정보
피인용 횟수 :
0인용 특허 :
96
초록
Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
대표청구항▼
1. A device comprising: a housing;a plurality of test chambers, wherein the plurality of test chambers includes at least a first test chamber and a second test chamber that are each at least partially defined by the housing, wherein the first test chamber and the second test chamber are each designe
1. A device comprising: a housing;a plurality of test chambers, wherein the plurality of test chambers includes at least a first test chamber and a second test chamber that are each at least partially defined by the housing, wherein the first test chamber and the second test chamber are each designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a reagent or combination of reagents, wherein a first reagent or combination of reagents in the first test chamber is different than a second reagent or combination of reagents in the second test chamber; anda fluid pathway comprising a plurality of channels, each defined at least in part by the housing, wherein the fluid pathway includes an inlet, defined at least in part by the housing, through which the test sample is introduced into the device, wherein at least one channel of the plurality of channels is in communication with the inlet and with the first test chamber and the second test chamber to deliver a portion of the test sample to each of the first test chamber and the second test chamber, and wherein the fluid pathway includes a first port, defined at least in part by the housing, in communication with a channel of the fluid pathway and from which a pressure gradient when applied from a source external to the first port draws the test sample through the at least one channel of the fluid pathway and into at least one of the test chambers, wherein the at least one channel of the fluid pathway includes an inlet channel, a first channel, and a second channel, wherein the inlet channel is in communication with the inlet, wherein the first channel is in communication with the inlet channel and at least with the first test chamber, and wherein the second channel is in communication with the inlet channel and at least with the second test chamber,wherein the housing includes a thermally conductive wall configured to allow the test sample to be heated, the thermally conductive wall having an outer surface area and an inner surface area;wherein the fluid pathway includes a portion at least partially defined by the inner surface area of the thermally conductive wall and the outer surface area of the thermally conductive wall is shaped to be held in at least partially conforming contact with or in close proximity to a heater to allow adjustment of a temperature of the test sample flowing through the portion at least partially defined by the inner surface area of the thermally conductive wall; andwherein the device can be used with an interrogation device to measure at least one viscoelastic property of the test sample. 2. The device of claim 1, wherein the portion at least partially defined by the outer surface area of the thermally conductive wall is designed to be held against a heater external to the device. 3. The device of claim 2, wherein the device is designed to allow the test sample to reach about 37° C. in the first test chamber and the second test chamber. 4. The device of claim 3, wherein the portion at least partially defined by the inner surface area of the thermally conductive wall comprises a thermally conductive polymer that has a thermal conductivity that exceeds 0.123 W/m ° K. 5. The device of claim 1, further comprising a second port, defined at least in part by the housing, and from which a pressure gradient when applied from a source external to the second port causes the test sample to move from an external vessel through the inlet and the at least one channel of the fluid pathway and into the housing. 6. The device of claim 5, wherein the device is designed such that a vacuum can be applied at the second port to introduce the test sample into the inlet and propel the sample into the at least one channel of the fluid pathway. 7. The device of claim 6, wherein the inlet is designed such that the external vessel can establish fluid communication to allow the inlet to receive the test sample. 8. The device of claim 7, wherein the device is designed to prevent the test sample from leaving through the first port or the second port. 9. The device of claim 8, wherein the fluid pathway can be coupled with a sample container to allow a portion of the test sample to be collected in the sample container after it has moved through the housing. 10. The device of claim 1, wherein the first port is configured, when applied with the pressure gradient, to draw the test sample from an external vessel through the inlet and the at least one channel of the fluid pathway and into the housing. 11. The device of claim 1, wherein the device is designed to prevent the test sample from leaving through the first port. 12. The device of claim 1, wherein the housing is designed to allow a fluid level to be monitored optically. 13. The device of claim 1, further comprising a magnetic stirrer. 14. The device of claim 1, wherein at least one of the plurality of test chambers is designed for interrogation by acoustic pulses. 