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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0503367 (2006-08-10) |
등록번호 | US-9986942 (2018-06-05) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 948 |
Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device
Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.
1. An analyte sensing device for detecting an analyte in a host, comprising: a transcutaneous continuous sensor configured to measure a clinically useful analyte concentration in a tissue of a host for a time period from one day to fifteen days post implantation, the sensor comprising: a sensor conf
1. An analyte sensing device for detecting an analyte in a host, comprising: a transcutaneous continuous sensor configured to measure a clinically useful analyte concentration in a tissue of a host for a time period from one day to fifteen days post implantation, the sensor comprising: a sensor configured to measure an analyte in a host;a sensing membrane located over the sensor; anda biointerface membrane disposed on the sensing membrane, wherein the biointerface membrane is configured to interface with biological fluid, wherein the biointerface membrane has a dry thickness from 0.2 microns to 5 microns, wherein the biointerface membrane comprises a material that has from 20 wt. % to about 80 wt. % water during sensor use,wherein the sensor has a sensitivity of 1 pA/mg/dL to 100 pA/mg/dL during a sensor session. 2. The device of claim 1, wherein the biointerface membrane comprises a bioactive agent, wherein the bioactive agent comprises a substance that releases into the tissue upon implantation into the host, wherein the bioactive agent suppresses wound healing by promoting irritation and/or inflammation around at least a portion of the sensor in vivo. 3. The device of claim 1, wherein the biointerface membrane comprises a shape-memory material configured to be applied to the sensor in a first configuration, wherein after insertion into the tissue of the host the shape-memory material is configured to transform to a second configuration. 4. The device of claim 1, wherein the biointerface membrane comprises an irritating architecture configured to promote fluid bulk surrounding at least a portion of the sensor in vivo by promoting an irritation and/or inflammation surrounding the sensor in vivo, thereby discouraging cells from stabilizing and building up an ordered, fibrous capsule during the time period.
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