Peroxide formulations and methods and applicators for using the same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-008/00
A61K-033/40
A61K-031/045
A61K-009/00
A61K-008/34
A61Q-019/00
A61Q-019/08
A61K-047/10
A61K-008/22
A61M-035/00
A61K-009/08
출원번호
US-0591894
(2017-05-10)
등록번호
US-9980983
(2018-05-29)
발명자
/ 주소
Shanler, Stuart D.
Powala, Christopher
Phillips, Christopher
Beger, Brian
Greenaway Evans, Charles Rodney
Lim, Sian Tiong
Brown, Marc Barry
Botta, Michael A.
Nagler, Thomas
출원인 / 주소
ACLARIS THERAPEUTICS, INC.
대리인 / 주소
Pepper Hamilton LLP
인용정보
피인용 횟수 :
0인용 특허 :
30
초록▼
Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosu
Embodiments are directed to a stable composition comprising stabilized hydrogen peroxide and 2-propanol and applicators configured to store, dispense, and apply such stable compositions. Such compositions may be used to treat skin conditions such as warts, condyloma accuminatum, molluscum contagiosum, acrochordons, seborrheic keratosis, or a combination thereof. Some embodiments also describe take home compositions, in office compositions, over-the-counter compositions, and kits for the use of such compositions.
대표청구항▼
1. A method of treating seborrheic keratosis in a human in need thereof, comprising topically administering to the human a composition comprising about 40% w/w of stabilized hydrogen peroxide, wherein the compound used to stabilize the hydrogen peroxide comprises stannate, sodium pyrophosphate, orga
1. A method of treating seborrheic keratosis in a human in need thereof, comprising topically administering to the human a composition comprising about 40% w/w of stabilized hydrogen peroxide, wherein the compound used to stabilize the hydrogen peroxide comprises stannate, sodium pyrophosphate, organophosphonate, nitrate, phosphoric acid, colloidal silicate, or a combination thereof. 2. The method of claim 1, wherein the composition is administered once to the human. 3. The method of claim 1, wherein the composition is administered twice to the human. 4. The method of claim 3, wherein the second administration of the composition to the human occurs about 3 weeks after the first administration of the composition to the human. 5. The method of claim 1, wherein the composition has a surface tension of about 42 mN·m−1 to about 55 mN·m−1 at 37° C. 6. The method of claim 1, wherein the composition is stable for at least two years at 5° C., at least one year at 30° C., at least 6 months at 40° C., or a combination thereof. 7. The method of claim 1, wherein the composition has a mean steady state release of hydrogen peroxide between 0.5 hours and 4 hours of between about 1000 μg/cm2/hour and about 1750 μg/cm2/hour. 8. The method of claim 1, wherein the composition has a mean redox potential of about 415 mV to about 430 mV. 9. The method of claim 1, wherein the composition has a pH of about 3.5 to about 4. 10. The method of claim 1, wherein the composition is a solution. 11. The method of claim 1, wherein the composition is a gel. 12. The method of claim 1, wherein administering the composition comprises contacting the seborrheic keratosis with an applicator selected from the group consisting of a sponge, a swab, a foam tipped stick, a cotton ball, a brush, a woven or non-woven fabric, roller, gauze, a glove, a pen-type applicator, a flocked, doe-foot applicator or a combination thereof. 13. The method of claim 1, wherein administering the composition comprises contacting the seborrheic keratosis with a tip of an applicator, wherein the applicator comprises: a frangible ampoule having the composition disposed therein,an applicator body having the frangible ampoule arranged therein;an applicator hub in fluid communication with the applicator body;the tip arranged at a proximal end of the applicator hub; anda filter arranged between the frangible ampoule and the tip. 14. The method of claim 13, wherein administering the composition comprises controlling a flow rate of the topical composition out of the tip by varying a squeezing force applied to the exterior surface of the applicator body. 15. The method of claim 13, wherein administering the composition comprises contacting the tip with the seborrheic keratosis whereby the topical composition dispenses through the tip onto the targeted lesion. 16. The method of claim 13, wherein administering the composition further comprises applying pressure to a pressure area arranged on an outer surface of the applicator body causing the frangible ampoule to rupture. 17. The method of claim 13, wherein administering the composition comprises causing the frangible ampoule to rupture and release the topical composition through the tip; and contacting the tip to the seborrheic keratosis. 18. The method of claim 1, wherein the composition further comprises a surface tension modifying agent. 19. The method of claim 1, wherein the composition further comprises an alcohol. 20. The method of claim 1, wherein the composition further comprises a stabilizer. 21. The method of claim 1, wherein the composition further comprises a gelling agent. 22. The method of claim 1, wherein the composition further comprises an excipient. 23. The method of claim 1 further including debriding the seborrheic keratosis. 24. The method of claim 1, wherein no additional active agent is needed to treat the seborrheic keratosis. 25. The method of claim 1, wherein no additional therapeutic intervention is needed to treat the seborrheic keratosis.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (30)
Cragoe ; Jr. ; Edward J. ; Bicking ; John B. ; Smith ; Robert L., 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins.
Cragoe ; Jr. Edward J. (Lansdale PA) Bicking John B. (Lansdale PA) Smith Robert L. (Lansdale PA), 9-Thia- and oxothia- and 9-dioxothia-11,12-seco-prostaglandins and processes.
Yu Ruey J. (4 Lindenwold Ave. Ambler PA 19002) Van Scott Eugene J. (1138 Sewell La. Rydal PA 19046), Alpha hydroxyacids, alpha ketoacids and their use in treating skin conditions.
Jacquet Bernard (Antony FRX) Gaetani Quintino (Bondy FRX) Hocquaux Michel (Paris FRX), Anhydrous solution of hydrogen peroxide in an organic solvent and the use of the same in therapeutic and cosmetic formul.
King John R. (8414 Greenham Dr. San Antonio TX 78239), Composition for treating acne, method of manufacturing said composition, and method of treating skin.
Herzog Paul (37-39 ; route du Monteliza Saint-Legier CHX 1806), Composition of vitamin A, glucose and hydrogen peroxide for cosmetic or pharmaceutical use.
Herzog Paul (Avenue de Rolliez 10 Vevey CH) Herzog-Thomander Karin (Avenue de Rolliez 10 Vevey CH), Disinfectant for the surface of human body parts containing hydrogen peroxide.
Maschler Harald (Nordstemmen PA DEX) Christensen ; IV Siegfried B. (King of Prussia PA), Phenyl-substituted cycloalkenyl compounds useful as PDE IV inhibitors.
Breitenbach Jorg,DEX ; Fussnegger Bernhard,DEX ; Lang Siegfried,DEX, Topical Products as prophylactic of curative agents for bacterial skin infections.
Minns Charles R. (Williamsburg VA) Blount Timothy W. (Poquoson VA) Varner ; Jr. Thomas L. (Williamsburg VA), Volatile carpet sanitizing shampoo containing hydrogen peroxide.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.