15. The device of claim 14, wherein at least one of the plurality of test chambers comprises a sound focusing assembly comprising a rigid substrate and an elastomeric couplant positioned relative to the rigid substrate, wherein the rigid substrate and the elastomeric couplant are permeable by sound. 16. The device of claim 14, wherein the first test chamber includes the first reagent or combination or reagents and the second test chamber includes the second reagent or combination or reagents prior to receiving the test sample of blood therein. 17. The device of claim 16, wherein one of more of the reagents are lyophilized as lyophilized beads. 18. The device of claim 1, wherein the housing is configured for single use as part of a disposable cartridge. 19. The device of claim 1, wherein one of more of the reagents are lyophilized as lyophilized beads. 20. The device of claim 1, further comprising a third test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a third reagent or combination of reagents, wherein the third reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 21. The device of claim 20, further comprising a fourth test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a fourth reagent or combination of reagents, wherein the fourth reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 22. The device of claim 1, wherein the device is designed to evaluate at least one component of hemostasis selected from the group consisting of initial and final fibrin formation, fibrin and platelet activity, rate of fibrin polymerization, and clot dissolving process. 23. The device of claim 1, wherein the device is designed to evaluate at least one parameter selected from the group consisting of an intrinsic pathway coagulation factors index, an extrinsic pathway coagulation factors index, a platelet index, a fibrinogen index, and a fibrinolysis index. 24. The device of claim 23, wherein the first test chamber and the second test chamber are designed to be interrogated to measure clot stiffness, and a platelet index can be determined from a differential between the clot stiffness measurement in the first test chamber and the clot stiffness measurement in the second test chamber. 25. The device of claim 23, wherein the device is designed to evaluate a fibrinolysis index. 26. A device comprising: a housing;a plurality of test chambers, wherein the plurality of test chambers includes at least a first test chamber and a second test chamber that are each at least partially defined by the housing, wherein the first test chamber and the second test chamber are each designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a reagent or combination of reagents, wherein a first reagent or combination of reagents in the first test chamber is different than a second reagent or combination of reagents in the second test chamber; anda fluid pathway comprising a plurality of channels, each defined at least in part by the housing, wherein the fluid pathway includes an inlet, defined at least in part by the housing, through which the test sample is introduced into the device, wherein at least one channel of the plurality of channels is in communication with the inlet and with the first test chamber and the second test chamber to deliver a portion of the test sample to each of the first test chamber and the second test chamber, and wherein the fluid pathway includes a first port, defined at least in part by the housing, in communication with a channel of the fluid pathway and from which a pressure gradient when applied from a source external to the first port draws the test sample through the fluid pathway and into at least one of the test chambers, wherein the at least one channel of the fluid pathway includes an inlet channel, a first channel, and a second channel, wherein the inlet channel is in communication with the inlet, wherein the first channel is in communication with the inlet channel and at least with the first test chamber, and wherein the second channel is in communication with the inlet channel and at least with the second test chamber,wherein at least a portion of the housing is thermally conductive to allow the test sample to be heated,wherein the first reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof,wherein the second reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof,wherein at least one of the first reagent or combination of reagents and the second reagent or combination of reagents activates the test sample via the extrinsic pathway of coagulation,wherein the second reagent or combination of reagents further includes one or both of abciximab and cytochalasin D, andwherein the device can be used with an interrogation device to measure at least one viscoelastic property of the test sample. 27. The device of claim 26, further comprising a third test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a third reagent or combination of reagents, wherein the third reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 28. The device of claim 27, further comprising a fourth test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a fourth reagent or combination of reagents, wherein the fourth reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 29. The device of claim 28, wherein the at least one channel includes the inlet channel, the first channel, the second channel, a third channel, and a fourth channel, wherein the third channel is in communication with the inlet channel and at least with the third test chamber, andwherein the fourth channel is in communication with the inlet channel and at least with the fourth test chamber. 