[특허]Sustained release eye drop formulations

[미국특허] Sustained release eye drop formulations 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-047/22 A61K-031/375 A61K-031/522 A61K-031/4196 A61K-031/5575 A61K-031/436 A61K-045/06 A61K-047/14 A61K-047/12 A61K-031/573 A61K-038/13 A61K-009/00 A61K-009/107
출원번호	US-0963574 (2013-08-09)
등록번호	US-9993558 (2018-06-12)
발명자 / 주소	Wong, Vernon G. Wood, Louis L.
출원인 / 주소	Ramscor, Inc.
대리인 / 주소	Wiley Rein LLP
인용정보	피인용 횟수 : 0 인용 특허 : 73

초록 ▼

This invention provides for biocompatible, biodegradable eye drop pharmaceutical formulations useful for the treatment of ocular indications. In particular, tocopherols and their esters of low water solubility, notably α-tocopheryl acetate, are exceptional vehicles for biocompatible, nonirritating t

대표청구항 ▼

1. A unit dose of a pharmaceutical eye drop formulation for the sustained release of an anti-inflammatory agent for the treatment of inflammation in the eye wherein said pharmaceutical eye drop formulation comprises a homogeneous mixture of: (a) 10% to 15% (wt.) of at least one anti-inflammatory agent selected from dexamethasone, triamcinolone, or a derivative, analog, or pharmaceutically acceptable salt thereof, dissolved, dispersed or suspended in(b) 85% to 90% (wt.) of a biocompatible, biodegradable excipient mixture of: (i) 70% to 80% (wt.) of at least one of d, l and dl isomers of α, β, δ, ε, η tocopherols and isomers of the tocotrienols, the esters of these tocopherols and tocotrienols with straight and branched chain C2 to C20 aliphatic acids and their esters of C3 to C20 straight chain dicarboxylic acids, and(ii) 20% to 30% (wt.) of tri- straight- or branched-chain aliphatic C1 to C10 alcohol esters of citrate or omega-3 fatty acid esters with C1 to C10 straight or branched chain aliphatic alcohols, or about 2.5% (wt.) of d-alpha tocopheryl polyethylene glycol 1000 succinate;wherein said excipient mixture ensures sustained release of a therapeutic amount of said anti-inflammatory agent from said unit dose to the eye for at least four days; andwherein said unit dose is a single eye drop. 2. A dosage dispensing container comprising the unit dose of claim 1 and configured to dispense the single unit dose therefrom. 3. The unit dose of claim 1, wherein the volume of said unit dose is about 25 μL or about 50 μL. 4. The unit dose of claim 1, wherein the anti-inflammatory agent of said pharmaceutical eye drop formulation is dexamethasone and the tocopherol is α-tocopheryl acetate. 5. The unit dose of claim 4, wherein the volume of said unit dose is about 25 μL or about 50 μL.

이 특허에 인용된 특허 (73) 인용/피인용 타임라인 분석

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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Sustained release eye drop formulations 원문보기