30. The device of claim 26, wherein the device is designed to evaluate at least one component of hemostasis selected from the group consisting of initial and final fibrin formation, fibrin and platelet activity, rate of fibrin polymerization, and clot dissolving process. 31. The device of claim 26, wherein the device is designed to evaluate at least one parameter selected from the group consisting of an intrinsic pathway coagulation factors index, an extrinsic pathway coagulation factors index, a platelet index, a fibrinogen index, and a fibrinolysis index. 32. The device of claim 31, wherein the first test chamber and the second test chamber are designed to be interrogated to measure clot stiffness, and a platelet index can be determined from a differential between the clot stiffness measurement in the first test chamber and the clot stiffness measurement in the second test chamber. 33. The device of claim 31, wherein the device is designed to evaluate a fibrinolysis index. 34. The device of claim 26, wherein the housing includes a thermally conductive wall configured to allow the test sample to be heated, the thermally conductive wall having an outer surface area and an inner surface area,wherein the fluid pathway includes a portion at least partially defined by the inner surface area of the thermally conductive wall and the outer surface area of the thermally conductive wall is shaped to be held in at least partially conforming contact with or in close proximity to a heater to allow adjustment of a temperature of the test sample flowing through the portion at least partially defined by the inner surface area of the thermally conductive wall, andwherein the portion at least partially defined by the outer surface area of the thermally conductive wall is designed to be held against a heater external to the device. 35. The device of claim 34, wherein the device is designed to allow the test sample to reach about 37° C. in the first test chamber and the second test chamber. 36. The device of claim 35, wherein the portion at least partially defined by the inner surface area of the thermally conductive wall comprises a thermally conductive polymer that has a thermal conductivity that exceeds 0.123 W/m ° K. 37. The device of claim 26, further comprising a second port, defined at least in part by the housing, and from which a pressure gradient when applied from a source external to the second port causes the test sample to move from an external vessel through the inlet and the at least one channel of the fluid pathway and into the housing. 38. The device of claim 37, wherein the device is designed such that a vacuum can be applied at the second port to introduce the test sample into the inlet and propel the sample into the at least one channel of the fluid pathway. 39. The device of claim 38, wherein the inlet is designed such that the external vessel can establish fluid communication to allow the inlet to receive the test sample. 40. The device of claim 39, wherein the device is designed to prevent the test sample from leaving through the first port or the second port. 41. The device of claim 40, wherein the fluid pathway can be coupled with a sample container to allow a portion of the test sample to be collected in the sample container after it has moved through the housing. 42. The device of claim 26, wherein the first port is configured, when applied with the pressure gradient, to draw the test sample from an external vessel through the inlet and the at least one channel of the fluid pathway and into the housing. 43. The device of claim 26, wherein the device is designed to prevent the test sample from leaving through the first port. 44. The device of claim 26, wherein the housing is designed to allow a fluid level to be monitored optically. 45. The device of claim 26, further comprising a magnetic stirrer. 46. The device of claim 26, wherein at least one of the plurality of test chambers is designed for interrogation by acoustic pulses. 47. The device of claim 46, wherein at least one of the plurality of test chambers comprises a sound focusing assembly comprising a rigid substrate and an elastomeric couplant positioned relative to the rigid substrate, wherein the rigid substrate and the elastomeric couplant are permeable by sound. 48. The device of claim 26, wherein the first test chamber includes the first reagent or combination or reagents and the second test chamber includes the second reagent or combination or reagents prior to receiving the test sample of blood therein. 49. The device of claim 26, wherein one of more of the reagents are lyophilized as lyophilized beads. 50. The device of claim 26, wherein the housing is configured for single use as part of a disposable cartridge. 51. A device comprising: a housing;a plurality of test chambers, wherein the plurality of test chambers includes at least a first test chamber, a second test chamber, and a third test chamber that are each at least partially defined by the housing, wherein each of the first test chamber, the second test chamber, and the third test chamber are designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a reagent or combination of reagents, wherein a first reagent or combination of reagents, a second reagent or combination of reagents, and a third reagent or combination of reagents each activate the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof, and wherein the first reagent or combination of reagents is different than the second reagent or combination of reagents; anda fluid pathway comprising a plurality of channels, each defined at least in part by the housing,wherein the fluid pathway includes an inlet, defined at least in part by the housing, through which the test sample is introduced into the device, wherein at least one channel of the plurality of channels is in communication with the inlet and with the first test chamber, the second test chamber, and the third test chamber to deliver a portion of the test sample to each of the first test chamber, the second test chamber, and the third test chamber, wherein the fluid pathway includes a first port, defined at least in part by the housing, in communication with a channel of the fluid pathway and from which a pressure gradient when applied from a source external to the first port draws the test sample through the fluid pathway and into at least one of the test chambers wherein the at least one channel of the fluid pathway includes an inlet channel, a first channel, and a second channel, wherein the inlet channel is in communication with the inlet, wherein the first channel is in communication with the inlet channel and at least with the first test chamber, and wherein the second channel is in communication with the inlet channel and at least with the second test chamber,wherein the fluid pathway includes a second port, defined at least in part by the housing, in communication with a channel of the fluid pathway and from which a pressure gradient when applied from a source external to the second port draws the test sample to move from an external vessel through the inlet and the at least one channel of the fluid pathway into the housing, andwherein the fluid pathway includes a portion designed to be held against a heater to allow adjustment of a temperature of the test sample flowing through the portion,wherein the first port and/or the second port prevents the test sample from leaving the device,wherein at least a portion of the housing is designed to be thermally conductive to allow the test sample to reach about 37° C. in the test chambers; andwherein the device is configured for use with an interrogation device to measure at least one viscoelastic property of the test sample. 52. A system for evaluation of hemostasis, the system comprising: a consumable cartridge configured to be positioned in an analysis system, the consumable cartridge comprising a cartridge housing;a plurality of test chambers, wherein the plurality of test chambers includes at least a first test chamber and a second test chamber that are each at least partially defined by the cartridge housing, wherein the first test chamber and the second test chamber are each designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a reagent or combination of reagents, wherein a first reagent or combination of reagents in the first test chamber is different than a second reagent or combination of reagents in the second test chamber; anda fluid pathway comprising a plurality of channels, each defined at least in part by the cartridge housing, wherein the fluid pathway includes an inlet, defined at least in part by the cartridge housing, through which the test sample is introduced into the consumable cartridge, wherein at least one channel of the plurality of channels is in communication with the inlet and with the first test chamber and the second test chamber to deliver a portion of the test sample to each of the first test chamber and the second test chamber, and wherein the fluid pathway includes a first port, defined at least in part by the cartridge housing, in communication with a channel of the fluid pathway and from which a pressure gradient when applied from a source external to the first port draws the test sample through the at least one channel of the fluid pathway and into at least one of the test chambers, anda heat exchanger, and a temperature control coupled thereto, designed to allow the temperature of the test sample to be adjusted before analysis in the test chambers;an interrogation device designed to measure at least one viscoelastic property of the test sample;a pressure control designed to apply the pressure gradient that causes the test sample to flow through the fluid pathway and into the test chambers; andan analysis system, the analysis system comprising: an analysis system housing having a pocket designed to receive the consumable cartridge, the pocket comprising an actuator system that allows the heat exchanger, the interrogation device, and the pressure control to be positioned adjacent to the consumable cartridge. 53. The system of claim 52, wherein the cartridge housing includes a thermally conductive wall configured to allow the test sample to be heated, the thermally conductive wall having an outer surface area and an inner surface area,wherein the fluid pathway includes a portion at least partially defined by the inner surface area of the thermally conductive wall and the outer surface area of the thermally conductive wall is shaped to be held in at least partially conforming contact with or in close proximity to a heater to allow adjustment of a temperature of the test sample flowing through the portion at least partially defined by the inner surface area of the thermally conductive wall, andwherein the portion at least partially defined by the outer surface area of the thermally conductive wall is designed to be held against a heater external to the device. 54. The system of claim 53, wherein the system is designed to allow the test sample to reach about 37° C. in the first test chamber and the second test chamber. 55. The system of claim 54, wherein the portion at least partially defined by the inner surface area of the thermally conductive wall comprises a thermally conductive polymer that has a thermal conductivity that exceeds 0.123 W/m ° K. 56. The system of claim 52, further comprising a second port, defined at least in part by the housing, and from which a pressure gradient when applied from a source external to the second port causes the test sample to move from an external vessel through the inlet and the at least one channel of the fluid pathway and into the cartridge housing. 57. The system of claim 56, wherein the system is designed such that a vacuum can be applied at the second port to introduce the test sample into the inlet and propel the sample into the at least one channel of the fluid pathway. 58. The system of claim 57, wherein the inlet is designed such that the external vessel can establish fluid communication to allow the inlet to receive the test sample. 59. The system of claim 52, wherein the fluid pathway can be coupled with a sample container to allow a portion of the test sample to be collected in the sample container after it has moved through the cartridge housing. 60. The system of claim 52, wherein the first port is configured, when applied with the pressure gradient, to draw the test sample from an external vessel through the inlet and the at least one channel of the fluid pathway and into the cartridge housing. 61. The system of claim 52, wherein the device is designed to prevent the test sample from leaving through the first port. 62. The system of claim 52, wherein the cartridge housing is designed to allow a fluid level to be monitored optically. 63. The system of claim 52, further comprising a magnetic stirrer. 64. The system of claim 52, wherein the first test chamber includes the first reagent or combination or reagents and the second test chamber includes the second reagent or combination or reagents prior to receiving the test sample of blood therein. 65. The system of claim 52, further comprising a third test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a third reagent or combination of reagents, wherein the third reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 66. The system of claim 65, further comprising a fourth test chamber designed to be interrogated to determine a hemostatic parameter of a test sample of blood that is received therein and a fourth reagent or combination of reagents, wherein the fourth reagent or combination of reagents activates the test sample via an intrinsic pathway of coagulation, an extrinsic pathway of coagulation, or a combination thereof. 67. The system of claim 52, wherein the consumable cartridge is designed to evaluate at least one component of hemostasis selected from the group consisting of initial and final fibrin formation, fibrin and platelet activity, rate of fibrin polymerization, and clot dissolving process. 68. The system of claim 52, wherein the consumable cartridge is designed to evaluate at least one parameter selected from the group consisting of an intrinsic pathway coagulation factors index, an extrinsic pathway coagulation factors index, a platelet index, a fibrinogen index, and a fibrinolysis index. 69. The system of claim 68, wherein the first test chamber and the second test chamber are designed to be interrogated to measure clot stiffness, and a platelet index can be determined from a differential between the clot stiffness measurement in the first test chamber and the clot stiffness measurement in the second test chamber. 70. The system of claim 68, wherein the consumable cartridge is designed to evaluate a fibrinolysis index. 71. The system of claim 52, wherein at least one of the plurality of test chambers is designed for interrogation by acoustic pulses. 72. The system of claim 71, wherein at least one of the plurality of test chambers comprises a sound focusing assembly comprising a rigid substrate and an elastomeric couplant positioned relative to the rigid substrate, wherein the rigid substrate and the elastomeric couplant are permeable by sound. 73. The system of claim 52, wherein the first test chamber includes the first reagent or combination or reagents and the second test chamber includes the second reagent or combination or reagents prior to receiving the test sample of blood therein. 74. The device of claim 73, wherein one of more of the reagents are lyophilized as lyophilized beads. 75. The system of claim 52, wherein the cartridge housing is configured for single use as part of a disposable cartridge. 76. The device of claim 52, wherein the at least one channel of the fluid pathway includes an inlet channel, a first channel, and a second channel, wherein the inlet channel is in communication with the inlet,wherein the first channel is in communication with the inlet channel and at least with the first test chamber, andwherein the second channel is in communication with the inlet channel and at least with the second test chamber. 77. The system of claim 76, wherein one of more of the reagents are lyophilized as lyophilized beads.
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Friemel Barry H. (Issaquah WA) Weng Lee (Bellevue WA) Teo Tat-Jin (Redmond WA), 3-Dimensional compound ultrasound field of view.
Dymling Stephan (Rudbecksgatan 113 S-216 22 MalmSEX) Hertz Tomas (Filippavgen 2 D S-222 41 Lund SEX) Lindstrm Kjell (N. Skogsvgen 3 S-236 00 Hliviken SEX) Persson Hans W. (Thulehemsvgen 3 S-223 67 Lu, Acoustic method for measuring properties of a mobile medium.
Ying Hao (League City TX) Hartley Craig J. (Houston TX), Apparatus and method for noninvasive doppler ultrasound-guided real-time control of tissue damage in thermal therapy.
LeVeen Eric G. (321 Confederate Cir. Charleston SC 29407) LeVeen Robert F. (312 Lombard St. Philadelphia PA 19147), Apparatus and method of quantifying hemostasis using oscillations from a transducer immersed in the blood sample.
Barone David (Sharon MA) Herrig Russell (Sharon MA) Kaleskas Edward (Jefferson MA) Porreca Ronald (Needham MA) Stenfors Alan L. (Scituate MA) Vandor Robert (Walpole MA) Medberry Joseph M. (Seekonk MA, Blood processing method and apparatus with disposable cassette.
Barone David (Sharon MA) Herrig Russell (Sharon MA) Medberry Joseph M. (Seekonk MA) Volpini Paul M. (Quincy MA) Plante Joseph R. (Ashland MA), Blood processing method and apparatus with disposable cassette.
Hillman Robert S. (Cupertino) Cobb Michael E. (Sunnyvale) Allen Jimmy D. (Los Altos) Gibbons Ian (Menlo Park) Ostoich Vladimir E. (San Jose) Winfrey Laura J. (Belmont CA), Capillary flow device.
McCormick Francis P. (Albany CA) Koths Kirston E. (El Cerrito CA) Halenbeck Robert F. (San Rafael CA) Trahey Mary M. (Oakland CA), Compositions for detecting ras gene proteins and cancer therapeutics.
McCormick Francis P. (Berkeley CA) Koths Kirston E. (El Cerrito CA) Halenbeck Robert F. (San Rafael CA) Trahey Mary M. (San Carlos CA), Compositions for detecting ras gene proteins and cancer therapeutics.
McCormick Frank P. (Albany CA) Koths Kirston E. (El Cerrito CA) Halenbeck Robert F. (San Rafael CA) Trahey Mary M. (Oakland CA), Compositions for detecting ras gene proteins and cancer therapeutics.
Scott M. Clark ; Robert H. Suva ; Michael R. Kepron ; Stanislaw Barski, Jr. ; Erwin F. Workman, Jr., Device and method for integrated diagnostics with multiple independent flow paths.
Zeng, Kefeng; Ong, Keat Ghee; Yang, Xiping; Grimes, Craig A., Impedance analysis technique for frequency domain characterization of magnetoelastic sensor element by measuring steady-state vibration of element while undergoing constant sine-wave excitation.
Cespedes Eduardo Ignacio ; Lancee Charles Theodoor,NLX ; Van Der Steen Antonius Franciscus Wilhelmus,NLX ; Li Wenguang ; Bom Nicolaas,NLX, Measurement of volumetric fluid flow and its velocity profile.
Cespedes, Eduardo Ignacio; Lancee, Charles Theodoor; Wilhemus Van Der Steen, Antonius Franciscus; Li, Wenguang; Bom, Nicolaas, Measurement of volumetric fluid flow and its velocity profile.
Trahey Gregg E. (Hillsborough NC) Ng Gary C-H (Durham NC) Walker William F. (Durham NC) Freiburger Paul D. (Issaquah WA), Method and apparatus for abberation correction in the presence of a distributed aberrator.
Braun ; Sr. Walter J. (7884 S. Argonne Ct. Aurora CO 80016) Boiarski Anthony A. (2615 Henthorn Rd. Upper Arlington OH 43221) Braun ; Jr. Walter J. (7884 S. Argonne Ct. Aurora CO 80016) Braun Steven P, Method and apparatus for detecting viscosity changes in fluids.
Trahey Gregg E. (Hillsborough NC) Kornguth Phyllis (Durham NC) Nightingale Kathryn (Durham NC) Walker William F. (Durham NC), Method and apparatus for distinguishing between solid masses and fluid-filled cysts.
Kathryn R. Nightingale ; Gregg E. Trahey ; Roger W. Nightingale ; Mark L. Palmeri, Method and apparatus for the identification and characterization of regions of altered stiffness.
Trahey, Gregg E.; Nightingale, Kathryn R.; Nightingale, Roger W.; Palmeri, Mark, Method and apparatus for the identification and characterization of regions of altered stiffness.
Spillert Charles R. (West Orange NJ) Suval William A. (Liberty Corners NJ) Lazaro Eric J. (Jersey City NJ), Method for determining the existance and/or the monitoring of a pathological condition in a mammal.
Spillert Charles R. (West Orange NJ) Suval William A. (Liberty Corners NJ) Lazaro Eric J. (Jersey City NJ), Method for determining the existence and/or the monitoring of a pathological condition in a mammal and a test kit theref.
Aiken, Jennifer C.; Henderson, Jon H.; DeBiase, Barbara A., Method for performing activated clotting time test with reduced sensitivity to the presence of aprotinin and for assessing aprotinin sensitivity.
Cohen-Bacrie Claude,FRX ; Bruni Fabrice,FRX ; Bonnefous Odile,FRX, Method of and apparatus for echographic determination of the viscosity and the pressure gradient in a blood vessel.
Spillert Charles R. (West Orange NJ) Suval William D. (Liberty Corners NJ) Lazaro Eric J. (Jersey City NJ), Method of determining the existence and/or the monitoring of a pathological condition in a mammal.
Carr, Jr.,Marcus E.; Krischnaswami,Ashok; Martin,Erika, Method of using platelet contractile force and whole blood clot elastic modulus as clinical markers.
Walker, William F.; Viola, Francesco; Mauldin, F. William, Methods, apparatus, or systems for characterizing physical property in non-biomaterial or bio-material.
Trahey, Gregg E.; Nightingale, Kathryn R.; Nightingale, Roger W.; McAleavey, Stephen, Methods, systems, and computer program products for imaging using virtual extended shear wave sources.
Nightingale,Kathryn R.; Trahey,Gregg E., Methods, systems, and computer program products for ultrasound measurements using receive mode parallel processing.
Gavin Michael (Warren NJ) Cimini Catherine M. (Somerset NJ) Huang Ming (Milltown NJ) Kuklo ; Jr. Anthony (Bridgewater NJ) Mawhirt James A. (Brooklyn NY) Marcelino Eduardo (Edison NJ) Simone Albert (F, Portable test apparatus and associated method of performing a blood coagulation test.
Ries Loriann L. (Durham NC) Smith Stephen W. (Durham NC) Trahey Gregg E. (Hillsborough NC), Two-dimensional phase correction using a deformable ultrasonic transducer array.
Trahey Gregg E. (Hillsborough NC) Freiburger Paul D. (Dubuque IA) Smith Stephen W. (Durham NC) Worrell Stewart S. (Lexington VA), Ultrasonic phased array imaging system with high speed adaptive processing using selected elements.
Smith Stephen W. ; Trahey Gregg E. ; Goldberg Richard L. ; Davidsen Richard E., Ultrasound transducer array with transmitter/receiver integrated circuitry.
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